Skip to main content
SpringerLink
Log in

Full Face Transplant Model in Rats

  • Chapter
  • First Online:
Plastic and Reconstructive Surgery

  • 2114 Accesses

Abstract

In this chapter authors present composite full face transplantation model in rats based on the bilateral common carotid arteries and external jugular veins. It is the first rodent model of full face transplantation which introduced to literature in 2003 by Ulusal et al. Along with its surgical details as an new composite tissue transplantation, developers also confirmed the feasibility of full face allograft transplantation across MHC barriers in the rodent model for the first time in the literature. Transplants were performed between semi-allogeneic LBN donors and Lewis recipients and long term survival without sings of rejection was achieved up to 200 days under low dose cyclosporine A monotherapy.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
eBook
USD 16.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 119.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Ulusal BG, Ulusal AE, Ozmen S, Zins JE, Siemionow MZ. A new composite facial and scalp transplantation model in rats. Plast Reconstr Surg. 2003;112:1302–11.

    Article  PubMed  Google Scholar 

  2. Siemionow M, Gozel-Ulusal B, Engin Ulusal A, Ozmen S, Izycki D, Zins JE. Functional tolerance following face transplantation in the rat. Transplantation. 2003;75:1607–9.

    Article  PubMed  Google Scholar 

  3. Kulahci Y, Bayram Y, Karagoz H, Sever C, Sahin C. Experimental Craniofacial Composite Tissue Allotransplantation (CCTA) models in rats. Arch Clin Exp Surg. 2012;1:181–7.

    Google Scholar 

  4. Agaoglu G, Kulahci Y, Siemionow M. Face transplantation: past, present and future. [Yüz transplantasyonu: dünü bugünü ve yarını]. Turk Plast Surg. 2006;14:8–13 [Article in Turkish].

    Google Scholar 

  5. Siemionow M, Kulahci Y. Experimental approaches to composite tissue allograft transplants. In: Lanzetta M, Dubernard JM, editors. Hand transplantation. Milan: Springer; 2007. p. 61–77.

    Chapter  Google Scholar 

  6. Siemionow M, Kulahci Y. In preparation for facial transplantation. In: Eisenmann-Klein M, Neuhann-Lorens C, editors. Innovations in plastic and reconstructive surgery. Berlin: Springer; 2008. p. 150–9.

    Google Scholar 

  7. Yazici I, Carnevale K, Klimczak A, Siemionow M. A new rat model of maxilla allotransplantation. Ann Plast Surg. 2007;58:338–44.

    Article  CAS  PubMed  Google Scholar 

  8. Yazici I, Unal S, Siemionow M. Composite hemiface/calvaria transplantation model in rats. Plast Reconstr Surg. 2006;118:1321–7.

    Article  CAS  PubMed  Google Scholar 

  9. Kulahci Y, Klimczak A, Siemionow M. Long term survival of composite hemiface/mandible/tongue tissue allograft permitted by donor specific chimerism. Plast Reconstr Surg. 2006;118(4 Suppl):34–5.

    Article  Google Scholar 

  10. Siemionow M, Kulahci Y. Facial transplantation. Semin Plast Surg. 2007;21:259–68.

    Article  PubMed Central  PubMed  Google Scholar 

  11. Siemionow M, Bozkurt M, Kulahci Y. Current status of composite tissue allotransplantation. Handchir Mikrochir Plast Chir. 2007;39:145–55.

    Article  CAS  PubMed  Google Scholar 

  12. Siemionow M, Kulahci Y. Experimental models of composite tissue allograft transplants. Sem Plast Surg. 2007;21:205–12.

    Article  Google Scholar 

  13. Siemionow MZ, Kulahci Y, Bozkurt M. Composite tissue allotransplantation. Plast Reconstr Surg. 2009;124(6 Suppl):e327–39.

    Article  CAS  PubMed  Google Scholar 

  14. Altuntas SH, Zor F, Siemionow M. Total osteocutaneous hemiface allotransplantation model in rats. Plast Reconstr Surg. 2010;6S:117.

    Article  Google Scholar 

  15. Kulahci Y, Siemionow M. A new composite hemiface/mandible/tongue transplantation model in rats. Ann Plast Surg. 2010;64:114–21.

    Article  CAS  PubMed  Google Scholar 

  16. Kulahci Y, Klimczak A, Madajka M, Altuntas S, Siemionow M. Long-term survival of composite hemiface/mandible/tongue allografts correlates with multilineage chimerism development in the lymphoid and myeloid compartments of recipients. Transplantation. 2010;90:843–52.

    Article  CAS  PubMed  Google Scholar 

  17. Unal S, Agaoglu G, Zins J, Siemionow M. New surgical approach in facial transplantation extends survival of allograft recipients. Ann Plast Surg. 2005;55:297–303.

    Article  CAS  PubMed  Google Scholar 

  18. Eduardo Bermudez Dez L, Santamaria A, Romero T, et al. Experimental model of facial transplant. Plast Reconstr Surg. 2002;110:1374–5.

    Article  Google Scholar 

  19. Demir Y, Ozmen S, Klimczak A, Mukherjee AL, Siemionow M. Tolerance induction in composite facial allograft transplantation in the rat model. Plast Reconstr Surg. 2004;114:1790–801.

    Article  PubMed  Google Scholar 

  20. Siemionow MZ, Demir Y, Sari A, Klimczak A. Facial tissue allograft transplantation. Transplant Proc. 2005;37:201–4.

    Article  CAS  PubMed  Google Scholar 

  21. Siemionow M, Demir Y, Mukherjee A, Klimczak A. Development and maintenance of donor-specific chimerism in semi-allogenic and fully major histocompatibility complex mismatched facial allograft transplants. Transplantation. 2005;79:558–67.

    Article  CAS  PubMed  Google Scholar 

  22. Zor F, Bozkurt M, Nair D, Siemionow M. A new composite midface allotransplantation model with sensory and motor reinnervation. Transpl Int. 2010;23:649–56.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Hand and Upper Extremity Surgery, Gulhane Military Medical Academy, Ankara, Turkey

    Yalcin Kulahci MD

  2. Department of Orthopaedics, University of Illinois at Chicago, Chicago, IL, USA

    Maria Z. Siemionow MD, PhD, DSc

Authors
  1. Yalcin Kulahci MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Maria Z. Siemionow MD, PhD, DSc
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Yalcin Kulahci MD .

Editor information

Editors and Affiliations

  1. Department of Orthopaedics, University of Illinois at Chicago, Chicago, Illinois, USA

    Maria Z. Siemionow

Rights and permissions

Reprints and permissions

Copyright information

© 2015 Springer-Verlag London

About this chapter

Cite this chapter

Kulahci, Y., Siemionow, M.Z. (2015). Full Face Transplant Model in Rats. In: Siemionow, M. (eds) Plastic and Reconstructive Surgery. Springer, London. https://doi.org/10.1007/978-1-4471-6335-0_34

Download citation

  • DOI: https://doi.org/10.1007/978-1-4471-6335-0_34

  • Published:

  • Publisher Name: Springer, London

  • Print ISBN: 978-1-4471-6334-3

  • Online ISBN: 978-1-4471-6335-0

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation