Skip to main content

Vascular Thymus Transplantation Model

  • Chapter
  • First Online:
Plastic and Reconstructive Surgery
  • 2091 Accesses

Abstract

Thymus is a specialized organ of the immune system, responsible for the maturation, differention, and education of T lymphocytes. While nonvascular implantation of thymic tissues may cause ischemia and disruption of the normal microarchitecture of the gland, vascular transplantation gives no harm to the microarchitecture. A new method of thymus transplantation is introduced, in which the graft is directly connected with the recipient’s vascular system which might be used both in euthymic rats and congenitally athymic nude rats. This novel model is a unique vascular transplantation to evaluate the viability of vascularized thymus transplantation, immunotransplantation, and maturation of the T cells.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 89.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 119.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Fukuzaki T, Hancock WW, Monaco AP, Maki T. Indefinite survival of skin allografts in adult thymectomized, antilymphocyte serum-treated mice given bone marrow and thymus grafts of donor origin: tolerance induction by donor bone marrow and thymus. Transplantation. 1998;65(04):1036.

    Article  CAS  PubMed  Google Scholar 

  2. Foster RD, Fan L, Niepp M, Foster RD, Fan L, Niepp M, Kaufman C, McCalmont T, Ascher N, et al. Donor-specific tolerance induction in composite tissue allografts. Am J Surg. 1998;176:418–21.

    Article  CAS  PubMed  Google Scholar 

  3. Sherburne CG, Onyekaba CO, Condie RM. Induction of immune unresponsiveness by intrathymic injection of allogeneic cells in a murine model. Transplant Proc. 1993;25:30.

    Google Scholar 

  4. Hong R, Moore AL. A method is presented for organ culture of postnatal thymus. Transplantation. 1996;61:444.

    Article  CAS  PubMed  Google Scholar 

  5. Atkinson K, Parr M, Stewart P, Thomas ED, Storb R, Ochs HD, et al. Thymus transplantation after allogeneic bone marrow graft to prevent chronic graft-versus-host disease in humans. Transplantation. 1982;33(2):168–73.

    Article  CAS  PubMed  Google Scholar 

  6. Markert ML, Ward FE, Rice HE, Schiff SE, Buckley RH, Haynes BF, et al. Transplantation of thymus tissue in complete DiGeorge syndrome. N Engl J Med. 1999;341(16):1180–9.

    Article  CAS  PubMed  Google Scholar 

  7. Tasuchia M, Shimabukora K, Mizuno Y. Adult human autoimmune thymus transplantation into nude mice – functioning of human thymus epithelium in nude mice. Biochem Exp Biol. 1978;14:101.

    Google Scholar 

  8. Kampinga J, Schuil A, Pol GH, et al. Vascular thymus transplantation in rats. Technique, morphology, and function. Transplantation. 1990;50:669.

    Article  CAS  PubMed  Google Scholar 

  9. Kampinga J, Schuil A, Pol GH, et al. Transplant Proc. 1986;18:1429.

    Google Scholar 

  10. Zhao D, Wang L, Na N, Huang Z, Miao B, Hong L. A model of isolated, vascular whole thymus transplantation in nude rats. Transplant Proc. 2012;44(5):1394–8.

    Article  CAS  PubMed  Google Scholar 

  11. Jiang J, Wang H, Madrens J, Zhong R. Surgical technique for vascularized thymus transplantation in mice. Microsurgery. 1999;19(2):56–60.

    Article  CAS  PubMed  Google Scholar 

  12. Ortak T, Oke R, Unsal M, Carnevale K, Siemionow M. A model of vascular thymus transplantation in athymic rats. Transplant Proc. 2001;33:372–4.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Turgut Ortak MD .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2015 Springer-Verlag London

About this chapter

Cite this chapter

Ortak, T. (2015). Vascular Thymus Transplantation Model. In: Siemionow, M. (eds) Plastic and Reconstructive Surgery. Springer, London. https://doi.org/10.1007/978-1-4471-6335-0_24

Download citation

  • DOI: https://doi.org/10.1007/978-1-4471-6335-0_24

  • Published:

  • Publisher Name: Springer, London

  • Print ISBN: 978-1-4471-6334-3

  • Online ISBN: 978-1-4471-6335-0

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics