Abstract
Providing donor specific tolerance and avowing the adverse effects of systemic immunosuppression is the ultimate aim of vascularized composite allotransplantation. Various methods have been used to promote immunotolerance and most accepted methods are based on cellular therapies such as bone marrow transplantation. As an immunologic organ, thymus transplantation is also described to enable recipient T cells to develop and mature within the donor thymus and to provide donor-specific transplantation tolerance. However, there is no model of both vascularized bone marrow transplantation and thymus transplantation. This chapter describes a composite osseomusculocutaneous sternum, ribs, thymus, pectoralis muscles and skin allotransplanatation model of bone marrow transplantation model.
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Bozkurt, M., Zor, F. (2015). Composite Osseomusculocutaneous Thymus Allotransplantation Model. In: Siemionow, M. (eds) Plastic and Reconstructive Surgery. Springer, London. https://doi.org/10.1007/978-1-4471-6335-0_30
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DOI: https://doi.org/10.1007/978-1-4471-6335-0_30
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