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Tropical Viral CNS Infections

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CNS Infections

Abstract

Viral infections of the CNS in the tropics and Indian subcontinent are not only different from that encountered in the western world, but many types are constantly emerging. While age-old scourges like polio have recently been contained in these geographical areas to a great extent, thanks to effective vaccination programs, others like Japanese encephalitis, rabies, and measles in the form of subacute sclerosing panencephalitis have been inadequately controlled. In recent times some viruses causing predominant CNS symptoms such as West Nile, Chandipura, and Nipah have emerged. Emerging viruses also include others that may occasionally cause CNS symptoms such as enterovirus, dengue, and chikungunya. The CNS manifestations of most of these viruses may be in the form of aseptic meningitis, encephalitis, or myelitis either in isolated form or in combination. Many of these viruses such as Japanese encephalitis cause large-scale epidemics with high mortality and morbidity. This chapter discusses the current status of many of these viral infections of the CNS predominant in these geographical areas.

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References

  1. Kumar R. Aseptic meningitis: diagnosis and management. Indian J Pediatr. 2005;72(1):57–63.

    Article  PubMed  Google Scholar 

  2. Sathish N, Scott JX, Shaji RV, et al. An outbreak of echoviral meningitis in children. Indian Pediatr. 2004;41(4):384–8.

    PubMed  Google Scholar 

  3. Handique SK. Viral infections of the central nervous system. Neuroimaging Clin N Am. 2011;21:777–94.

    Article  PubMed  Google Scholar 

  4. Wang RJ, Wang DX, Wang JW, Feng ZJ. Analysis of 62 adult patients with viral meningitis. Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 2009;23(3):218–20.

    PubMed  Google Scholar 

  5. Jmor F, Emsley HC, Fischer M, Solomon T, Lewthwaite P. The incidence of acute encephalitis syndrome in Western industrialised and tropical countries. Virol J. 2008;5:134.

    Article  PubMed Central  PubMed  Google Scholar 

  6. Joshi R, Mishra PK, Joshi D, et al. Clinical presentation, etiology, and survival in adult acute encephalitis syndrome in rural Central India. Clin Neurol Neurosurg. 2013. doi:http://dx.doi.org/10.1016/j.clineuro.2013.04.008.

    Google Scholar 

  7. Joshi R, Kalantri SP, Reingold A, et al. Changing landscape of acute encephalitis syndrome in India: a systematic review. Natl Med J India. 2012;25:212–20.

    PubMed  Google Scholar 

  8. Booss J, Esiri MM. Pathological features of encephalitis in humans. In: Booss J, Esiri MM, editors. Viral encephalitis in humans. Washington, DC: ASM Press; 2013. p. 3–19.

    Google Scholar 

  9. Solomon T, Dung NM, Kneen R, et al. Japanese encephalitis. J Neurol Neurosurg Psychiatry. 2000;68:405–41.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  10. Burke DS, Leake CJ. Japanese encephalitis. In: Monath TP, editor. The Arboviruses: epidemiology and ecology, vol. 3. Boca Raton: CRC Press; 1988. p. 63–92.

    Google Scholar 

  11. Campbell GL, Hills SL, Fischer M, et al. Estimated global incidence of Japanese encephalitis: a systematic review. Bull World Health Organ. 2011;89:766–4E. doi:10.2471/BLT.10.085233.

    Article  PubMed Central  PubMed  Google Scholar 

  12. Solomon T. Recent advances in Japanese encephalitis. J Neurovirol. 2003;9:274–83.

    Article  CAS  PubMed  Google Scholar 

  13. Chen WR, Tesh RB, Rico-Hesse R. Genetic variation of Japanese encephalitis virus in nature. J Gen Virol. 1990;71:2915–22.

    Article  CAS  PubMed  Google Scholar 

  14. Chen WR, Rico-Hesse R, Tesh RB. A new genotype of Japanese encephalitis virus from Indonesia. Am J Trop Med Hyg. 1992;47(1):61–9.

    CAS  PubMed  Google Scholar 

  15. Uchil PD, Satchidanandam V. Phylogenetic analysis of Japanese encephalitis virus: envelope gene based analysis reveals a fifth genotype, geographic clustering, and multiple introductions of the virus into the Indian subcontinent. Am J Trop Med Hyg. 2001;65:242–51.

