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Quality of Life in Rectal Cancer Patients

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Book cover Modern Management of Cancer of the Rectum

Abstract

As more and more patients are surviving rectal cancer, owing to advances in treatment, survivorship issues are now at the forefront of clinical practice and research. The patient’s well-being or quality of life (QoL) is inevitably affected by rectal cancer and its treatment, usually in a variety of ways. The exact impact depends on the aspect of life concerned, tumor characteristics, the treatment involved, the measurement method and timing, as well as the patient. This chapter presents a collection of current knowledge regarding QoL in rectal cancer patients, including the conceptual definition of QoL, QoL measurement and interpretation, QoL following standard and complex rectal cancer surgery, QoL after neoadjuvant therapy, and QoL with or without a permanent colostomy. Better understanding of QoL in rectal cancer not only facilitates enhanced patient information, communication and shared decision-making throughout the patient journey, but also underpins initiatives towards preventing and managing adverse effects to ensure that both the length and quality of the patient’s life are optimized.

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References

  1. Farquhar M. Definitions of quality of life: a taxonomy. J Adv Nurs. 1995;22(3):502–8.

    Article  CAS  PubMed  Google Scholar 

  2. Guyatt GH, Feeny DH, Patrick DL. Measuring health-related quality of life. Ann Intern Med. 1993;118(8):622–9.

    Article  CAS  PubMed  Google Scholar 

  3. Jaeschke R, Singer J, Guyatt GH. Measurement of health status: ascertaining the minimal clinically important difference. Control Clin Trials. 1989;10(4):407–15.

    Article  CAS  PubMed  Google Scholar 

  4. Meyer K, Clayton K. Measurement and analysis of patient-reported outcomes. In: Barrett B, Parfrey P, editors. Clinical epidemiology. New York: Humana Press; 2009. p. 155–69.

    Google Scholar 

  5. The United States Centers for Disease Control and Prevention. Health-Related Quality of Life (HRQOL). The United States Centers for Disease Control and Prevention; [cited 4 Apr 2014]; Available from: http://www.cdc.gov/hrqol/concept.htm.

  6. Cella DF. Quality of life: concepts and definition. J Pain Symptom Manage. 1994;9(3):186–92.

    Article  CAS  PubMed  Google Scholar 

  7. Bakas T, McLennon SM, Carpenter JS, Buelow JM, Otte JL, Hanna KM, et al. Systematic review of health-related quality of life models. Health Qual Life Outcomes. 2012;10:134.

    Article  PubMed Central  PubMed  Google Scholar 

  8. Wilson IB, Cleary PD. Linking clinical variables with health-related quality of life. A conceptual model of patient outcomes. JAMA. 1995;273(1):59–65.

    Article  CAS  PubMed  Google Scholar 

  9. Ferrans CE, Zerwic JJ, Wilbur JE, Larson JL. Conceptual model of health-related quality of life. J Nurs Scholarsh. 2005;37(4):336–42.

    Article  PubMed  Google Scholar 

  10. Ware Jr JE. The status of health assessment 1994. Annu Rev Public Health. 1995;16:327–54.

    Article  PubMed  Google Scholar 

  11. Emmertsen KJ, Laurberg S. Low anterior resection syndrome score: development and validation of a symptom-based scoring system for bowel dysfunction after low anterior resection for rectal cancer. Ann Surg. 2012;255(5):922–8.

    Article  PubMed  Google Scholar 

  12. Hays RD, Morales LS. The RAND-36 measure of health-related quality of life. Ann Med. 2001;33(5):350–7.

    Article  CAS  PubMed  Google Scholar 

  13. Ware Jr JE, Sherbourne CD. The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection. Med Care. 1992;30(6):473–83.

    Article  PubMed  Google Scholar 

  14. McHorney CA, Ware Jr JE, Lu JF, Sherbourne CD. The MOS 36-item Short-Form Health Survey (SF-36): III. Tests of data quality, scaling assumptions, and reliability across diverse patient groups. Med Care. 1994;32(1):40–66.

    Article  CAS  PubMed  Google Scholar 

  15. McHorney CA, Ware Jr JE, Raczek AE. The MOS 36-Item Short-Form Health Survey (SF-36): II. Psychometric and clinical tests of validity in measuring physical and mental health constructs. Med Care. 1993;31(3):247–63.

