The Healing of Segmental Bone Defects, Induced by Recombinant Human Bone Morphogenetic Protein (rhBMP-2): A Radiographic, Histological, and Biomechanical Study in Rats



Yasko AW, Lane JM, Fellinger EJ, Rosen V, Wozney JM, Wang A


Bone Formation Bone Morphogenetic Protein Osteogenic Differentiation Segmental Defect Endochondral Ossification 
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  1. 1.
    Urist MR. Bone: formation by autoinduction. Science. 1965;150(3698):893–9.PubMedCrossRefGoogle Scholar
  2. 2.
    Urist MR, DeLange RJ, Finerman GA. Bone cell differentiation and growth factors. Science. 1983;220(4598):680–6.PubMedCrossRefGoogle Scholar
  3. 3.
    Azad V, Breitbart E, Al-Zube L, Yeh S, O’Connor JP, Lin SS. rhBMP-2 enhances the bone healing response in a diabetic rat segmental defect model. J Orthop Trauma. 2009;23(4):267–76.PubMedCrossRefGoogle Scholar
  4. 4.
    Dinopoulos H, Giannoudis PV. (iv) The use of bone morphogenetic proteins (BMPs) in long-bone non-unions. Curr Orthop. 2007;21(4):268–79.CrossRefGoogle Scholar
  5. 5.
    Lane JM. Bone morphogenic protein science and studies. J Orthop Trauma. 2005;19(10):S17–22.PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag London 2014

Authors and Affiliations

  1. 1.Departmet of Orthopaedics and TraumaRoyal Liverpool University HospitalLiverpoolUK

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