Skip to main content
SpringerLink
Log in

Chronic Burn Ulceration of the Skin and the Potential of Amniotic Membrane-Based Therapy

  • Chapter
  • First Online:
Regenerative Medicine

  • 1174 Accesses

Abstract

In a recent report, it has been brought to notice that close to five million people in the USA are affected by chronic wounds and billions are spent annually for their treatment. Despite advances in chronic wound management over the past decades, many patients afflicted with chronic wounds fail to heal or their ulcers recur. Why is this so?

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.00
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Siepe M, Thomsen AR, Duerkopp N, Krause U, Förster K, Hezel P, Beyersdorf F, Schlensak C, Südkamp NP, Bosse R, Niemeyer P. Human neonatal thymus-derived mesenchymal stromal cells: characterization, differentiation, and immunomodulatory properties. Tissue Eng Part A. 2009;15(7):1787–96. doi:10.1089/ten.

    Article  CAS  PubMed  Google Scholar 

  2. Nikoo S, Ebtekar M, Jeddi-Tehrani M, Shervin A, Bozorgmehr M, Kazemnejad S, Zarnani AH. Effect of menstrual blood-derived stromal stem cells on proliferative capacity of peripheral blood mononuclear cells in allogeneic mixed lymphocyte reaction. J Obstet Gynaecol Res. 2012;38(5):804–9.

    Article  CAS  PubMed  Google Scholar 

  3. Poloni A, Maurizi G, Rosini V, Mondini E, Mancini S, Discepoli G, Biasio S, Battaglini G, Felicetti S, Berardinelli E, Serrani F, Leoni P. Selection of CD271(+) cells and human AB serum allows a large expansion of mesenchymal stromal cells from human bone marrow. Cytotherapy. 2009;11(2):153–62.

    Article  CAS  PubMed  Google Scholar 

  4. Bieback K, Hecker A, Kocaömer A, Lannert H, Schallmoser K, Strunk D, Klüter H. Human alternatives to fetal bovine serum for the expansion of mesenchymal stromal cells from bone marrow. Stem Cells. 2009;27(9):2331–41.

    Article  CAS  PubMed  Google Scholar 

  5. Dabiri G, Heiner D, Falanga V. The emerging use of bone marrow-derived mesenchymal stem cells in the treatment of human chronic wounds. Expert Opin Emerg Drugs. 2013;18(4):405–19.

    Google Scholar 

  6. Huang S, Lu G, Wu Y, Jirigala E, Xu Y, Ma K, Fu X. Mesenchymal stem cells delivered in a microsphere-based engineered skin contribute to cutaneous wound healing and sweat gland repair. J Dermatol Sci. 2012;66(1):29–36.

    Article  CAS  PubMed  Google Scholar 

  7. Wu Y, Chen L, Scott PG, Tredget EE. Mesenchymal stem cells enhance wound healing through differentiation and angiogenesis. Stem Cells. 2007;25(10):2648–59.

    Article  CAS  PubMed  Google Scholar 

  8. Mustoe T. Understanding chronic wounds: a unifying hypothesis on their pathogenesis and implications for therapy. Am J Surg. 2004;187(5):S65. doi:10.1016/S0002-9610(03)00306-4,10.1016%2FS0002-9610%2803%2900306-4. PMID 15147994.

    Article  Google Scholar 

  9. Edwards J, Howley P, Cohen IK. In vitro inhibition of human neutrophil elastase by oleic acid albumin formulations from derivatized cotton wound dressings. Int J Pharm. 2004;284(1–2):1–12.

    Article  CAS  PubMed  Google Scholar 

  10. Martin P. Wound healing—aiming for perfect skin regeneration. Science. 1997;276:75–81.

    Article  CAS  PubMed  Google Scholar 

  11. Boulton AJ, Vileikyte L, Ragnarson-Tennvall G, et al. The global burden of diabetic foot disease. Lancet. 2005;366:1719–24.

    Article  PubMed  Google Scholar 

  12. Pittenger MF, Mackay AM, Beck SC, et al. Multilineage potential of adult human mesenchymal stem cells. Science. 1999;284:143–14.

    Article  CAS  PubMed  Google Scholar 

  13. Sato Y, Araki H, Kato J, et al. Human mesenchymal stem cells xenografted directly to rat liver are differentiated into human hepatocytes without fusion. Blood. 2005;106:756–63.

    Article  CAS  PubMed  Google Scholar 

  14. Toma C, Pittenger MF, Cahill KS, et al. Human mesenchymal stem cells differentiate to a cardiomyocyte phenotype in the adult murine heart. Circulation. 2002;105:93–8.