    Article  CAS  PubMed  Google Scholar 

  16. Jenkinson C, Layte R, Jenkinson D, Lawrence K, Petersen S, Paice C, et al. A shorter form health survey: can the SF-12 replicate results from the SF-36 in longitudinal studies? J Public Health. 1997;19(2):179–86.

    Article  CAS  Google Scholar 

  17. Gandek B, Ware JE, Aaronson NK, Apolone G, Bjorner JB, Brazier JE, et al. Cross-validation of item selection and scoring for the SF-12 Health Survey in nine countries: results from the IQOLA Project. J Clin Epidemiol. 1998;51(11):1171–8.

    Article  CAS  PubMed  Google Scholar 

  18. Hurst NP, Kind P, Ruta D, Hunter M, Stubbings A. Measuring health-related quality of life in rheumatoid arthritis: validity, responsiveness and reliability of EuroQol (EQ-5D). Rheumatology. 1997;36(5):551–9.

    Article  CAS  Google Scholar 

  19. Herdman M, Gudex C, Lloyd A, Janssen MF, Kind P, Parkin D, et al. Development and preliminary testing of the new five-level version of EQ-5D (EQ-5D-5 L). Qual Life Res. 2011;20(10):1727–36.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  20. Pickard AS, De Leon MC, Kohlmann T, Cella D, Rosenbloom S. Psychometric comparison of the standard EQ-5D to a 5 level version in cancer patients. Med Care. 2007;45(3):259–63. doi:10.1097/01.mlr.0000254515.63841.81.

    Article  PubMed  Google Scholar 

  21. Aaronson NK, Ahmedzai S, Bergman B, Bullinger M, Cull A, Duez NJ, et al. The European Organization for Research and Treatment of Cancer QLQ-C30: a quality-of-life instrument for use in international clinical trials in oncology. J Natl Cancer Inst. 1993;85(5):365–76.

    Article  CAS  PubMed  Google Scholar 

  22. Fayers P, Bottomley A. Quality of life research within the EORTC—the EORTC QLQ-C30. Eur J Cancer. 2002;38(Supplement 4):125–33.

    Article  Google Scholar 

  23. Sprangers MA, te Velde A, Aaronson NK. The construction and testing of the EORTC colorectal cancer-specific quality of life questionnaire module (QLQ-CR38). European Organization for Research and Treatment of Cancer Study Group on Quality of Life. Eur J Cancer. 1999;35(2):238–47.

    Article  CAS  PubMed  Google Scholar 

  24. Whistance RN, Conroy T, Chie W, Costantini A, Sezer O, Koller M, et al. Clinical and psychometric validation of the EORTC QLQ-CR29 questionnaire module to assess health-related quality of life in patients with colorectal cancer. Eur J Cancer. 2009;45(17):3017–26.

    Article  CAS  PubMed  Google Scholar 

  25. Cella DF, Tulsky DS, Gray G, Sarafian B, Linn E, Bonomi A, et al. The Functional Assessment of Cancer Therapy scale: development and validation of the general measure. J Clin Oncol. 1993;11(3):570–9.

    CAS  PubMed  Google Scholar 

  26. Webster K, Cella D, Yost K. The Functional Assessment of Chronic Illness Therapy (FACIT) Measurement System: properties, applications, and interpretation. Health Qual Life Outcomes. 2003;1(1):79.

    Article  PubMed Central  PubMed  Google Scholar 

  27. Ward WL, Hahn EA, Mo F, Hernandez L, Tulsky DS, Cella D. Reliability and validity of the Functional Assessment of Cancer Therapy-Colorectal (FACT-C) quality of life instrument. Qual Life Res. 1999;8(3):181–95.

    Article  CAS  PubMed  Google Scholar 

  28. Yoo HJ, Kim JC, Eremenco S, Han OS. Quality of life in colorectal cancer patients with colectomy and the validation of the Functional Assessment of Cancer Therapy-Colorectal (FACT-C), Version 4. J Pain Symptom Manage. 2005;30(1):24–32.

    Article  PubMed  Google Scholar 

  29. de Haes JC, van Knippenberg FC, Neijt JP. Measuring psychological and physical distress in cancer patients: structure and application of the Rotterdam Symptom Checklist. Br J Cancer. 1990;62(6):1034–8.

