Skip to main content

Genitourinary Tract in Women with Marfan Syndrome

  • Chapter
  • First Online:
Book cover Diagnosis and Management of Marfan Syndrome

Abstract

Pelvic organ prolapse and urinary stress incontinence in women are multifactorial in etiology. The etiologic factors associated with these two conditions are thought to have considerable overlap. Stress incontinence is associated with hypermobility of the bladder neck as well as intrinsic sphincter weakness with most patients having overlap of these two components. Hypermobility of the bladder neck can be elicited on physical examination with the presence of cystourethrocele.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 99.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 129.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 179.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Al-Rawi ZS, Al Rawa ZT. Joint hypermobility in women with genital prolapse. Lancet. 1982;1(8287):1439–41.

    Article  CAS  PubMed  Google Scholar 

  2. Norton PA, Baker JE, Sharp HC, Warenski JC. Genitourinary prolapse and joint hypermobility in women. Obstet Gynecol. 1995;85:225–8.

    Article  CAS  PubMed  Google Scholar 

  3. McIntosh LJ, Mallett VT, Frahm JK, Richardson DA, Evans MI. Gynecologic disorders in women with Ehlers-Danlos syndrome. J Soc Gynecol Investig. 1995;2(3):559–64.

    Article  CAS  PubMed  Google Scholar 

  4. McIntosh LJ, Stanitski DF, Mallett VT, Frahm JD, Richardson DA, Evans MI. Ehlers-Danlos syndrome: relationship between joint hypermobility, urinary incontinence and pelvic floor prolapse. Gynecol Obstet Invest. 1996;41(2):135–9.

    Article  CAS  PubMed  Google Scholar 

  5. Sayer TR, Dixon JS, Hosker GL, Warrell DW. A study of paraurethral connective tissue in women with stress incontinence of urine. Neurourol Urodynam. 1990;9:319–20.

    Article  Google Scholar 

  6. Falconer C, Ekman G, Malmstrom A, Ulmsten U. Decreased collagen synthesis in stress incontinent women. Obstet Gynecol. 1994;84:583–6.

    CAS  PubMed  Google Scholar 

  7. Jackson SR, Avery NC, Tarilton JF, Eckford SK, Abrams P, Bailey AJ. Changes in metabolism of collagen in genitourinary prolapse. Lancet. 1996;347:1658–61.

    Article  CAS  PubMed  Google Scholar 

  8. Keane DP, Sims TJ, Abrams P, Bailey AJ. Analysis of collagen status in premenopausal nulliparous women with genuine stress incontinence. Br J Obstet Gynaecol. 1997;104:994–8.

    Article  CAS  PubMed  Google Scholar 

  9. Marfan MA. Un cas de deformation congenitale des quatre membres, plus prononcee aux extremities, caracterisee par l’allongement des os avec un certain degre d’eminicissement. Bull Mem Soc Med Hos Paris. 1896;13:220–6.

    Google Scholar 

  10. Beighton P, de Paepe A, Danks K, Finidori G, Gedde-Dahl T, Goodman R, et al. International nosology of heritable disorders of connective tissue. Am J Med Genet. 1988;53:46–54.

    Google Scholar 

  11. Dietz HC, Pyeritz RE. Mutations in human gene for fibrillin-1 (FBN-1) in Marfan syndrome and related disorders. Hum Mol Genet. 1995;4:1799–809.

    CAS  PubMed  Google Scholar 

  12. Strohbehn K, Jakary JA, Delancey JOL. Pelvic organ prolapse in young women. Obstet Gynecol. 1997;90:33–6.

    Article  CAS  PubMed  Google Scholar 

  13. Jackson S, Donavan J, Brookes S, Eckford S, Swithinbank L, Abrams P. The Bristol female lower urinary tract symptoms questionnaire: development and psychometric testing. Br J Urol. 1996;77:805–12.

    Article  CAS  PubMed  Google Scholar 

  14. Beighton PH, Solomon L, Soskolne CL. Articular mobility in an African population. Ann Rheum Dis. 1973;32:413–8.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. Hempel C, Wienhold D, Denker N, Eggersmann C, Thuroff JW. Definition of overactive bladder and epidemiology of urinary incontinence. Urology. 1997;50(Suppl 6A):4–14.

    Article  Google Scholar 

  16. Bump RC, Mattiasson A, Bo K, Brubaker LP, DeLancey JOL, Klarskov P, et al. The standardization of terminology of female pelvic organ prolapse and pelvic floor dysfunction. Am J Obstet Gynecol. 1996;175:10–7.

    Article  CAS  PubMed  Google Scholar 

  17. Olsen AL, Smith VJ, Bergstrom JO, Colling JC, Clark AL. Epidemiology of surgically managed pelvic organ prolapse and urinary incontinence. Obstet Gynecol. 1997;89:501–6.

    Article  CAS  PubMed  Google Scholar 

  18. Samuelsson EC, Victor FTA, Tibblin G, Svardsudd KF. Signs of genital prolapse in a Swedish population of women 20 to 59 years of age and possible related factors. Am J Obstet Gynecol. 1999;180:299–305.

    Article  CAS  PubMed  Google Scholar 

  19. Black NA, Downs SH. The effectiveness of surgery for stress incontinence in women: a systematic review. Br J Urol. 1996;78:497–510.

    Article  CAS  PubMed  Google Scholar 

  20. Leach GE, Dmochowski RR, Appell RA, Blaivas JG, Hadley HR, Luber KM, et al. Female stress urinary incontinence clinical guidelines panel summary report on surgical management of female stress urinary incontinence. J Urol. 1997;158:875–80.

    Article  CAS  PubMed  Google Scholar 

  21. McLaren M, Bridges AB, Gray JR, Tamei H, Belch JJF. Endothelial cell and platelet function in Marfan syndrome. Endothelium. 1993;1:203–7.

    Article  Google Scholar 

  22. Silverman DI, Burton KJ, Gray J, Bosner MS, Kouchoukos NT, Roman MJ, Boxer M, Devereux RB, Tsipouras P. Life expectancy in the Marfan syndrome. Am J Cardiol. 1995;75(2):157–60.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Anne H. Child MD, FRCP .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2016 Springer-Verlag London

About this chapter

Cite this chapter

Jabs, C., Child, A.H. (2016). Genitourinary Tract in Women with Marfan Syndrome. In: Child, A. (eds) Diagnosis and Management of Marfan Syndrome. Springer, London. https://doi.org/10.1007/978-1-4471-5442-6_20

Download citation

  • DOI: https://doi.org/10.1007/978-1-4471-5442-6_20

  • Published:

  • Publisher Name: Springer, London

  • Print ISBN: 978-1-4471-5441-9

  • Online ISBN: 978-1-4471-5442-6

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics