Vascular Thymus and Hind Limb Allotransplantation Model
The immunology of composite tissue allotransplantation is complex because the grafts are composed of a variety of tissues, such as skin, fat, muscle, nerves, lymph nodes, bone, cartilage, ligaments, and bone marrow, representing different antigenicities. Composite tissue allotransplantation transplants are not routinely performed today because of the need for lifelong nonspecific immunosuppressive agents to prevent the immune system from rejecting the foreign tissue. Researchers have been actively looking for alternative methods that can induce lifelong tolerance using less toxic regimens. One such method could be tolerance, chimeric rat model by transplanting both thymus and hind limb of the one specie rat as donor to the other specie rat as recipient.
KeywordsComposite tissue allotransplantation Vascular Thymus Transplantation Chimerism Chimeric rat model Allotransplantation
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