    Article  PubMed Central  PubMed  Google Scholar 

  30. Sprangers MA, Schwartz CE. The challenge of response shift for quality-of-life-based clinical oncology research. Ann Oncol. 1999;10(7):747–9.

    Article  CAS  PubMed  Google Scholar 

  31. Neuman HB, Park J, Fuzesi S, Temple LK. Rectal cancer patients’ quality of life with a temporary stoma: shifting perspectives. Dis Colon Rectum. 2012;55(11):1117–24.

    Article  PubMed  Google Scholar 

  32. Fayers P, Machin D. Quality of life. The assessment, analysis and interpretation of patient-reported outcomes. 2nd ed. West Sussex: Wiley; 2007.

    Google Scholar 

  33. Osoba D, Rodrigues G, Myles J, Zee B, Pater J. Interpreting the significance of changes in health-related quality-of-life scores. J Clin Oncol. 1998;16(1):139–44.

    CAS  PubMed  Google Scholar 

  34. Fayers P, Aaronson N, Bjordal K, Groenvold M, Curran D, Bottomly A, et al. The EORTC QLQ-C30 scoring manual. 3rd ed. Brussels: European Organisation for Research and Treatment of Cancer; 2001.

    Google Scholar 

  35. Giesinger J, Kemmler G, Mueller V, Zabernigg A, Mayrbaeurl B, Thaler J, et al. Are gender-associated differences in quality of life in colorectal cancer patients disease-specific? Qual Life Res. 2009;18(5):547–55.

    Article  PubMed  Google Scholar 

  36. Arndt V, Merx H, Stegmaier C, Ziegler H, Brenner H. Quality of life in patients with colorectal cancer 1 year after diagnosis compared with the general population: a population-based study. J Clin Oncol. 2004;22(23):4829–36.

    Article  PubMed  Google Scholar 

  37. Kopp I, Bauhofer A, Koller M. Understanding quality of life in patients with colorectal cancer: comparison of data from a randomised controlled trial, a population based cohort study and the norm reference population. Inflamm Res. 2004;53 Suppl 2:S130–5.

    CAS  PubMed  Google Scholar 

  38. Traa MJ, Orsini RG, Den Oudsten BL, De Vries J, Roukema JA, Bosman SJ, et al. Measuring the health-related quality of life and sexual functioning of patients with rectal cancer: does type of treatment matter? Int J Cancer. 2014;134(4):979–87.

    Article  CAS  PubMed  Google Scholar 

  39. Rauch P, Miny J, Conroy T, Neyton L, Guillemin F. Quality of life among disease-free survivors of rectal cancer. J Clin Oncol. 2004;22(2):354–60.

    Article  PubMed  Google Scholar 

  40. Breukink SO, Donovan KA. Physical and psychological effects of treatment on sexual functioning in colorectal cancer survivors. J Sex Med. 2013;10:74–83.

    Article  CAS  PubMed  Google Scholar 

  41. Vironen JH, Kairaluoma M, Aalto AM, Kellokumpu IH. Impact of functional results on quality of life after rectal cancer surgery. Dis Colon Rectum. 2006;49(5):568–78.

    Article  PubMed  Google Scholar 

  42. Marijnen CA, van de Velde CJ, Putter H, van den Brink M, Maas CP, Martijn H, et al. Impact of short-term preoperative radiotherapy on health-related quality of life and sexual functioning in primary rectal cancer: report of a multicenter randomized trial. J Clin Oncol. 2005;23(9):1847–58.

    Article  PubMed  Google Scholar 

  43. Den Oudsten BL, Traa MJ, Thong MSY, Martijn H, De Hingh IHJT, Bosscha K, et al. Higher prevalence of sexual dysfunction in colon and rectal cancer survivors compared with the normative population: a population-based study. Eur J Cancer. 2012;48(17):3161–70.

    Article  Google Scholar 

  44. Lange MM, den Dulk M, Bossema ER, Maas CP, Peeters KC, Rutten HJ, et al. Risk factors for faecal incontinence after rectal cancer treatment. Br J Surg. 2007;94(10):1278–84.

    Article  CAS  PubMed  Google Scholar 

  45. Lange MM, van de Velde CJ. Urinary and sexual dysfunction after rectal cancer treatment. Nat Rev Urol. 2011;8(1):51–7.