    Article  PubMed  Google Scholar 

  15. Amado LC, Saliaris AP, Schuleri KH, et al. Cardiac repair with intramyocardial injection of allogeneic mesenchymal stem cells after myocardial infarction. Proc Natl Acad Sci U S A. 2005;102:11474–9.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  16. Kopen GC, Prockop DJ, Phinney DG. Marrow stromal cells migrate throughout forebrain and cerebellum, and they differentiate into astrocytes after injection into neonatal mouse brains. Proc Natl Acad Sci U S A. 1999;96:10711–6.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  17. Kondo T, Johnson SA, Yoder MC, et al. Sonic hedgehog and retinoic acid synergistically promote sensory fate specification from bone marrow-derived pluripotent stem cells. Proc Natl Acad Sci U S A. 2005;102:4789–94.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  18. Phinney DG, Prockop DJ. Concise review: mesenchymal stem/multipotent stromal cells: the state of transdifferentiation and modes of tissue repair–current views. Stem Cells. 2007;25:2896–902.

    Article  PubMed  Google Scholar 

  19. Nauta AJ, Fibbe WE. Immunomodulatory properties of mesenchymal stromal cells. Blood. 2007;110:3499–506.

    Article  CAS  PubMed  Google Scholar 

  20. O’Donoghue K, Choolani M, Chan J, et al. Identification of fetal mesenchymal stem cells in maternal blood: implications for non-invasive prenatal diagnosis. Mol Hum Reprod. 2003;9:497–502.

    Article  PubMed  Google Scholar 

  21. O’Donoghue K, Chan J, de La Fuente J, et al. Microchimerism in female bone marrow and bone decades after fetal mesenchymal stem-cell trafficking in pregnancy. Lancet. 2004;364:179–82.

    Article  PubMed  Google Scholar 

  22. Perin L, Giuliani S, Jin D, et al. Renal differentiation of amniotic fluid stem cells. Cell Prolif. 2007;40(6):936–48.

    Article  CAS  PubMed  Google Scholar 

  23. Wu Y, Chen L, Scott PG, Tredget EE. Mesenchymal stem cells enhance wound healing through differentiation and angiogenesis. Stem Cells. 2007;25(10):2648–59.

    Article  CAS  PubMed  Google Scholar 

  24. Sorrell JM, Caplan AI. Topical delivery of mesenchymal stem cells and their function in wounds. Stem Cell Res Ther. 2010;1:30. doi:10.1186/scrt30.

    Article  PubMed Central  PubMed  Google Scholar 

  25. Baraniak PR, McDevitt TC. Stem cell paracrine actions and tissue regeneration. Regen Med. 2010;5:121–43.

    Article  PubMed Central  PubMed  Google Scholar 

  26. Sensebe L, Krampera M, Schrezenmeier H, Bourin P, Giordano R. Mesenchymal stem cells for clinical application. Vox Sang. 2010;98:93–107. doi:10.1111/j.1423-0410.2009.01227.x).

    Article  CAS  PubMed  Google Scholar 

  27. Wu Y, Chen L, Scott PG, Tredget EE. Mesenchymal stem cells enhance wound healing through differentiation and angiogenesis. Stem Cells. 2007;25:2648–59. doi:10.1634/stemcells.2007-0226.

    Article  CAS  PubMed  Google Scholar 

  28. Sarkar D, Spencer JA, Phillips JA, Zhao W, Schafer S, Spelke DP, Mortensen LJ, Ruiz JP, Vemula PK, Sridharan R, et al. Engineered cell homing. Blood. 2011;118(25):e184–91.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Regenerative Medicine and Transplant science, Calcutta School of Tropical Medicine, 108 Chittaranjan avenue, Kolkata, West Bengal, 700073, India

    Niranjan Bhattacharya MBBS, MD, MS, DSc, FACS (USA) & Akash Bhattacharya MTech

  2. Orthopaedic Surgery, Belle Vue Clinic, U.N. Brahmachari Street, Calcutta, West Bengal, 700075, India

    Shyama Prasad Das D Orth, MS (Ortho), FICS(USA)

  3. Department of Health and Family Welfare, Government of West Bengal, Vidyasagar State General Hospital, Behala, Brahma Samaj Road, Kolkata, West Bengal, 700034, India

    Diptendu Bikash Sengupta MBBS, MS & Soumen K. Bhattacharya MBBS, MD

  4. Department of Regenerative Medicine and Translational Science, Calcutta School of Tropical Medicine, P.L. Deuty Road, Bishnupur 24 pgs, Kolkata, West Bengal, 743503, India

    Prosanto Chowdhury MBBS, MSc & Dhritidipa Chowdhury MBBS, DGO, DNB

  5. Cardiothoracic and Vascular Surgery, Medical College Hospital, College street, Kolkata, West Bengal, 700073, India

    Kalisankar Das MBBS, MS & Niranjan Maity MBBS (CAL)

  6. Gynaecologist (Retired), West Bengal Health Service, Government of West Bengal, Kolkata, West Bengal, India

    Debranjan Basu MBBS, MD & Samir Chaudhuri MBBS, MD

  7. Department of Health and Family Welfare, Government of West Bengal School of Tropical Medicine, 108 C.R. Avenue, Kolkata, 700073, West Bengal, India

    Soma Das MBBS DCH pathology & Biswanath Chakraborty MSc

  8. Department of Health and Family Welfare, Government of West Bengal Medical College, College Street, Kolkata, West Bengal, 700073, India

