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Toxic Trauma pp 165–174Cite as

The Longer-Term Consequences of Toxic Trauma

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Abstract

The period up to 24 h following the emergency management of acute toxic exposure is of critical importance in the prevention and recognition of developing pathology with a longer latency. The nervous system may develop a re-paralysis following the depolarising paralysis of the acute cholinergic system. This re-paralysis is a non-depolarising block, known as intermediate syndrome and may indicate a conformational change in the acetylcholine receptors in the neuromuscular junction leading to a failure of transmission and subsequent muscle paralysis. After a week following exposure to organophosphate (OP) pesticides, the peripheral nervous system may also develop OP-induced delayed neuropathy (OIPDN). In the lungs, toxic pulmonary oedema may develop after 12–24 h following exposure to lung-damaging agents. Resting a patient at risk, using steroids and applying appropriate protective artificial ventilation measures may modify the onset of pulmonary oedema and possibly acute respiratory distress syndrome.

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Authors and Affiliations

  1. Hôpital Necker—Enfants Malades, SAMU de Paris, 149 rue de sèvres, 75043, Paris, CEDEX 15, France

    Dr. David J. Baker

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  1. Dr. David J. Baker
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Correspondence to David J. Baker .

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Baker, D. (2014). The Longer-Term Consequences of Toxic Trauma. In: Toxic Trauma. Springer, London. https://doi.org/10.1007/978-1-4471-5598-0_9

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