Abstract
Constitutive relations for describing the biomechanical behavior of arteries have continued to progress since the late 1960s and we now have considerable ability to understand and predict many mechanical and mechanobiological processes. Nevertheless, advances in both genetics and cell and matrix biology have revealed new needs with regard to describing the biomechanics. In this chapter, we briefly review arterial structure and prior biomechanical constitutive approaches and then discuss a growing appreciation of the details of the arterial extracellular matrix and the need to include such detail in future constitutive relations. As it will be seen, much has been learned, yet much remains to be accomplished in the formulation of constitutive relations for arteries that can provide true predictive capability with regard to mechanobiological aspects of the development, maintenance, adaptation, disease progression, and responses to injury.
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Acknowledgments
This work was supported, in part, by grants to JDH from the NIH (HL086418, HL105297) and National Marfan Foundation as well as by a predoctoral fellowship to JSW from the American Heart Association-Founders Affiliate.
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Humphrey, J.D., Wilson, J.S. (2015). Arteries: Mechanics, Mechanobiology, and the Need for a New Class of Models. In: De, S., Hwang, W., Kuhl, E. (eds) Multiscale Modeling in Biomechanics and Mechanobiology. Springer, London. https://doi.org/10.1007/978-1-4471-6599-6_9
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DOI: https://doi.org/10.1007/978-1-4471-6599-6_9
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