    CAS  PubMed  Google Scholar 

  16. Tiwari S, Singh RK, Tiwari R, et al. Japanese encephalitis: a review of the Indian perspective. Braz J Infect Dis. 2012;16:564–73.

    Article  PubMed  Google Scholar 

  17. Kanojia PC, Shetty PS, Geevarghese G. A long-term study on vector abundance & seasonal prevalence in relation to the occurrence of Japanese encephalitis in Gorakhpur district, Uttar Pradesh. Indian J Med Res. 2003;117:104–10.

    CAS  PubMed  Google Scholar 

  18. Vaughn DW, Hoke Jr CH. The epidemiology of Japanese encephalitis: prospects for prevention. Epidemiol Rev. 1992;14:197–221.

    CAS  PubMed  Google Scholar 

  19. Umenai T, Krzysko R, Bektimorov TA, et al. Japanese encephalitis: current worldwide status. Bull World Health Organ. 1985;63:625–31.

    CAS  PubMed Central  PubMed  Google Scholar 

  20. Huong VTQ, Ha DQ, Deubel V. Genetic study of Japanese encephalitis viruses from Vietnam. Am J Trop Med Hyg. 1993;49:538–44.

    CAS  PubMed  Google Scholar 

  21. Misra UK, Kalita J. Overview: Japanese encephalitis. Prog Neurobiol. 2010;91:108–20.

    Article  CAS  PubMed  Google Scholar 

  22. Bai L, Morton LC, Liu Q. Climate change and mosquito borne diseases in China: a review. Global Health. 2013;9:10. doi:10.1186/1744-8603-0-10.

    Article  PubMed Central  PubMed  Google Scholar 

  23. NVBDC P. Directorate General of Health Services. Ministry of Health and Family Welfare. New Delhi. 2010. Available from http://nvbdcp.gov.in/je-cd.html.

  24. Dutta K, Rangarajan PN, Vrati S, et al. Japanese encephalitis: pathogenesis, prophylactics and therapeutics. Curr Sci. 2010;98:326–34.

    CAS  Google Scholar 

  25. Diamond MS. Evasion of innate and adaptive immunity by flaviviruses. Immunol Cell Biol. 2003;81:196–206.

    Article  PubMed  Google Scholar 

  26. Shankar SK, Vasudev Rao T, Mruthyunjayanna BP, et al. Autopsy study of brains during an epidemic of Japanese encephalitis in Karnataka. Indian J Med Res. 1983;78:431–40.

    CAS  PubMed  Google Scholar 

  27. Zimmerman HM. The pathology of Japanese B encephalitis. Am J Pathol. 1946;22:965–91.

    PubMed Central  Google Scholar 

  28. Gourie-Devi M, Ravi V, Shankar SK. Japanese encephalitis. An overview. In: Clifford Rose F, editor. Recent advances in tropical neurology. Amsterdam: Elsevier Science B.V.; 1995. p. 17–35.

    Google Scholar 

  29. Tiroumourougane SV, Raghava P, Srinivasan S. Japanese viral encephalitis. Postgrad Med J. 2002;78:205–15.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  30. Kumar R, Mathur A, Kumar A, et al. Clinical features & prognostic indicators of Japanese encephalitis in children in Lucknow (India). Indian J Med Res. 1990;91:321–7.

    CAS  PubMed  Google Scholar 

  31. Solomon T, Kneen R, Dung NM, et al. Poliomyelitis-like illness due to Japanese encephalitis like virus. Lancet. 1998;351:1094–7.

    Article  CAS  PubMed  Google Scholar 

  32. Pradhan S, Gupta RK, Singh MB, et al. Biphasic illness pattern due to early relapse in Japanese-B virus encephalitis. J Neurol Sci. 2001;183:13–8.

    Article  CAS  PubMed  Google Scholar 

  33. Handique SK, Barkataky N. MR imaging in biphasic Japanese encephalitis. AJNR Am J Neuroradiol. 2008;29:E3.

    Article  CAS  PubMed  Google Scholar 

  34. Kalita K, Misra UK. EEG in Japanese encephalitis: a clinico-radiological correlation. Electroencephalogr Clin Neurophysiol. 1998;106:238–43.