    Article  PubMed  Google Scholar 

  46. Lange MM, Maas CP, Marijnen CAM, Wiggers T, Rutten HJ, Kranenbarg EK, et al. Urinary dysfunction after rectal cancer treatment is mainly caused by surgery. Br J Surg. 2008;95(8):1020–8.

    Article  CAS  PubMed  Google Scholar 

  47. Peeters KC, van de Velde CJ, Leer JW, Martijn H, Junggeburt JM, Kranenbarg EK, et al. Late side effects of short-course preoperative radiotherapy combined with total mesorectal excision for rectal cancer: increased bowel dysfunction in irradiated patients–a Dutch colorectal cancer group study. J Clin Oncol. 2005;23(25):6199–206.

    Article  CAS  PubMed  Google Scholar 

  48. Schmidt CE, Bestmann B, Kuchler T, Longo WE, Kremer B. Impact of age on quality of life in patients with rectal cancer. World J Surg. 2005;29(2):190–7.

    Article  PubMed  Google Scholar 

  49. Schmidt CE, Bestmann B, Kuchler T, Longo WE, Rohde V, Kremer B. Gender differences in quality of life of patients with rectal cancer. A five-year prospective study. World J Surg. 2005;29(12):1630–41.

    Article  PubMed  Google Scholar 

  50. Emmertsen KJ, Laurberg S. Bowel dysfunction after treatment for rectal cancer. Acta Oncol. 2008;47(6):994–1003.

    Article  PubMed  Google Scholar 

  51. Bryant CL, Lunniss PJ, Knowles CH, Thaha MA, Chan CL. Anterior resection syndrome. Lancet Oncol. 2012;13(9):e403–8.

    Article  PubMed  Google Scholar 

  52. Pucciani F. A review on functional results of sphincter-saving surgery for rectal cancer: the anterior resection syndrome. Updates Surg. 2013;65(4):257–63.

    Article  PubMed  Google Scholar 

  53. Denost Q, Laurent C, Capdepont M, Zerbib F, Rullier E. Risk factors for fecal incontinence after intersphincteric resection for rectal cancer. Dis Colon Rectum. 2011;54(8):963–8.

    Article  PubMed  Google Scholar 

  54. Emmertsen KJ, Laurberg S. Impact of bowel dysfunction on quality of life after sphincter-preserving resection for rectal cancer. Br J Surg. 2013;100(10):1377–87.

    Article  CAS  PubMed  Google Scholar 

  55. Varpe P, Huhtinen H, Rantala A, Salminen P, Rautava P, Hurme S, et al. Quality of life after surgery for rectal cancer with special reference to pelvic floor dysfunction. Colorectal Dis. 2011;13(4):399–405.

    Article  CAS  PubMed  Google Scholar 

  56. Pollack J, Holm T, Cedermark B, Holmstrom B, Mellgren A. Long-term effect of preoperative radiation therapy on anorectal function. Dis Colon Rectum. 2006;49(3):345–52.

    Article  PubMed  Google Scholar 

  57. Pucciarelli S, Del Bianco P, Efficace F, Toppan P, Serpentini S, Friso ML, et al. Health-related quality of life, faecal continence and bowel function in rectal cancer patients after chemoradiotherapy followed by radical surgery. Support Care Cancer. 2010;18(5):601–8.

    Article  PubMed  Google Scholar 

  58. Juul T, Ahlberg M, Biondo S, Espin E, Jimenez LM, Matzel K, et al. Low anterior resection syndrome and quality of life: an international multicenter study. Dis Colon Rectum. 2014;57:585–91.

    Article  PubMed  Google Scholar 

  59. Chen TY, Wiltink LM, Nout RA, Meershoek-Klein Kranenbarg E, Laurberg S, Marijnen CA, et al. Bowel function 14 years after preoperative short-course radiotherapy and total mesorectal excision for rectal cancer: report of a multicentre randomised trial. Clin Colorectal Cancer. Submitted October 2014.

    Google Scholar 

  60. Juul T, Ahlberg M, Biondo S, Emmertsen KJ, Espin E, Jimenez LM, et al. International validation of the low anterior resection syndrome score. Ann Surg. 2014;259:728–34.

    Article  PubMed  Google Scholar 

  61. Temple LK, Bacik J, Savatta SG, Gottesman L, Paty PB, Weiser MR, et al. The development of a validated instrument to evaluate bowel function after sphincter-preserving surgery for rectal cancer. Dis Colon Rectum. 2005;48(7):1353–65.

