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Standard Cremaster Muscle Model for Ischemia Reperfusion

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Plastic and Reconstructive Surgery

Abstract

Ischemia – reperfusion injury (IRI) is a serious complication of revascularisation that biases a result of many surgical procedures. The pathophysiology of IRI is very complex and still not fully understood. For years a laboratory model of muscle ischemia reperfusion have been developed to provide reliable scientific tool for observation of IRI and investigation of possible therapeutic strategies. Cremaster muscle model of IRI plays an important role in research of IRI due to its similarity to clinical scenarios of limb ischemia, transplantation, replantation. This model provides unique opportunity to visualize important events that occur during reperfusion like capillary perfusion, leukocyte-endothelial interaction, microvasculature response and endothelial permeability. It is a potent model for intravital investigation of muscle microcirculation subjected to IRI.

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Abbreviations

EIA:

External iliac artery

EIV:

External iliac vein

FA:

Femoral artery

FCD:

Functional capillary density

FV:

Femoral vein

IL:

Inguinal ligament

IRI:

Ischemia reperfusion injury

MPI:

Microvascular permeability index

PPV:

Preselected postcapillary venule

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Author information

Authors and Affiliations

  1. Department of Vascular Surgery, Eskulap Hospital, Osielsko, Poland

    Michal Molski MD, PhD

  2. Department of Plastic Reconstructive and Aesthetic Surgery, Istanbul Bilim University Faculty Of Medicine - Sisli Florence Nightingale Hospital, Istanbul, Turkey

    Ilker Yazici MD

  3. Department of Orthopaedics, University of Illinois at Chicago, Chicago, IL, USA

    Maria Z. Siemionow MD, PhD, DSc

Authors
  1. Michal Molski MD, PhD
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  2. Ilker Yazici MD
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  3. Maria Z. Siemionow MD, PhD, DSc
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Editor information

Editors and Affiliations

  1. Department of Orthopaedics, University of Illinois at Chicago, Chicago, Illinois, USA

    Maria Z. Siemionow

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© 2015 Springer-Verlag London

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Molski, M., Yazici, I., Siemionow, M.Z. (2015). Standard Cremaster Muscle Model for Ischemia Reperfusion. In: Siemionow, M. (eds) Plastic and Reconstructive Surgery. Springer, London. https://doi.org/10.1007/978-1-4471-6335-0_9

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  • DOI: https://doi.org/10.1007/978-1-4471-6335-0_9

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  • Publisher Name: Springer, London

  • Print ISBN: 978-1-4471-6334-3

  • Online ISBN: 978-1-4471-6335-0

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