    Article  CAS  PubMed  Google Scholar 

  35. Kalita J, Misra UK. Comparison of CT scan and MRI findings in the diagnosis of Japanese encephalitis. J Neurol Sci. 2000;174:3–8.

    Article  CAS  PubMed  Google Scholar 

  36. Handique SK, Das RR, Barman K, et al. Temporal lobe involvement in Japanese encephalitis – problems in differential diagnosis. AJNR Am J Neuroradiol. 2006;27:1027–31.

    CAS  PubMed  Google Scholar 

  37. Shoji H, Kida H, Hino H, et al. Magnetic resonance imaging findings in Japanese encephalitis. White matter lesions. J Neuroimaging. 1994;4:206–11.

    CAS  PubMed  Google Scholar 

  38. Dung NM, Turtle L, Chong WK, et al. An evaluation of the usefulness of neuroimaging for the diagnosis of Japanese encephalitis. J Neurol. 2009;256:2052–60.

    Article  CAS  PubMed  Google Scholar 

  39. Basumatary LJ, Raja D, Bhuyan D, et al. Clinical and radiological spectrum of Japanese encephalitis. J Neurol Sci. 2013;325:15–21.

    Article  PubMed  Google Scholar 

  40. Burke DS, Nisalak A, Ussery MA. Antibody capture immunoassay detection of Japanese encephalitis virus immunoglobulin M and G antibodies in cerebrospinal fluid. J Clin Microbiol. 1982;16:1034–42.

    CAS  PubMed Central  PubMed  Google Scholar 

  41. Solomon T, Dung NM, Wills B, et al. Interferon alfa-2a in Japanese encephalitis: a randomised double-blind placebo-controlled trial. Lancet. 2003;361:821–6.

    Article  CAS  PubMed  Google Scholar 

  42. Saxena SK, Mathur A, Srivastava RC. Inhibition of Japanese encephalitis virus infection by diethyldithiocarbamate is independent of its antioxidant potential. Antivir Chem Chemother. 2003;14:91–8.

    CAS  PubMed  Google Scholar 

  43. Hoke Jr CH, Vaughn DW, Nisalak A, et al. Effect of high dose dexamethasone on the outcome of acute encephalitis due to Japanese encephalitis virus. J Infect Dis. 1992;165:631–7.

    Article  PubMed  Google Scholar 

  44. Dutta K, Basu A. Use of minocycline in viral infections. Indian J Med Res. 2011;133:467–70.

    PubMed Central  PubMed  Google Scholar 

  45. Sebastian L, Desai A, Shampur MN, et al. N-methylisatin-beta thiosemicarbazone derivative (Sch 16) is an inhibitor of Japanese encephalitis virus infection in vitro and in vivo. Virol J. 2008;5:64.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  46. Rossi SL, Ross TM, Evans JD. West Nile virus. Clin Lab Med. 2010;30:47–65.

    Article  PubMed Central  PubMed  Google Scholar 

  47. Paramasivan R, Mishra AC, Mourya DT. West Nile virus: the Indian scenario. Indian J Med Res. 2003;118:101–8.

    CAS  PubMed  Google Scholar 

  48. Gajanana A. West Nile virus epidemics: lessons for India. ICMR Bull. 2002;32(7).

    Google Scholar 

  49. World Health Organisation. West Nile Virus. Media centre. Fact sheet, July 2011. [Internet] 2013 [cited 2013 June 19]. Available from http://www.who.int/mediacentre/factsheets/fs354/en/#.

  50. Banker DD. Preliminary observations on antibody patterns against certain viruses among inhabitants of Bombay city. Indian J Med Sci. 1952;6:733–46.

    Google Scholar 

  51. Khan SA, Dutta P, Khan AM, et al. West Nile virus, Assam, India. Emerg Infect Dis. 2011;17:947–8.

    Article  PubMed Central  PubMed  Google Scholar 

  52. Samuel MA, Diamond MS. Pathogenesis of West Nile Virus infection: a balance between virulence, innate and adaptive immunity, and viral evasion. J Virol. 2006;80:9349–60.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  53. Sampson BA, Ambrosi C, Charlot C, et al. The pathology of human West Nile Virus infection. Hum Pathol. 2000;31:527–31.

