Skip to main content
SpringerLink
Log in

Pneumonectomy After Induction Therapy for Non-small Cell Lung Cancer

  • Chapter
  • First Online:
Difficult Decisions in Thoracic Surgery

Part of the book series: Difficult Decisions in Surgery: An Evidence-Based Approach ((DDSURGERY,volume 1))

  • 1342 Accesses

Abstract

The authors review current data on pneumonectomy in patients with non-small cell cancer after induction chemotherapy and radiation therapy and make recommendations for treatment: Evaluation by a multidisciplinary team for all advanced stage non-small cell lung cancer cases; parenchymal-conserving R0 resection for patients undergoing therapy for resectable NSCLC; pneumonectomies after induction therapy, done in experienced centers; right pneumonectomy in an experienced center after neoadjuvant therapy - if not feasible, consider referral or treatment with chemo radiotherapy.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 139.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 179.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Ginsberg RJ, Hill LD, Eagan RT, Thomas P, Mountain CF, Deslauriers J, et al. Modern thirty-day operative mortality for surgical resections in lung cancer. J Thorac Cardiovasc Surg. 1983;86(5):654–8. PubMed PMID: 6632940.

    CAS  PubMed  Google Scholar 

  2. Daly BD, Fernando HC, Ketchedjian A, Dipetrillo TA, Kachnic LA, Morelli DM, et al. Pneumonectomy after high-dose radiation and concurrent chemotherapy for nonsmall cell lung cancer. Ann Thorac Surg. 2006;82(1):227–31. PubMed PMID: 16798219.

    Article  PubMed  Google Scholar 

  3. Albain KS, Swann RS, Rusch VW, Turrisi 3rd AT, Shepherd FA, Smith C, et al. Radiotherapy plus chemotherapy with or without surgical resection for stage III non-small-cell lung cancer: a phase III randomised controlled trial. Lancet. 2009;374(9687):379–86. PubMed PMID: 19632716.

    Article  CAS  PubMed  Google Scholar 

  4. Martin J, Ginsberg RJ, Abolhoda A, Bains MS, Downey RJ, Korst RJ, et al. Morbidity and mortality after neoadjuvant therapy for lung cancer: the risks of right pneumonectomy. Ann Thorac Surg. 2001;72(4):1149–54. PubMed PMID: 11603428.

    Article  CAS  PubMed  Google Scholar 

  5. d’Amato TA, Ashrafi AS, Schuchert MJ, Alshehab DS, Seely AJ, Shamji FM, et al. Risk of pneumonectomy after induction therapy for locally advanced non-small cell lung cancer. Ann Thorac Surg. 2009;88(4):1079–85. PubMed PMID: 19766784.

    Article  PubMed  Google Scholar 

  6. Maurizi G, D’Andrilli A, Anile M, Ciccone AM, Ibrahim M, Venuta F, et al. Sleeve lobectomy compared with pneumonectomy after induction therapy for non-small-cell lung cancer. J Thorac Oncol. 2013;8(5):637–43. PubMed PMID: 23584296.

    Article  PubMed  Google Scholar 

  7. Weder W, Collaud S, Eberhardt WE, Hillinger S, Welter S, Stahel R, et al. Pneumonectomy is a valuable treatment option after neoadjuvant therapy for stage III non-small-cell lung cancer. J Thorac Cardiovasc Surg. 2010;139(6):1424–30. PubMed PMID: 20416887.

    Article  PubMed  Google Scholar 

  8. Stefani A, Alifano M, Bobbio A, Grigoroiu M, Jouni R, Magdeleinat P, et al. Which patients should be operated on after induction chemotherapy for N2 non-small cell lung cancer? Analysis of a 7-year experience in 175 patients. J Thorac Cardiovasc Surg. 2010;140(2):356–63. PubMed PMID: 20381815.

    Article  PubMed  Google Scholar 

  9. Gudbjartsson T, Gyllstedt E, Pikwer A, Jonsson P. Early surgical results after pneumonectomy for non-small cell lung cancer are not affected by preoperative radiotherapy and chemotherapy. Ann Thorac Surg. 2008;86(2):376–82. PubMed PMID: 18640300.

    Article  PubMed  Google Scholar 

  10. Cerfolio RJ, Bryant AS, Spencer SA, Bartolucci AA. Pulmonary resection after high-dose and low-dose chest irradiation. Ann Thorac Surg. 2005;80(4):1224–30. discussion 30. PubMed PMID: 16181844.

    Article  PubMed  Google Scholar 

  11. Kappers I, van Sandick JW, Burgers SA, Belderbos JS, van Zandwijk N, Klomp HM. Surgery after induction chemotherapy in stage IIIA-N2 non-small cell lung cancer: why pneumonectomy should be avoided. Lung Cancer. 2010;68(2):222–7. PubMed PMID: 19664843.

    Article  PubMed  Google Scholar 

  12. Alifano M, Boudaya MS, Salvi M, Collet JY, Dinu C, Camilleri-Broet S, et al. Pneumonectomy after chemotherapy: morbidity, mortality, and long-term outcome. Ann Thorac Surg. 2008;85(6):1866–72. discussion 72–3. PubMed PMID: 18498785.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Division of Cardiothoracic Surgery, University of North Carolina at Chapel Hill, 3040 Burnett-Womack Building, CB #7065, Chapel Hill, NC, 27599-7065, USA

    Benjamin E. Haithcock MD

  2. Division of Cardiothoracic Surgery, Department of Surgery, University of North Carolina, 3040 Burnett-Womack Building, CB #7065, Chapel Hill, NC, 27599-7065, USA

    Richard H. Feins MD

Authors
  1. Benjamin E. Haithcock MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Richard H. Feins MD
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Benjamin E. Haithcock MD .

Editor information

Editors and Affiliations

  1. Surgery, University of Chicago, Chicago, Illinois, USA

    Mark K. Ferguson

Rights and permissions

Reprints and permissions

Copyright information

© 2014 Springer-Verlag London

About this chapter

Cite this chapter

Haithcock, B.E., Feins, R.H. (2014). Pneumonectomy After Induction Therapy for Non-small Cell Lung Cancer. In: Ferguson, M. (eds) Difficult Decisions in Thoracic Surgery. Difficult Decisions in Surgery: An Evidence-Based Approach, vol 1. Springer, London. https://doi.org/10.1007/978-1-4471-6404-3_14

Download citation

  • DOI: https://doi.org/10.1007/978-1-4471-6404-3_14

  • Published:

  • Publisher Name: Springer, London

  • Print ISBN: 978-1-4471-6403-6

  • Online ISBN: 978-1-4471-6404-3

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation