Leprosy, which was known to ancient India as “Kushta Roga,” is thought to have originated from India. India is now having the maximum numbers of leprosy cases and accounts for 67 % of the total prevalence and 73 % of total new cases detected worldwide. Huge numbers of new cases have been detected in recent years (last year new cases detected were 782,501) because of the adoption of a new strategy, the Modified Leprosy Elimination Campaign (MLEC), and an effective health education campaign. Presently, 70 % of the total new caseloads of India are from five most heavily infected states. There is a significant improvement in the overall situation as is evident from the steady decline of the prevalence rate from 38.6 cases per 10,000 population in 1985 to 5.0 per 10,000 population in 1999.
Amniotic Fluid Mesenchymal Stromal Cell Amniotic Membrane National Rural Health Mission Amniotic Epithelial Cell
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The authors gratefully acknowledge the support of Prof Andrew Burd, HOD Dept of Plastic and Reconstructive Surgery Chinese University of Hong Kong. The Department of Science and Technology, Government of West Bengal, supported the investigator with a research grant during his tenure at Bijoygarh State Hospital from 1999 to 2006. The work started in Bijoygarh Government Hospital (1999–2006) and was followed up at Vidyasagar Government Hospital subsequently. The author gratefully acknowledges the support of the patients who volunteered for this research work. The guidance of Prof. K. L. Mukherjee, Professor of Biochemistry and Prof. M. K. Chhetri, former Director of Health Services, is also acknowledged.
Kumar B, Kaur I, Dogra S, Kumaran MS. Pure neuritic leprosy in India: an appraisal. Int J Lepr Other Mycobact Dis. 2004;72(3):284–90.PubMedCrossRefGoogle Scholar
Ramesh V, Porichha D. Practical problems in the management of leprosy. Lepr Rev. 1996;67(4):330–6.PubMedGoogle Scholar
Akle CA, Adinolfi M, Welsh KI, Leibowitz S, McColl I. Immunogenicity of human amniotic epithelial cells after transplantation into volunteers. Lancet. 1981;2(8254):1003–5.PubMedCrossRefGoogle Scholar
Hori J, Wang M, Kamiya K, Takahashi H, Sakuragawa N. Immunological characteristics of amniotic epithelium. Cornea. 2006;25(10 suppl 1):S53–8.PubMedCrossRefGoogle Scholar
Pruit BA, Lindberg RB. Pseudomonas aeruginosa infection on burn patients. In: Doggett RG, editor. Pseudomonas aeruginosa: clinical manifestations of infection and current therapy. 1st ed. New York: Academic; 1979. p. 339–66.Google Scholar
Miki T, Lehmann T, Cai H, et al. Stem cell characteristics of amniotic epithelial cells. Stem Cells. 2005;23:1549–59.PubMedCrossRefGoogle Scholar
Ilancheran S, Michalska A, Peh G, et al. Stem cells derived from human fetal membranes display multi-lineage differentiation potential. Biol Reprod. 2007;77:577–88.PubMedCrossRefGoogle Scholar
Portmann-Lanz CB, Schoeberlein A, Huber A, et al. Placental mesenchymal stem cells as potential autologous graft for pre- and perinatal neuroregeneration. Am J Obstet Gynecol. 2006;194:664–73.PubMedCrossRefGoogle Scholar
Kakishita K, Nakao N, Sakuragawa N, et al. Implantation of human amniotic epithelial cells prevents the degeneration of nigral dopamine neurons in rats with 6-hydroxydopamine lesions. Brain Res. 2003;980:48–56.PubMedCrossRefGoogle Scholar
Takashima S, Ise H, Zhao P, et al. Human amniotic epithelial cells possess hepatocyte-like characteristics and functions. Cell Struct Funct. 2004;29:73–84.PubMedCrossRefGoogle Scholar
Alviano F, Fossati V, Marchionni C, et al. Term amniotic membrane is a high throughput source for multipotent mesenchymal stem cells with the ability to differentiate into endothelial cells in vitro. BMC Dev Biol. 2007;7:11.PubMedCentralPubMedCrossRefGoogle Scholar
Sakuragawa N, Kakinuma K, Kikuchi A, et al. Human amnion mesenchyme cells express phenotypes of neuroglial progenitor cells. J Neurosci Res. 2004;78:208–14.PubMedCrossRefGoogle Scholar
Soncini M, Vertua E, Gibelli L, et al. Isolation and characterization of mesenchymal cells from human fetal membranes. J Tissue Eng Regen Med. 2007;1:296–305.PubMedCrossRefGoogle Scholar