    Article  CAS  PubMed  Google Scholar 

  54. Kelly TW, Prayson RA, Ruiz AI, et al. The neuropathology of West Nile virus meningoencephalitis: a report of 2 cases and review of the literature. Am J Clin Pathol. 2003;119:749–53.

    Article  Google Scholar 

  55. Zak IT, Altinok D, Merline JR, et al. West Nile virus infection. AJR Am J Roentgenol. 2005;184:957–61.

    Article  PubMed  Google Scholar 

  56. Ali M, Safriel Y, Sohi J, et al. West Nile virus infection: MR imaging findings in the nervous system. AJNR Am J Neuroradiol. 2005;26:289–97.

    PubMed  Google Scholar 

  57. Petropoulou KA, Gordon SM, Prayson RA, et al. West Nile virus meningoencephalitis: MR imaging findings. AJNR Am J Neuroradiol. 2005;26:1986–95.

    PubMed  Google Scholar 

  58. World Health Organisation. Dengue: guidelines for diagnosis, treatment, prevention and control. Geneva: WHO; 2009.

    Google Scholar 

  59. World Health Organization. Dengue haemorrhagic fever; diagnosis, treatment, prevention and control. Geneva: WHO; 1997.

    Google Scholar 

  60. Gulati S, Maheshwari A. Atypical manifestations of dengue. Trop Med Int Health. 2007;12:1087–95.

    Article  PubMed  Google Scholar 

  61. Murthy JMK. Neurological manifestations of dengue infection. Neurol India. 2010;58:581–4.

    Article  CAS  PubMed  Google Scholar 

  62. Varatharaj A. Encephalitis in the clinical spectrum of dengue infection. Neurol India. 2010;58:585–91.

    Article  PubMed  Google Scholar 

  63. World Health Organisation. Media centre. Poliomyelitis. Available at. http://www.who.int/mediacentre/factsheets/fs114/en/. Accessed 5 July 2013.

  64. Tyler KL. Emerging viral infections of the central nervous system: part 1. Arch Neurol. 2009;66:939–48.

    PubMed Central  PubMed  Google Scholar 

  65. Sarma N. Hand, foot, and mouth disease: current scenario and Indian perspective. Indian J Dermatol Venereol Leprol. 2013;79:165–75.

    Article  PubMed  Google Scholar 

  66. Shen WC, Chiu HH, Chow KC, et al. MR Imaging findings of enteroviral encephalomyelitis: an outbreak in Taiwan. AJNR Am J Neuroradiol. 1999;20:1889–95.

    CAS  PubMed  Google Scholar 

  67. Karmarkar SA, Aneja S, Khare S, et al. A study of acute febrile encephalopathy with special reference to viral etiology. Indian J Pediatr. 2008;75:801–5.

    Article  CAS  PubMed  Google Scholar 

  68. Lewthwaite P, Perera D, Ooi MH, Last A, Kumar R, Desai A, et al. Enterovirus 75 encephalitis in children, southern India. Emerg Infect Dis [serial on the Internet]. 2010 Nov [date cited]. http://www.cdc.gov/EID/content/16/11/1780.htm. doi: 10.3201/eid1611.100672.

    Google Scholar 

  69. Sapkal GN, Bondre VP, Fulmali PV, Patil P, Gopalkrishna V, Dadhania V, et al. Enteroviruses in patients with acute encephalitis, Uttar Pradesh, India. Emerg Infect Dis. 2009;15:295–8.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  70. Laxmivandana R, Yergolkar P, Gopalkrishna V, et al. Characterization of the non-polio enterovirus infections associated with acute flaccid paralysis in South-Western India. PLoS ONE. 2013;8(4):e61650. doi:10.1371/journal.pone.0061650.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  71. Nipah virus factsheet (revised in July 2009). Wkly Epidemiol Rec. 2010;85:64–67.

    Google Scholar 

  72. Tyler KL. Emerging viral infections of the central nervous system: part 2. Arch Neurol. 2009;66:1065–74.

    PubMed Central  PubMed  Google Scholar 

  73. Lo MK, Rota PA. The emergence of Nipah virus, a highly pathogenic paramyxovirus. J Clin Virol. 2008;43:396–400.

    Article  CAS  PubMed  Google Scholar 

  74. Goh KJ, Tan CT, Chew NK, et al. Clinical features of Nipah virus encephalitis among pig farmers in Malaysia. N Engl J Med. 2000;342:1229–35.

