Treatment of Parkinsonism in Patients with Non-Parkinson Dementia
Parkinsonism and dementia can co-occur in patients without Parkinson’s disease, and most of patients with neurodegenerative parkinsonism develop significant cognitive impairment. Parkinsonism–dementia syndromes notably include dementia with Lewy bodies, progressive supranuclear palsy, corticobasal syndrome, normal-pressure hydrocephalus, vascular parkinsonism and dementia, drug-induced parkinsonism and dementia, frontotemporal lobe dementia, and Alzheimer’s disease. Therapeutic options for parkinsonism in these patients are limited, and data are scarce. In this chapter, we summarize the available information on this topic.
KeywordsParkinsonism Dementia Treatment Dementia with Lewy bodies Progressive supranuclear palsy Corticobasal syndrome Normal-pressure hydrocephalus Frontotemporal lobe dementia Alzheimer’s disease
- Fernandez HH, Rodriguez RL, Skidmore FM, Okun MS. A practical approach to any movement disorder: diagnosis, medical and surgical management. New York: Demos Publishing, Inc; 2007.Google Scholar
- Golbe LI, Sage JI, Duvoisin RC. Drug treatment of 83 patients with progressive supranuclear palsy. Neurology. 1990;40:438.Google Scholar
- Irene L, Yves A, editors. Progressive supranuclear palsy: clinical and research approaches. New York: Oxford University Press; 1992.Google Scholar
- McKeith IG, Dickson DW, Lowe J, Emre M, O’Brien JT, Feldman H, et al., Consortium on DLB. Diagnosis and management of dementia with Lewy bodies: third report of the DLB Consortium. Neurology. 2005;65(12):1863–72.Google Scholar
- Rascol O, Brooks DJ, Korczyn AD, De Deyn PP, Clarke CE, Lang AE. A five-year study of the incidence of dyskinesia in patients with Parkinson’s disease who were treated with ropinirole or levodopa. 056 Study Group. N Engl J Med. 2000;18(342):1481–91.Google Scholar
- Zupancic M, Mahajan A, Handa K. Dementia with Lewy bodies: diagnosis and management for primary care providers. Prim Care Companion CNS Disord. 2011;13(5). pii: PCC.11r01190. doi: 10.4088/PCC.11r01190. PMID:22295275.