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Model-Based Systems Engineering: Extracorporeal Membrane Oxygenation (ECMO) Therapy

  • Nathan L. Adams
  • L. Drew Pihera
  • Stephen P. Blalock
  • Matthew L. Paden
Chapter
Part of the Simulation Foundations, Methods and Applications book series (SFMA)

Abstract

ECMO therapy is used to treat patients with severe cardiac and/or respiratory failure and has been shown to improve patient survival rates.ECMO was introduced in the 1970’s and is now used in more than 230 medical centers worldwide.Despite the widespread use of ECMO therapy, the technology has not been subjected to the rigorous development cycle needed to improve system performance and correlate system architectures to patient outcomes.For example, the lack of formal standards for the arrangement of components that make up the ECMO circuit have resulted in a large number of unique ECMO solutions with unknown differential effectiveness.In addition, best practices for operation and maintenance, or training and certification of ECMO specialists are areas of the ECMO domain that have not been explored.Collaboration between systems engineering (SE) and medical professionals leverages SE principles to understand and solve ECMO technological and safety challenges.In the following case study, the SE approach is used to evaluate a children’s hospital’s ECMO system using model based systems engineering (MBSE) to capture the ECMO domain, concept of operations, need statement, high level use cases, requirements, system and user behaviors, and both abstract and physical structural designs.The system model is then used to enable the development of an ECMO Data Collaboration Tool (EDCT) concept that will one day allow the medical community to document ECMO circuits for best-of-breed analyses.

Keywords

Circuit Design Extracorporeal Membrane Oxygenation Blood Pump Part Property Circuit Architecture 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. Adams NL, Pihera LD (2013) A systems engineering based approach for informing extracorporeal membrane oxygenation (ECMO) therapy improvements. Paper presented at the Conference on Systems Engineering Research, Atlanta, 19–22 March, 2013Google Scholar
  2. ECMO Policy and Procedure Manual (2011) ECMO and advanced technology department. Childrens Healthcare of Atlanta at Egleston. Atlanta, GA, 2011Google Scholar
  3. Extracorporeal Life Support International Summary (2010) Extracorporeal life support organization. http://www.elso.med.umich.edu. Accessed October 2011
  4. Friedenthal S, Moore A, Steiner R (2009) A practical guide to SysML. Kaufmann, New YorkGoogle Scholar
  5. Van Meurs K, Lally KP, Peek G, Zwischenberger JB (eds) (2005) ECMO extracorporeal cardiopulmonary support in critical care, 3rd ed. ECMO, Ann ArborGoogle Scholar

Copyright information

© Springer-Verlag London 2015

Authors and Affiliations

  • Nathan L. Adams
    • 1
  • L. Drew Pihera
    • 1
  • Stephen P. Blalock
    • 2
  • Matthew L. Paden
    • 3
  1. 1.Georgia Tech Research InstituteAtlantaUSA
  2. 2.MI TechnologiesSuwaneeUSA
  3. 3.Childrens Healthcare of AtlantaAtlantaUSA

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