    Article  CAS  PubMed  Google Scholar 

  75. Hossain MJ, Gurley ES, Montgomery JM, et al. Clinical presentation of Nipah virus infection in Bangladesh. Clin Infect Dis. 2008;46:977–84.

    Article  PubMed  Google Scholar 

  76. Tan CT, Goh KJ, Wong KT, et al. Relapsed and late-onset Nipah encephalitis. Ann Neurol. 2002;51:703–8.

    Article  PubMed  Google Scholar 

  77. Sejvar JJ, Hossain J, Saha SK, et al. Long-term neurological and functional outcome in Nipah virus infection. Ann Neurol. 2007;62:235–42.

    Article  PubMed  Google Scholar 

  78. Sarji SA, Abdullah BJJ, Goh KJ, et al. MR imaging features of Nipah encephalitis. Am J Roentgenol. 2000;175:437–42.

    Article  CAS  Google Scholar 

  79. Lim CC, Lee KE, Lee WL, et al. Nipah virus encephalitis: serial MR study of an emerging disease. Radiology. 2002;222:219–26.

    Article  PubMed  Google Scholar 

  80. Quddus R, Alam S, Majumdar SA, et al. A report of 4 patients with Nipah encephalitis from Rajbari district, Bangladesh in the January 2004 outbreak. Neurol Asia. 2004;9:33–7.

    Google Scholar 

  81. Madhusudana SN, Sukumaran SM. Antemortem diagnosis and prevention of human rabies. Ann Indian Acad Neurol. 2008;11:3–12.

    Article  PubMed Central  PubMed  Google Scholar 

  82. WHO Factsheet. Rabies. Available at http://www.who.int/mediacentre/factsheets/fs099/en/. Accessed 3 Nov 2013.

  83. Sudarshan MK. Assessing burden of rabies in India. WHO sponsored national multi-centric rabies survey (May 2004). Assoc Prev Control Rabies India J. 2004;6:44–5.

    Google Scholar 

  84. Laothamatas J, Hemachuda T, Mitrabhakdi PW, et al. MR imaging in human rabies. AJNR Am J Neuroradiol. 2003;24:1102–9.

    PubMed  Google Scholar 

  85. World Health Organization. Rabies. Guide for post exposure prophylaxis. Available at http://www.who.int/rabies/human/postexp/en/#. Accessed 3 Nov 2013.

  86. WHO guide for rabies pre and post-exposure prophylaxis in humans (revised 15 June 2010). Available at http://www.who.int/rabies/PEP_prophylaxis_guidelines_June10.pdf. Accessed 3 Nov 2013.

  87. WHO: Measles deaths decline, but elimination progress stalls in some regions. Available at http://www.who.int/mediacentre/news/notes/2013/measles_20130117/en/. Accessed 3 Nov 2013.

  88. Simons E, Ferrari M, Fricks J, et al. Assessment of the 2010 global measles mortality reduction goal: results from a model of surveillance data. Lancet. 2012;379(9832):2173–8. doi:10.1016/S0140-6736(12)60522-4. Epub 2012 Apr 24.

    Article  PubMed  Google Scholar 

  89. Hosoya M. Measles encephalitis: direct viral invasion or autoimmune-mediated inflammation? Intern Med. 2006;45:841–2.

    Article  PubMed  Google Scholar 

  90. Beig FK, Malik A, Rizvi M, et al. Etiology and clinic-epidemiological profile of acute viral encephalitis in children of western Uttar Pradesh, India. Int J Infect Dis. 2010;14:e141–6.

    Article  PubMed  Google Scholar 

  91. Saha V, John TJ, Mukundan P, et al. High incidence of subacute sclerosing panencephalitis in South India. Epidemiol Infect. 1990;104:151–6.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  92. Garg RK, Karak B, Sharma AM. Subacute sclerosing panencephalitis. Indian Pediatr. 1998;35:337–44.

