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Changing the Paradigm to Understand and Manage Atrial Fibrillation

  • Gheorghe-Andrei DanEmail author
Chapter
Part of the Current Cardiovascular Therapy book series (CCT)

Abstract

Atrial Fibrillation (AF) is a very prevalent disease with increasing incidence with important consequences on outcome and quality of life. Despite improvement in our knowledge about the mechanisms involved in the initiation and perpetuation of AF the therapy is still challenging. The current statement of the clinical equivalence between rate control and rhythm control strategy is biased by the efficacy and safety limitations of the current antiarrhythmic drugs and by treating AF as an exclusively homogenous electrical disease. A better understanding of the complex mechanisms for AF initiation and perpetuation helps to change the management paradigm and to understand better the targets of the future therapy aimed to restore and maintain the sinus rhythm with the expected long-term consequences on outcome.

Keywords

Atrial Fibrillation Action Potential Duration Persistent Atrial Fibrillation Electrical Remodel Maintain Sinus Rhythm 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Abbreviations

AAD

Antiarrhythmic drug therapy

AF

Atrial fibrillation

APD

Action potential duration

CHF

Congestive heart failure

EF

Ejection fraction

HR

Heart rate

HX

History

QOL

Quality of life

RCT

Randomized controlled trials

SR

Sinus rhythm

TGFβ1

Tumor Growth Factor β1

TIA

Transient ischemic attack

WL

Wavelength

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Copyright information

© Springer-Verlag London 2014

Authors and Affiliations

  1. 1.University of Medicine “Carol Davila”BucharestRomania
  2. 2.Internal Medicine Clinic, Cardiology DepartmentColentina University HospitalBucharestRomania

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