Abstract
The immunology of composite tissue allotransplantation is complex because the grafts are composed of a variety of tissues, such as skin, fat, muscle, nerves, lymph nodes, bone, cartilage, ligaments, and bone marrow, representing different antigenicities. Composite tissue allotransplantation transplants are not routinely performed today because of the need for lifelong nonspecific immunosuppressive agents to prevent the immune system from rejecting the foreign tissue. Researchers have been actively looking for alternative methods that can induce lifelong tolerance using less toxic regimens. One such method could be tolerance, chimeric rat model by transplanting both thymus and hind limb of the one specie rat as donor to the other specie rat as recipient.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Gordon CR, Nazzal J, Lozano-Calderan SA, Lee SG, Lee WP, Siemionow M, et al. From experimental rat hindlimb to clinical face composite tissue allotransplantation: historical background and current status. Microsurgery. 2006;26:566–72. doi:10.1002/micr.20296.
Gorantla V, Maldonado C, Frank J, Barker JH. Composite tissue allotransplantation (CTA): current status and future insights. Eur J Trauma. 2001;27:267–74.
Siemionow M, Ozer K. Advances in composite tissue allograft transplantation as related to the hand and upper extremity. J Hand Surg Am. 2002;27:565–80. doi:10.1053/jhsu.2002.34367.
Siemionow M, Papay F, Kulahci Y, Djohan R, Hammert W, Hendrickson M, et al. Coronal-posterior approach for face/scalp flap harvesting in preparation for face transplantation. J Reconstr Microsurg. 2006;22:399–405. doi:10.1055/s-2006-947693.
Siemionow M, Bozkurt M, Kulahci Y. Current status of composite tissue allotransplantation. Handchir Mikrochir Plast Chir. 2007;39:145–55.
Lee WP, Yaremchuk MJ, Pan YC, Randolph MA, Tan CM, Weiland AJ. Relative antigenicity of components of a vascularized limb allograft. Plast Reconstr Surg. 1991;87:401–11.
Foster RD, Fan L, Neipp M, Kaufman C, McCalmont T, Ascher N, et al. Donor specific tolerance induction in composite tissue allografts. Am J Surg. 1998;176(5):418–21.
Gammie JS, Li S, Colson YL, Demetris AJ, Neipp M, Ildstad ST, Pham SM. A partial conditioning strategy for achieving mixed chimerism in rat: tacrolimus and anti-lymphocyte serum substantially reduce the minimum radiation dose for engraftment. Exp Hematol. 1998;26(10):927–35.
Gyopar AF, Loertscher R, Guttman RD, Tchervenkov JI. A comparison among the effects of donor-specific whole blood, bone marrow, and spleen leukocytes on allograft survival when combined with cyclosporine. Transplantation. 1993;55(5):1199–202.
Hewitt CW, Llull R, Patel MP, et al. Mechanisms of unresponsiveness associated with pretransplant blood transfusion-cyclosporine-induced mixed lymphocyte chimerism. Transpl Int. 1994;7:559.
Adanali G, Ozer K, Siemionow M. Early and late effects of ischemic preconditioning on microcirculation of skeletal muscle flaps. Plast Reconstr Surg. 2002;109(4):1344–51.
Küntscher MV, Kastell T, Sauerbier M, Nobiling R, Gebhard MM, Germann G. Acute remote ischemic preconditioning on a rat cremasteric muscle flap model. Microsurgery. 2002;22(6):221–6. doi:10.1002/micr.10041.
Siemionow M, Klimczak A. Chimerism-based experimental models for tolerance induction in vascularized composite allografts: Cleveland Clinic Research Experience Clinical and Developmental Immunology 2013; Article ID 831410, 12 pages.
Siemionow M, Izycki D, Ozer K, Ozmen S, Klimczak A. Role of thymus in operational tolerance induction in limb allograft transplant model. Transplantation. 2006;81(11):1568–76. doi:10.1097/01.tp.0000209508.37345.82.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2015 Springer-Verlag London
About this chapter
Cite this chapter
Ortak, T. (2015). Vascular Thymus and Hind Limb Allotransplantation Model. In: Siemionow, M. (eds) Plastic and Reconstructive Surgery. Springer, London. https://doi.org/10.1007/978-1-4471-6335-0_23
Download citation
DOI: https://doi.org/10.1007/978-1-4471-6335-0_23
Published:
Publisher Name: Springer, London
Print ISBN: 978-1-4471-6334-3
Online ISBN: 978-1-4471-6335-0
eBook Packages: MedicineMedicine (R0)