    CAS  PubMed  Google Scholar 

  93. Mishra B, Kakkar N, Ratho RK, et al. Changing trend of SSPE over a period of 10 years. Indian J Public Health. 2005;49:235–7.

    CAS  PubMed  Google Scholar 

  94. Fernandez-Muñoz R, Carabaña J, Caballero M, Ortego J, et al. Subacute sclerosing panencephalitis and other lethal encephalitis caused by measles virus infection: pathogenesis and new approaches to treatment, non-flavivirus encephalitis. Dr. Sergey Tkachev, editor. InTech; 2011. ISBN 978-953-307-720-8. Available from http://www.intechopen.com/books/non-flavivirus-encephalitis/subacutesclerosing-panencephalitis-and-other-lethal-encephalitis-caused-by-measles-virus-infection. Accessed 5 Aug 2013.

  95. Lee KY, Cho WH, Kim SH, et al. Acute encephalitis associated with measles: MRI features. Neuroradiology. 2003;45:100–6.

    Article  CAS  PubMed  Google Scholar 

  96. Gutierrez J, Issacson RS, Koppel BS. Subacute sclerosing panencephalitis: an update. Dev Med Child Neurol. 2010;52:901–7.

    Article  PubMed  Google Scholar 

  97. Garg RK. Subacute sclerosing panencephalitis. Postgrad Med J. 2002;78:63–70.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  98. Esiri MM, Kennedy PG. Virus diseases. In: Adams JH, Duchen LW, editors. Greenfield’s neuropathology. 5th ed. London: Edward Arnold; 1992. p. 335–99.

    Google Scholar 

  99. Jabbour JT, Garcia JH, Lemmi H, et al. Subacute sclerosing panencephalitis: a multidisciplinary study of eight cases. JAMA. 1969;207:2248–54.

    Article  CAS  PubMed  Google Scholar 

  100. Brismar J, Gascon GG, von Steyern KV, et al. Subacute sclerosing panencephalitis: evaluation with CT and MR. AJNR Am J Neuroradiol. 1996;17:761–72.

    CAS  PubMed  Google Scholar 

  101. Tuncay R, Akman-Demir G, Gokygit A, et al. MRI in subacute sclerosing panencephalitis. Neuroradiology. 1996;38:636–40.

    Article  CAS  PubMed  Google Scholar 

  102. Sener RN. Subacute sclerosing panencephalitis findings at MR imaging, diffusion MR imaging, and proton MR spectroscopy. AJNR Am J Neuroradiol. 2004;25:892–4.

    PubMed  Google Scholar 

  103. Alkan A, Korkmaz L, Sigirci A, et al. Subacute sclerosing panencephalitis: relationship between clinical stage and diffusion-weighted imaging findings. J Magn Reson Imaging. 2006;23:267–72.

    Article  PubMed  Google Scholar 

  104. Alkan A, Sarac K, Kutlu R, et al. Early- and late subacute sclerosing pan encephalitis: chemical shift imaging and single-voxel MR spectroscopy. AJNR Am J Neuroradiol. 2003;24:501–6.

    PubMed  Google Scholar 

  105. Trivedi R, Gupta RK, Agarawal A, et al. Assessment of white matter damage in subacute sclerosing panencephalitis using quantitative diffusion tensor MR imaging. AJNR Am J Neuroradiol. 2006;27:1712–6.

    CAS  PubMed  Google Scholar 

  106. Trivedi R, Anuradha H, Agarwal A, et al. Correlation of quantitative diffusion tensor tractography with clinical grades of subacute sclerosing panencephalitis. AJNR Am J Neuroradiol. 2011;32:714–20.

    Article  CAS  PubMed  Google Scholar 

  107. Garg RK. Subacute sclerosing panencephalitis. J Neurol. 2008;255:1861–71.

    Article  PubMed  Google Scholar 

  108. Panitch HS, Gomez-Plascencia J, Noris FS, et al. Subacute sclerosing panencephalitis remission after treatment with interferon. Neurology. 1986;36:562–6.

    Article  CAS  PubMed  Google Scholar 

  109. Gascon GG. International Consortium on Subacute Sclerosing Panencephalitis. Randomized treatment study of inosiplex versus combined inosiplex and intraventricular interferon-alpha in subacute sclerosing panencephalitis (SSPE): international multicenter study. J Child Neurol. 2003;18:819–27.