    Article  PubMed  Google Scholar 

  62. North J. Early intervention, parastomal hernia and quality of life: a research study. Br J Nurs. 2014;23(5):S14–8.

    Article  PubMed  Google Scholar 

  63. Hotouras A, Murphy J, Thaha M, Chan CL. The persistent challenge of parastomal herniation: a review of the literature and future developments. Colorectal Dis. 2013;15(5):e202–14.

    Article  CAS  PubMed  Google Scholar 

  64. Andersson J, Angenete E, Gellerstedt M, Angeras U, Jess P, Rosenberg J, et al. Health-related quality of life after laparoscopic and open surgery for rectal cancer in a randomized trial. Br J Surg. 2013;100(7):941–9.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  65. Thaysen H, Jess P, Laurberg S, Groenvold M. Validation of the Danish version of the disease specific instrument EORTC QLQ-CR38 to assess health-related quality of life in patients with colorectal cancer. Health Qual Life Outcomes. 2012;10(1):150.

    Article  PubMed Central  PubMed  Google Scholar 

  66. Krouse RS, Herrinton LJ, Grant M, Wendel CS, Green SB, Mohler MJ, et al. Health-related quality of life among long-term rectal cancer survivors with an ostomy: manifestations by sex. J Clin Oncol. 2009;27(28):4664–70.

    Article  PubMed Central  PubMed  Google Scholar 

  67. Loos M, Quentmeier P, Schuster T, Nitsche U, Gertler R, Keerl A, et al. Effect of preoperative radio(chemo)therapy on long-term functional outcome in rectal cancer patients: a systematic review and meta-analysis. Ann Surg Oncol. 2013;20(6):1816–28.

    Article  PubMed  Google Scholar 

  68. Lange MM, Marijnen CAM, Maas CP, Putter H, Rutten HJ, Stiggelbout AM, et al. Risk factors for sexual dysfunction after rectal cancer treatment. Eur J Cancer. 2009;45(9):1578–88.

    Article  CAS  PubMed  Google Scholar 

  69. Ho VP, Lee Y, Stein SL, Temple LK. Sexual function after treatment for rectal cancer: a review. Dis Colon Rectum. 2011;54(1):113–25.

    Article  PubMed  Google Scholar 

  70. Hendren SK, O’Connor BI, Liu M, Asano T, Cohen Z, Swallow CJ, et al. Prevalence of male and female sexual dysfunction is high following surgery for rectal cancer. Ann Surg. 2005;242(2):212–23.

    Article  PubMed Central  PubMed  Google Scholar 

  71. Schmidt C, Daun A, Malchow B, Kuchler T. Sexual impairment and its effects on quality of life in patients with rectal cancer. Dtsch Arztebl Int. 2010;107(8):123–30.

    PubMed Central  PubMed  Google Scholar 

  72. Mols F, Lemmens V, Bosscha K, van den Broek W, Thong MSY. Living with the physical and mental consequences of an ostomy: a study among 1–10-year rectal cancer survivors from the population-based PROFILES registry. Psychooncology. 2014;23:998–1004.

    Article  PubMed  Google Scholar 

  73. Pachler J, Wille-Jorgensen P. Quality of life after rectal resection for cancer, with or without permanent colostomy. Cochrane Database Syst Rev. 2012;12:CD004323.

    Google Scholar 

  74. Cornish JA, Tilney HS, Heriot AG, Lavery IC, Fazio VW, Tekkis PP. A meta-analysis of quality of life for abdominoperineal excision of rectum versus anterior resection for rectal cancer. Ann Surg Oncol. 2007;14(7):2056–68.

    Article  PubMed  Google Scholar 

  75. Jorgensen ML, Young JM, Dobbins TA, Solomon MJ. Assessment of abdominoperineal resection rate as a surrogate marker of hospital quality in rectal cancer surgery. Br J Surg. 2013;100(12):1655–63.

    CAS  PubMed  Google Scholar 

  76. Li J, Chen R, Xu Y-Q, Wang X-C, Zheng S, Zhang S-Z, et al. Impact of a laparoscopic resection on the quality of life in rectal cancer patients: results of 135 patients. Surg Today. 2010;40(10):917–22.

