CNS Infections pp 227-247 | Cite as


  • Juan C. SalazarEmail author


Syphilis is a sexually transmitted infection caused by the spirochetal bacterium Treponema pallidum, subspecies pallidum. During early syphilis, the spirochete has the ability to disseminate into the central nervous system and cause both symptomatic and asymptomatic meningitis and in more severe cases vasculitis leading to thrombosis, ischemia, and even death. During tertiary syphilis, the chronic inflammatory responses to the spirochete can severely compromise the brain parenchyma and the spinal cord, leading to paresis and tabes dorsalis. In this chapter we will review the clinical presentation, diagnostic criteria, and treatment modalities for neurosyphilis.


Treponema pallidum Neurosyphilis Meningitis Meningovascular syphilis Gumma Paresis Tabes dorsalis 


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© Springer-Verlag London 2014

Authors and Affiliations

  1. 1.Department of PediatricsConnecticut Children’s Medical CenterHartfordUSA

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