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Tissue Typing, Crossmatch and Antibody Incompatibility in Kidney Transplantation

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Practical Nephrology

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Abstract

For the majority of suitable patients with end-stage renal disease (ESRD), transplantation offers a significant survival advantage, improved quality of life and a substantial saving in terms of annual medical care. In countries with limited or no chronic dialysis provision, transplantation may offer the only hope of survival for patients with ESRD. However in every country with a transplant programme, the demand for kidney transplants continues to outstrip supply with the consequence that many patients fail to be transplanted in a timely fashion or at all. The two principal immunological barriers to solid organ transplantation (SOT); blood group incompatibility and HLA incompatibility have restricted access to transplantation. In the last two decades, strategies to expand the pool of donors have become increasingly commonplace and include the use of blood group-incompatible (ABOi) transplants, HLA-incompatible transplants (HLAi), acceptable mismatch schemes and paired-exchange programmes.

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Author information

Authors and Affiliations

  1. UCL Centre for Nephrology and the Anthony Nolan Trust, Hospital Royal Free London NHS Foundation Trust, Rowland Hill Street, London, NW3 2PF, UK

    Henry Stephens BSc, PhD

  2. UCL Centre for Nephrology, Royal Free Hospital, Pond Street, London, NW3 2QG, UK

    Peter J. Dupont PhD, FRCPI

  3. UCL Department of Nephrology, Royal Free London NHS Foundation Trust, Pond Street, Hampstead, London, NW3 2QG, UK

    Mark Harber MBBS, PhD, FRCP

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  1. Henry Stephens BSc, PhD
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  2. Peter J. Dupont PhD, FRCPI
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  3. Mark Harber MBBS, PhD, FRCP
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Correspondence to Henry Stephens BSc, PhD .

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Editors and Affiliations

  1. UCL Department of Nephrology, Royal Free London NHS Foundation Trust, London, United Kingdom

    Mark Harber

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Stephens, H., Dupont, P.J., Harber, M. (2014). Tissue Typing, Crossmatch and Antibody Incompatibility in Kidney Transplantation. In: Harber, M. (eds) Practical Nephrology. Springer, London. https://doi.org/10.1007/978-1-4471-5547-8_67

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  • DOI: https://doi.org/10.1007/978-1-4471-5547-8_67

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  • Print ISBN: 978-1-4471-5546-1

  • Online ISBN: 978-1-4471-5547-8

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