    Article  PubMed  Google Scholar 

  77. Kang S-B, Park JW, Jeong S-Y, Nam BH, Choi HS, Kim D-W, et al. Open versus laparoscopic surgery for mid or low rectal cancer after neoadjuvant chemoradiotherapy (COREAN trial): short-term outcomes of an open-label randomised controlled trial. Lancet Oncol. 2010;11(7):637–45.

    Article  PubMed  Google Scholar 

  78. Braga M, Frasson M, Vignali A, Zuliani W, Capretti G, Di Carlo V. Laparoscopic resection in rectal cancer patients: outcome and cost-benefit analysis. Dis Colon Rectum. 2007;50(4):464–71.

    Article  PubMed  Google Scholar 

  79. Ng SS, Leung WW, Wong CY, Hon SS, Mak TW, Ngo DK, et al. Quality of life after laparoscopic vs open sphincter-preserving resection for rectal cancer. World J Gastroenterol. 2013;19(29):4764–73.

    Article  PubMed Central  PubMed  Google Scholar 

  80. Ohtani H, Tamamori Y, Azuma T, Mori Y, Nishiguchi Y, Maeda K, et al. A meta-analysis of the short- and long-term results of randomized controlled trials that compared laparoscopy-assisted and conventional open surgery for rectal cancer. J Gastrointest Surg. 2011;15(8):1375–85.

    Article  PubMed  Google Scholar 

  81. McGlone ER, Khan OA, Conti J, Iqbal Z, Parvaiz A. Functional outcomes following laparoscopic and open rectal resection for cancer. Int J Surg. 2012;10(6):305–9.

    Article  PubMed  Google Scholar 

  82. Kim J, Kim N-K, Lee K, Hur H, Min B, Kim J. A comparative study of voiding and sexual function after total mesorectal excision with autonomic nerve preservation for rectal cancer: laparoscopic versus robotic surgery. Ann Surg Oncol. 2012;19(8):2485–93.

    Article  PubMed  Google Scholar 

  83. Luca F, Valvo M, Ghezzi TL, Zuccaro M, Cenciarelli S, Trovato C, et al. Impact of robotic surgery on sexual and urinary functions after fully robotic nerve-sparing total mesorectal excision for rectal cancer. Ann Surg. 2013;257(4):672–8.

    Article  PubMed  Google Scholar 

  84. D’Annibale A, Pernazza G, Monsellato I, Pende V, Lucandri G, Mazzocchi P, et al. Total mesorectal excision: a comparison of oncological and functional outcomes between robotic and laparoscopic surgery for rectal cancer. Surg Endosc. 2013;27(6):1887–95.

    Article  PubMed  Google Scholar 

  85. Collinson F, Jayne D, Pigazzi A, Tsang C, Barrie J, Edlin R, et al. An international, multicentre, prospective, randomised, controlled, unblinded, parallel-group trial of robotic-assisted versus standard laparoscopic surgery for the curative treatment of rectal cancer. Int J Colorectal Dis. 2012;27(2):233–41.

    Article  PubMed  Google Scholar 

  86. De Caluwe L, Van Nieuwenhove Y, Ceelen WP. Preoperative chemoradiation versus radiation alone for stage II and III resectable rectal cancer. Cochrane Database Syst Rev. 2013;2:CD006041.

    Google Scholar 

  87. Thaysen HV. Health-related quality of life after complex rectal surgery for primary advanced rectal cancer and locally recurrent rectal cancer [PhD thesis]. Aarhus: Aarhus University; 2013.

    Google Scholar 

  88. Thaysen HV, Jess P, Laurberg S. Health-related quality of life after surgery for primary advanced rectal cancer and recurrent rectal cancer: a review. Colorectal Dis. 2012;14(7):797–803.

    Article  CAS  PubMed  Google Scholar 

  89. Thaysen HV, Jess P, Rasmussen PC, Nielsen MB, Laurberg S. Health-related quality of life after surgery for advanced and recurrent rectal cancer: a nationwide prospective study. Colorectal Dis. 2014;16:O223–33.

    Article  CAS  PubMed  Google Scholar 

  90. Zoucas E, Frederiksen S, Lydrup M-L, Månsson W, Gustafson P, Alberius P. Pelvic exenteration for advanced and recurrent malignancy. World J Surg. 2010;34(9):2177–84.

