Renal Cell and Renal Pelvis/Ureter Carcinoma
Renal Cell and Renal Pelvis/Ureter Carcinoma: this chapter outlines the incidence, risk factors, clinical presentation, investigations, treatments and prognosis of cancer at this anatomical site. These features are correlated with the core data that are required to make the corresponding histopathology reports of a consistently high quality, available in an appropriate timeframe, and clinically relevant to patient management and prognosis. Summary details of the common cancers given at this site include: gross description, histological types, tumour grade/differentiation, extent of local tumour spread, lymphovascular invasion, lymph node involvement, and the status of excision margins. Current WHO Classifications of Malignant Tumours and TNM7 are referenced. Notes are provided on other associated pathology, contemporary use of immunohistochemistry, updates on the role of evolving molecular tests, and the use of these ancillary techniques as biomarkers in diagnosis, and prediction of prognosis and treatment response. A summary is given of the commoner non-carcinoma malignancies that are encountered at this site in diagnostic practice.
KeywordsFoam Adenoma Sarcoma Oxalate Renin
- Algaba F, Delahunt B, Berney DM, Camparo P, Comperat E, Griffiths D, Kristiansen G, Lopez-Beltran A, Martignoni G, Moch H, Montironi R, Varma M, Egevad L. Handling and reporting of nephrectomy specimens for adult renal tumours: a survey by the European network of uropathology. J Clin Pathol. 2012;65:106–13.PubMedCrossRefGoogle Scholar
- Allen DC. Histopathology reporting: guidelines for surgical cancer. 2nd ed. Springer: London; 2006.Google Scholar
- Bostwick DG, Cheng L. Urologic surgical pathology. 2nd ed. St. Louis: Mosby/Elsevier; 2008.Google Scholar
- D’ Agati VD, Jennette JC, Silva FG. Non-neoplastic kidney diseases, Atlas of nontumor pathology. Washington: AFIP; 2005.Google Scholar
- Eble JN, Sauter G, Epstein JI, Sesterhenn IA. WHO classification of tumours. Pathology and genetics. Tumours of the urinary system and male genital organs. Lyon: IARC Press; 2004.Google Scholar
- Murphy WM, Grignon DJ, Perlman EJ. Tumors of the kidney, bladder and related urinary structures. Atlas of tumor pathology. 4th series. Fascicle. Washington: AFIP; 2004.Google Scholar
- The Royal College of Pathologists. Cancer Datasets (Adult Renal Parenchymal Cancer, Renal Tumours in Childhood, Penile Cancer, Prostatic Carcinoma, Testicular Tumours and Post-Chemotherapy Residual Masses, Tumours of the Urinary Collecting System) and Tissue Pathways (Medical Renal Biopsies, Urological Pathology). Accessed at http://www.rcpath.org/index.asp?PageID=254.