Abstract
Immediately following its description in 1978, the orthotopic hind limb transplantation in rats became the most commonly used animal model to study acute and chronic rejection in vascularized composite tissue allografts. Although the general principles of hind limb transplantation did not change over time, various authors have modified the original technique in attempt to reduce complication rates (including nonunion, malunion, intraoperative bleeding, postoperative infection), and shorten the operative time. Individual components of the hind limb were also used alone or in combination to test the host’s immune response to various components of the VCA.
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Ozer, K. (2015). Rat Hind Limb and Cremaster Allograft Transplantation Model. In: Siemionow, M. (eds) Plastic and Reconstructive Surgery. Springer, London. https://doi.org/10.1007/978-1-4471-6335-0_20
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DOI: https://doi.org/10.1007/978-1-4471-6335-0_20
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