    Article  PubMed  Google Scholar 

  91. Austin KK, Young JM, Solomon MJ. Quality of life of survivors after pelvic exenteration for rectal cancer. Dis Colon Rectum. 2010;53(8):1121–6.

    Article  PubMed  Google Scholar 

  92. Palmer G, Martling A, Lagergren P, Cedermark B, Holm T. Quality of life after potentially curative treatment for locally advanced rectal cancer. Ann Surg Oncol. 2008;15(11):3109–17.

    Article  PubMed  Google Scholar 

  93. Wright FC, Crooks D, Fitch M, Hollenberg E, Maier BA, Last LD, et al. Qualitative assessment of patient experiences related to extended pelvic resection for rectal cancer. J Surg Oncol. 2006;93(2):92–9.

    Article  CAS  PubMed  Google Scholar 

  94. Love US, Sjogren P, Rasmussen P, Laurberg S, Christensen HK. Sexual dysfunction after colpectomy and vaginal reconstruction with a vertical rectus abdominis myocutaneous flap. Dis Colon Rectum. 2013;56(2):186–90.

    Article  PubMed  Google Scholar 

  95. The Beyond TME Collaborative. Consensus statement on the multidisciplinary management of patients with recurrent and primary rectal cancer beyond total mesorectal excision planes. Br J Surg. 2013;100(8):1009–14.

    Article  Google Scholar 

  96. Earlam S, Glover C, Fordy C, Burke D, Allen-Mersh TG. Relation between tumor size, quality of life, and survival in patients with colorectal liver metastases. J Clin Oncol. 1996;14(1):171–5.

    CAS  PubMed  Google Scholar 

  97. Maisey NR, Norman A, Watson M, Allen MJ, Hill ME, Cunningham D. Baseline quality of life predicts survival in patients with advanced colorectal cancer. Eur J Cancer. 2002;38(10):1351–7.

    Article  CAS  PubMed  Google Scholar 

  98. Sanchez R, Alexander-Sierra F, Oliveros R. Relationship between quality of life and clinical status in patients with gastrointestinal cancer. Rev Esp Enferm Dig. 2012;104(11):584–91.

    Article  PubMed  Google Scholar 

  99. Sloan JA, Zhao X, Novotny PJ, Wampfler J, Garces Y, Clark MM, et al. Relationship between deficits in overall quality of life and non–small-cell lung cancer survival. J Clin Oncol. 2012;30(13):1498–504.

    Article  PubMed Central  PubMed  Google Scholar 

  100. Cella D, Kallich J, McDermott A, Xu X. The longitudinal relationship of hemoglobin, fatigue and quality of life in anemic cancer patients: results from five randomized clinical trials. Ann Oncol. 2004;15(6):979–86.

    Article  CAS  PubMed  Google Scholar 

  101. Crawford J, Cella D, Cleeland CS, Cremieux P-Y, Demetri GD, Sarokhan BJ, et al. Relationship between changes in hemoglobin level and quality of life during chemotherapy in anemic cancer patients receiving epoetin alfa therapy. Cancer. 2002;95(4):888–95.

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Surgery, Section for Colorectal and Mamma-Endocrine Surgery, Aarhus University Hospital, Aarhus, 8000, Denmark

    Therese Juul RN, MHSc, PhD, Henriette Vind Thaysen RN, MHSc, PhD & Tina Yen-Ting Chen MBChB, PhD

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  1. Therese Juul RN, MHSc, PhD
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  2. Henriette Vind Thaysen RN, MHSc, PhD
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  3. Tina Yen-Ting Chen MBChB, PhD
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Correspondence to Therese Juul RN, MHSc, PhD .

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Editors and Affiliations

  1. Colon and Rectal Surgery, Yale School of Medicine, New Haven, Connecticut, USA

    Walter E. Longo

  2. Colon and Rectal Surgery, Yale School of Medicine, New Haven, Connecticut, USA

    Vikram Reddy

  3. University of Liverpool St Helens Teaching Hospital, St Helens, United Kingdom

    Riccardo A. Audisio

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Juul, T., Thaysen, H.V., Chen, T.YT. (2015). Quality of Life in Rectal Cancer Patients. In: Longo, W., Reddy, V., Audisio, R. (eds) Modern Management of Cancer of the Rectum. Springer, London. https://doi.org/10.1007/978-1-4471-6609-2_23

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  • DOI: https://doi.org/10.1007/978-1-4471-6609-2_23

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