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Difficult Decisions in Thoracic Surgery pp 565–575Cite as

Bioengineered Tissues for Tracheal Reconstruction

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Part of the book series: Difficult Decisions in Surgery: An Evidence-Based Approach ((DDSURGERY,volume 1))

Abstract

Extended (>6 cm) reconstruction of the trachea is an unmet clinical need, and all conventional surgical approaches thus far have failed to provide any definitive solutions to this common problem. Tissue engineering, including cell-seeded scaffolds using a bioreactor, has recently became a promising therapeutic option. Despite its successful use in initial clinical compassionate cases, an understanding of the underlying mechanisms of in situ regeneration remain unclear and routine clinical applications are still far away. Early outcomes suggest that specific clinical scenarios require different approaches and additional strategies aside from tissue engineering might be necessary. There is no evidence-based medicine available for this emerging field, hence we provide an overview of hitherto investigated concepts and applied procedures.

The authors declare no competing financial interests.

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Authors and Affiliations

  1. Division of Ear, Nose, and Throat (CLINTEC), Advanced Center for Translational Regenerative Medicine (ACTREM), Karolinska Institutet, Alfred Nobels Allé 8, Huddinge, Stockholm, SE-141 86, Sweden

    Philipp Jungebluth MD & Paolo Macchiarini MD, PhD

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  1. Philipp Jungebluth MD
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  2. Paolo Macchiarini MD, PhD
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Correspondence to Paolo Macchiarini MD, PhD .

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  1. Surgery, University of Chicago, Chicago, Illinois, USA

    Mark K. Ferguson

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Jungebluth, P., Macchiarini, P. (2014). Bioengineered Tissues for Tracheal Reconstruction. In: Ferguson, M. (eds) Difficult Decisions in Thoracic Surgery. Difficult Decisions in Surgery: An Evidence-Based Approach, vol 1. Springer, London. https://doi.org/10.1007/978-1-4471-6404-3_43

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  • DOI: https://doi.org/10.1007/978-1-4471-6404-3_43

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