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Neuroimmune Effects of Developmental TCE Exposure

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Trichloroethylene: Toxicity and Health Risks

Part of the book series: Molecular and Integrative Toxicology ((MOLECUL))

Abstract

Exposure to certain chemical, biological or physiological risk factors prior to adulthood can alter developmental processes and may in some instances enhance disease risk. This chapter will concentrate on the known effects of exposure to trichloroethylene (TCE) during gestation, lactation, and/or early life on the brain and immune system and discuss how this persistent environmental pollutant may impede immunologic and neurologic development to promote developmental pathology. Possible neuroimmune mechanisms and therapeutic interventions to circumvent the neurotoxic and adverse neurobehavioral effects of developmental TCE exposure are proposed.

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Authors and Affiliations

  1. Department of Pediatrics, University of Arkansas for Medical Sciences, College of Medicine, Arkansas Children’s Hospital Research Institute, 13 Children’s Way, Little Rock, AR, 72202, USA

    Sarah J. Blossom PhD

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  1. Sarah J. Blossom PhD
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Correspondence to Sarah J. Blossom PhD .

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Editors and Affiliations

  1. Department of Microbiology and Immunology, Arkansas Children’s Hospital Research Institute, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA

    Kathleen M. Gilbert

  2. Department of Pediatrics, Arkansas Children’s Hospital Research Institute, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA

    Sarah J. Blossom

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Blossom, S.J. (2014). Neuroimmune Effects of Developmental TCE Exposure. In: Gilbert, K., Blossom, S. (eds) Trichloroethylene: Toxicity and Health Risks. Molecular and Integrative Toxicology. Springer, London. https://doi.org/10.1007/978-1-4471-6311-4_7

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