Abstract

Osteomyelitis is the inflammation of bone and bone marrow, usually secondary to an infectious agent. It can be hematogenous or following a trauma. Children have a higher incidence of infection in the metaphysis of long bones and adults in axial skeletal. Staphylococcus aureus is the more frequent culprit. In intravenous drug users, Pseudomonas is common. Salmonella has a predilection for patients with sickle cell disease. Irregular areas of radiolucency are later associated with the formation of a sinus tract and osteosclerosis. Findings in a small biopsy will vary significantly with the area biopsied and disease time: acute inflammation, necrosis, or chronic active inflammation. Systemic antibiotic is the treatment of choice. For all cases, the cure rate is considered above 90 %.

Keywords

Osteomyelitis Infection Bone Bacteriological culture 

Recommended Reading

  1. Abdelwahab IF, Present DA, Zwass A, et al. Tumorlike tuberculous granulomas of bone. Am J Roentgenol. 1987;149(6):1207–8.CrossRefGoogle Scholar
  2. Abdelwahab IF, Norman A, Hermann G, et al. Atypical radiographic appearances of tuberculous granulomas of bone. Can Assoc Radiol J. 1990;41(2):72–5.PubMedGoogle Scholar
  3. Chandrasekar PH, Narula AP. Bone and joint infections in intravenous drug abusers. Rev Infect Dis. 1986;8(6):904–11.CrossRefPubMedGoogle Scholar
  4. Collert S, Isacson J. Chronic sclerosing osteomyelitis (Garré). Clin Orthop Relat Res. 1982;164:136–40.PubMedGoogle Scholar
  5. Gifford DB, Patzakis M, Ivler D, Swezey RL. Septic arthritis due to Pseudomonas in heroin addicts. J Bone Joint Surg. 1975;57:631–5.PubMedGoogle Scholar
  6. Ogden JA, Lister G. The pathology of neonatal osteomyelitis. Pediatrics. 1975;55:474–8.PubMedGoogle Scholar
  7. Sato R, Matsui Y, Yokoi H, et al. Chronic osteomyelitis of the tibia resembling benign bone tumors. Pediatr Int. 2007;49(5):663–7.CrossRefPubMedGoogle Scholar
  8. Trueta J. The three types of acute hematogenous osteomyelitis. J Bone Joint Surg Am. 1959;41(B):671.Google Scholar
  9. Vinh T. Infections and inflammatory diseases. In: Non-neoplastic diseases of bones and joints (Atlas of non-tumor pathology, Fascicle 9). Silver Spring: ARP Press; 2011.Google Scholar

Copyright information

© Springer-Verlag London 2015

Authors and Affiliations

  1. 1.Department of Pathology and Laboratory MedicineHospital for Special SurgeryNew YorkUSA

Personalised recommendations