    Article  PubMed  Google Scholar 

  110. Hosoya M, Shigeta S, Mori S, et al. High-dose intravenous ribavirin therapy for subacute sclerosing panencephalitis. Antimicrob Agents Chemother. 2001;45:943–5.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  111. Hara S, Kimura H, Hoshino Y, et al. Combination therapy with intraventricular interferon-alpha and ribavirin for subacute sclerosing panencephalitis and monitoring measles virus RNA by quantitative PCR assay. Brain Dev. 2003;25:367–9.

    Article  PubMed  Google Scholar 

  112. Mustafa MM, Weitman SD, Winick NJ, et al. Subacute measles encephalitis in young immunocompromised host: a review of two cases diagnosed by polymerase chain reaction and treated with ribavirin and review of the literature. Clin Infect Dis. 1993;16:654–60.

    Article  CAS  PubMed  Google Scholar 

  113. Albertyn C, van der Plas H, Hardie D, et al. Silent casualties from the measles outbreak in South Africa. S Afr Med J. 2011;101(5):313–4, 316–7.

    PubMed  Google Scholar 

  114. Hardie DR, Albertyn C, Heckmann JM, et al. Molecular characterisation of virus in the brains of patients with measles inclusion body encephalitis (MIBE). Virol J. 2013;10(1):283.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  115. Poon TP, Tchertkoff V, Win H. Subacute measles encephalitis with AIDS diagnosed by fine needle aspiration biopsy. A case report. Acta Cytol. 1998;42:729–33.

    Article  CAS  PubMed  Google Scholar 

  116. Chong HT, Ramli N, Wong KT, et al. Subacute measles encephalitis: a case of long term survival with follow-up MR brain scans. Neurol Asia. 2007;12:121–5.

    Google Scholar 

  117. John TJ. Chandipura virus – what we know & do not know. Indian J Med Res. 2010;132:125–7.

    Google Scholar 

  118. Chandipura encephalitis. Available at http://icmr.nic.in/pinstitute/niv/CHANDIPURA%20ENC.pdf. Accessed 3 Nov 2013.

  119. Rao BL, Basu A, Wairagkar NS, Gore MM, et al. A large outbreak of acute encephalitis with high fatality rate in children in Andhra Pradesh, India. Lancet. 2004;364:869–74.

    Article  CAS  PubMed  Google Scholar 

  120. Chadha MS, Arankalle VA, Jadi RS, et al. An outbreak of Chandipura virus encephalitis in the eastern districts of Gujarat state, India. Am J Trop Med Hyg. 2005;73:566–70.

    PubMed  Google Scholar 

  121. Rao PN, Kumar PA, Rao TA, et al. Role of Chandipura virus in an “epidemic brain attack” in Andhra Pradesh, India. J Pediatr Neurol. 2004;2:131–43.

    Google Scholar 

  122. Rao NS, Wairagkar NS, Mohan MV, et al. Brain stem encephalitis associated with Chandipura virus in Andhra Pradesh outbreak. J Trop Pediatr. 2008;54:25–30.

    Google Scholar 

  123. Gurav YK, Tandale BV, Jadi RS, et al. Chandipura virus encephalitis outbreak among children in Nagpur division, Maharashtra, 2007. Indian J Med Res. 2010;132:395–9.

    PubMed  Google Scholar 

  124. Kumar S, Jadi RS, Anakkathil SB, Tandale BV, Mishra AC, Arankalle VA. Development and evaluation of a real-time one step reverse-transcriptase PCR for quantitation of Chandipura Virus. BMC Infect Dis. 2008;8:168–74.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  125. Mishra AC. Chandipura virus, encephalitis, and epidemic brain attack in India. Lancet. 2004;364(9452):2175–6.

    Article  Google Scholar 

  126. Tandale BV, Tikute SS, Arankalle VA, et al. Chandipura virus: a major cause of acute encephalitis in children in North Telangana, Andhra Pradesh, India. J Med Virol. 2008;80(1):118–24.

