Abstract
Cancer is a devastating disease with an estimated 14 million new cases occurring worldwide in 2012. This is a substantial increase from the 2008 number of 12.7 million. If these trends are projected into the future, globally, the burden of cancer will increase to 19 million new diagnoses each year by 2025. Cancer is also a leading cause of death with 8.2 million casualties (around 15 % of all deaths) in 2012, which has equally increased since 2008 [4, 5]. So evidently, despite huge efforts to tackle the disease, current treatments are largely ineffective and there is an urgent need for innovative ideas that deviate from conventional approaches.
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References
Bonadonna G (1990) Does chemotherapy fulfill its expectations in cancer treatment? Ann Oncol 1:11–21
Cuatrecasas P (2006) Drug discovery in jeopardy. J Clin Invest 116:2837–2842
Danen-Van Oorschot AA, Fischer DF, Grimbergen JM, Klein B, Zhuang S, Falkenburg JH, Backendorf C, Quax PH, Van der Eb AJ, Noteborn MH (1997) Apoptin induces apoptosis in human transformed and malignant cells but not in normal cells. Proc Natl Acad Sci U S A 94:5843–5847
Ferlay J, Soerjomataram I, Ervik M, Dikshit R, Eser S, Mathers C, Rebelo M, Parkin DM, Forman D, Bray F (2013) GLOBOCAN 2012 v1.0, cancer incidence and mortality worldwide: IARC CancerBase No. 11. International Agency for Research on Cancer, Lyon, Available from http://globocan.iarc.fr
Ferlay J, Shin HR, Bray F, Forman D, Mathers C, Parkin DM (2010) Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer 127:2893–2917
Gerlinger M, Rowan AJ, Horswell S, Larkin J, Endesfelder D, Gronroos E, Martinez P, Matthews N, Stewart A, Tarpey P et al (2012) Intratumor heterogeneity and branched evolution revealed by multiregion sequencing. N Engl J Med 366:883–892
Grimm S, Noteborn M (2010) Anticancer genes: inducers of tumour-specific cell death signalling. Trends Mol Med 16:88–96
Liang HD, Tang J, Halliwell M (2010) Sonoporation, drug delivery, and gene therapy. Proc Inst Mech Eng H J Eng Med 224:343–361
Liu C, Zhang N (2011) Nanoparticles in gene therapy principles, prospects, and challenges. Prog Mol Biol Transl Sci 104:509–562
Maruta H (2009) From chemotherapy to signal therapy (1909–2009): a century pioneered by Paul Ehrlich. Drug Discov Ther 3:37–40
Nijman SM (2011) Synthetic lethality: general principles, utility and detection using genetic screens in human cells. FEBS Lett 585:1–6
Noteborn MH, Koch G (1995) Chicken anaemia virus infection: molecular basis of pathogenicity. Avian Pathol J World Vet Poult Assoc 24:11–31
van den Berg A, Dowdy SF (2011) Protein transduction domain delivery of therapeutic macromolecules. Curr Opin Biotechnol 22:888–893
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Grimm, S. (2014). Introduction. In: Grimm, S. (eds) Anticancer Genes. Advances in Experimental Medicine and Biology, vol 818. Springer, London. https://doi.org/10.1007/978-1-4471-6458-6_1
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DOI: https://doi.org/10.1007/978-1-4471-6458-6_1
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