    Raja Bhattacharya MBBS, MD

  9. Department of Medical Biotechnology, School of Tropical Medicine, Chittaranjan avenue, Kolkata, West Bengal, 700073, India

    Dipanjan Sengupta MSc

  10. WHO (Sydney University) Community Medicine, North Bengal Medical College, Sushrutanagar, Siliguri, West Bengal, 734102, India

    Aditi Aikat MBBS, MD

  11. W.B. Health and Family Welfare Department, Vidyasagar State General Hospital, Behala, Kol-34, Brahma Samaj Road, Kolkata, West Bengal, 70034, India

    Tapan Rakshit MSS, MS & Uttam Majumder MBBS, DCH, FICMCH, FIAMS

  12. Department of Biochemistry and Medical Biotechnology, Calcutta school of Tropical Medicine, C.R. avenue, Koklata, West Bengal, 700073, India

    Biswanath Chakraborty MSc & Sujata Law PhD

  13. Laboratory Medicine, School of Tropical Medicine, 108 C.R. avenue, Kolkata, West Bengal, 700073, India

    Swapna Chaudhuri MSc PhD

  14. Clinical and Experimental Pharmacology, Calcutta School of Tropical Medicine, 108 Chittaranjan avenue, Kolkata, West Bengal, 700073, India

    Santanu K. Tripathi MBBS, MD, DM

  15. West Bengal Medical Education Service (WBMES), School of Tropical Medicine, 108 Chittaranjan Avenue, Kolkata, 700073, West Bengal, India

    Nandita Basu MBBS, MD(PATH), DTM&H

  16. Health of Family Welfare, Swasthya Bhavan, Government of West Bengal, GN-29, Salt Lake, Kolkata, 700 091, India

    Sushanta Kumar Banerjee MD

  17. Animal Biotechnology Centre, National Dairy Research Institute, G.T. Road, Karnal, Haryana, 132001, India

    Dhruba Malakar PhD

  18. Department of Health and Family Welfare, School of Tropical Medicine, Cittaranjan Avenue, Kolkata, West Bengal, India

    Samarendranarayan Choudhuri MBBS, MD

Authors
  1. Niranjan Bhattacharya MBBS, MD, MS, DSc, FACS (USA)
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Shyama Prasad Das D Orth, MS (Ortho), FICS(USA)
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Diptendu Bikash Sengupta MBBS, MS
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Prosanto Chowdhury MBBS, MSc
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Dhritidipa Chowdhury MBBS, DGO, DNB
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Kalisankar Das MBBS, MS
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Soma Das MBBS DCH pathology
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Niranjan Maity MBBS (CAL)
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Raja Bhattacharya MBBS, MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Dipanjan Sengupta MSc
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. Aditi Aikat MBBS, MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  12. Debranjan Basu MBBS, MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  13. Samir Chaudhuri MBBS, MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  14. Tapan Rakshit MSS, MS
    View author publications

    You can also search for this author in PubMed Google Scholar

  15. Akash Bhattacharya MTech
    View author publications

    You can also search for this author in PubMed Google Scholar

  16. Soumen K. Bhattacharya MBBS, MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  17. Uttam Majumder MBBS, DCH, FICMCH, FIAMS
    View author publications

    You can also search for this author in PubMed Google Scholar

  18. Biswanath Chakraborty MSc
    View author publications

    You can also search for this author in PubMed Google Scholar

  19. Swapna Chaudhuri MSc PhD
    View author publications

    You can also search for this author in PubMed Google Scholar

  20. Sujata Law PhD
    View author publications

    You can also search for this author in PubMed Google Scholar

  21. Santanu K. Tripathi MBBS, MD, DM
    View author publications

    You can also search for this author in PubMed Google Scholar

  22. Nandita Basu MBBS, MD(PATH), DTM&H
    View author publications

    You can also search for this author in PubMed Google Scholar

  23. Sushanta Kumar Banerjee MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  24. Dhruba Malakar PhD
    View author publications

    You can also search for this author in PubMed Google Scholar

  25. Samarendranarayan Choudhuri MBBS, MD
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Calcutta School of Tropical Medicine, Kolkata, India

    Niranjan Bhattacharya

  2. Boston University School of Medicine, Jamaica Plain, Massachusetts, USA

    Phillip George Stubblefield

Rights and permissions

Reprints and permissions

Copyright information

© 2015 Springer-Verlag London

About this chapter

Cite this chapter

Bhattacharya, N. et al. (2015). Chronic Burn Ulceration of the Skin and the Potential of Amniotic Membrane-Based Therapy. In: Bhattacharya, N., Stubblefield, P. (eds) Regenerative Medicine. Springer, London. https://doi.org/10.1007/978-1-4471-6542-2_29

Download citation

  • DOI: https://doi.org/10.1007/978-1-4471-6542-2_29

  • Published:

  • Publisher Name: Springer, London

  • Print ISBN: 978-1-4471-6541-5

  • Online ISBN: 978-1-4471-6542-2

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation