“Brown Tumor” of Hyperparathyroidism
Localized destructive cyst-like areas in the skeleton, due to osteoclast resorption, in the general frame of primary, secondary, or tertiary hyperparathyroidism. It is more frequent in females and has the highest incidence between third and sixth decades. It is most common in tubular bones of the extremities and maxillary bones. The lesions may involve any skeletal bone and may be solitary or multiple. Radiologically, lesions are osteolytic with undefined margins. Histologically the bone marrow is replaced by a loose, richly vascularized, connective tissue. The remaining cancellous bone shows an increased osteoclastic activity on its surface. Hemorrhage and abundant hemosiderin pigment deposits are present. The most common differential diagnosis is a giant cell tumor of the bone. Surgical treatment in case of hyperfunctioning parathyroid – adenoma or hyperplastic glands – tends to reduce the osteoclastic activity.
KeywordsHyperparathyroidism Giant cells Brown tumor Multiple
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