Abstract
Myeloma is a malignant tumor of plasma cell lineage; these cells proliferate and infiltrate the bone marrow, displacing the normal marrow and initiating secondary changes in the surrounding bone. Myeloma may be solitary at the outset (plasmacytoma or solitary myeloma) or it may present systemically (multiple myeloma, myelomatosis). There is a male predominance seen in most clinical series. Myeloma is a disease of older adults; most patients are in the sixth and seventh decades of life. Myeloma is most frequently in the distribution of red marrow. The axial skeleton is most frequently involved. Radiologically, myeloma may present as a solitary radiolucent lesion or multiple punched-out lesions without reactive or sclerotic borders. Histologically, punched-out or space-occupying lesions are comprised of cells having terminal plasma cell differentiation. Treatment options for multiple myeloma range from alkylating agents in combination with steroids to highly tailored combination drug regimens with or without marrow transplantation.
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Cavo M, Rajkumar SV, Palumbo A, Moreau P, et al. International Myeloma Working Group consensus approach to the treatment of multiple myeloma patients who are candidates for autologous stem cell transplantation. Blood. 2011;117(23):6063–73.
Dimpoulos MA, Moulopoulos LA, Maniatis A, et al. Solitary plasmacytoma of bone and asymptomatic multiple myeloma. Blood. 2004;96:2037–44.
Dispenzieri A. POEMS syndrome: update on diagnosis, risk-stratification, and management. Am J Hematol. 2011;86:591–601.
Durie BGM. The epidemiology of multiple myeloma. Semin Hematol. 2001;38:1–5.
Durie BGM, Salmon SE. Myeloma management guidelines: a consensus report from the Scientific Advisors of the International Myeloma Foundation. Int J Hematol. 2003;4:379–98.
Fonseca R, Monge J. Myeloma: classification and risk assessment. Semin Oncol. 2013;40(5):554–66.
Fonseca R, Monge J, Dimopoulos MA. Staging and prognostication of multiple myeloma. Expert Rev Hematol. 2014;7(1):21–31.
Jasielec JK, Jakubowiak AJ. Current approaches to the initial treatment of symptomatic multiple myeloma. Int J Hematol Oncol. 2013; Feb;2(1). doi:10.2217/ijh.13.3.
Kaya H, Peressini B, Jawed I, et al. Impact of age, race and decade of treatment on overall survival in a critical population of 40,000 multiple myeloma patients. Int J Hematol. 2012;95:64–70.
Kumar SK, Dispenzieri A, Lacy MQ, et al. Continued improvement in survival in multiple myeloma: changes in early mortality and outcomes in older patients. Leukemia. 2014;28(5):1122–8. doi:10.1038/leu.2013.313.
Kyle RA, Gertz MA, Witzig TE, et al. Review of 1027 patients with newly diagnosed multiple myeloma. Mayo Clin Proc. 2003;78:21–33.
Lorsbach R, Kluin PM. Plasma cell myeloma. In: Fletcher CDM, Bridge JA, Hogendoorn PCW, Mertens F, editors. WHO classification of tumors of soft tissue and bone. Lyon: International Agency for Research on Cancer; 2013a. p. 312–4.
Lorsbach R, Kluin PM. Solitary plasmacytoma of bone. In: Fletcher CDM, Bridge JA, Hogendoorn PCW, Mertens F, editors. WHO classification of tumors of soft tissue and bone. Lyon: International Agency for Research on Cancer; 2013b. p. 315.
McCarthy PL, Einsele H, Attal M, Giralt S. The emerging role of consolidation and maintenance therapy for transplant-eligible multiple myeloma patients. Expert Rev Hematol. 2014;7(1):55–66.
McKenna RW, Kyle RA, Kuehl WM. Plasma cell neoplasms. In: Swerdlow SH, Campo E, Harris NL, editors. WHO classification of tumours of haematopoietic and lymphoid tissue. Lyon: International Agency for Research on Cancer; 2008. p. 200–13.
Soutar R, Lucraft H, Jackson G, et al. Guidelines on the diagnosis and management of solitary plasmacytoma of bone and solitary extramedullary plasmacytoma. Br J Haematol. 2004;124:717–26.
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Klein, M.J. (2015). Myeloma. In: Santini-Araujo, E., Kalil, R., Bertoni, F., Park, YK. (eds) Tumors and Tumor-Like Lesions of Bone. Springer, London. https://doi.org/10.1007/978-1-4471-6578-1_27
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DOI: https://doi.org/10.1007/978-1-4471-6578-1_27
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