    Article  PubMed  Google Scholar 

  127. Jacob JT. Chandipura Virus, encephalitis and epidemic brain attack in India. Lancet. 2004;364:2175.

    Article  Google Scholar 

  128. Tsetsarkin KA, Vanlandingham DL, McGee CE, Higgs S. A single mutation in chikungunya virus affects vector specificity and epidemic potential. PLoS Pathog. 2007;3(12):e201. PubMed: 18069894.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  129. Wadia RS. A neurotropic virus (chikungunya) and a neuropathic amino acid (homocysteine). Ann Indian Acad Neurol. 2007;10:198–213.

    Google Scholar 

  130. Tournebize P, Charlin C, Lagrange M. Neurological manifestations in Chikungunya: about 23 cases collected in Reunion Island [in French]. Rev Neurol (Paris). 2009;165(1):48–51. PubMed: 18835614.

    Article  CAS  Google Scholar 

  131. Robin S, Ramful D, Le Seach F, Jaffar-Bandjee MC, Rigou G, Alessandri JL. Neurologic manifestations of pediatric chikungunya infection. J Child Neurol. 2008;23(9):1028–35. PubMed: 18287573.

    Article  PubMed  Google Scholar 

  132. Ganesan K, Diwan A, Shankar SK, et al. Chikungunya encephalomyeloradiculitis: report of 2 cases with neuroimaging and 1 case with autopsy findings. AJNR Am J Neuroradiol. 2008;29:1636–7.

    Article  CAS  PubMed  Google Scholar 

  133. Marx A, Glass JD, Sutter RW. Differential diagnosis of acute flaccid paralysis and its role in poliomyelitis surveillance. Epidemiol Rev. 2000;22(2):298–316.

    Article  CAS  PubMed  Google Scholar 

  134. Kincaid O, Lipton HL. Viral myelitis: an update. Curr Neurol Neurosci Rep. 2006;6:469–74.

    Article  PubMed  Google Scholar 

  135. World Health organization. Weekly epidemiological record. 2013;88:381–8.

    Google Scholar 

  136. Chen CY, Chang YC, Huang CC, et al. Acute flaccid paralysis in infants and young children with enterovirus 71 infection: MR imaging findings and clinical correlates. AJNR Am J Neuroradiol. 2001;22(1):200–5.

    CAS  PubMed  Google Scholar 

  137. Malzberg MS, Rogg JM, Tate CA, et al. Poliomyelitis: hyperintensity of the anterior horn cells on MR images of the spinal cord. Am J Roentgenol. 1993;161(4):863–5.

    Article  CAS  Google Scholar 

  138. Kumar S, Misra UK, Kalita J, et al. MRI in Japanese encephalitis. Neuroradiology. 1997;39:180–4.

    Article  CAS  PubMed  Google Scholar 

  139. Davies NW, Brown LJ, Irish D, et al. Factors influencing PCR detection of viruses in cerebrospinal fluid of patients with suspected CNS infections. J Neurol Neurosurg Psychiatry. 2005;76:82–7.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  140. Gorson K, Ropper A. Nonpoliovirus poliomyelitis simulating Guillain-Barré syndrome. Arch Neurol. 2001;58:1460–4.

    Article  CAS  PubMed  Google Scholar 

  141. Asbury A, Arnason B, Karp H. Criteria for diagnosis of Guillain-Barré syndrome. Ann Neurol. 1978;3:565–6.

    Article  Google Scholar 

  142. Starlin R, Reed N, Leeman B. Acute flaccid paralysis syndrome associated with echovirus 19 managed with pleconaril and intravenous immunoglobulin. Clin Infect Dis. 2001;33:730–2.

    Article  CAS  PubMed  Google Scholar 

  143. Shimoni Z, Niven MJ, Pitlick S, et al. Treatment of West Nile virus encephalitis with intravenous immunoglobulin. Emerg Infect Dis. 2001;7:759.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  144. Rao AS, Varma DR, Chalapathi Rao MV, et al. Case report: magnetic resonance imaging in rabies encephalitis. Indian J Radiol Imaging. 2009;19:301–4.

    Article  PubMed Central  PubMed  Google Scholar 

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Handique, S.K., Barthakur, M. (2014). Tropical Viral CNS Infections. In: García-Moncó, J. (eds) CNS Infections. Springer, London. https://doi.org/10.1007/978-1-4471-6401-2_6

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