Abstract
Gestational Trophoblastic Tumours: this chapter outlines the incidence, risk factors, clinical presentation, investigations, treatments and prognosis of cancer at this anatomical site. These features are correlated with the core data that are required to make the corresponding histopathology reports of a consistently high quality, available in an appropriate timeframe, and clinically relevant to patient management and prognosis. Summary details of the common cancers given at this site include: gross description, histological types, tumour grade/differentiation, extent of local tumour spread, lymphovascular invasion, lymph node involvement, and the status of excision margins. Current WHO Classifications of Malignant Tumours and TNM7 are referenced. Notes are provided on other associated pathology, contemporary use of immunohistochemistry, updates on the role of evolving molecular tests, and the use of these ancillary techniques as biomarkers in diagnosis, and prediction of prognosis and treatment response. A summary is given of the commoner non-carcinoma malignancies that are encountered at this site in diagnostic practice.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Bibliography
Baergen N. Manual of pathology of the human placenta. 2nd ed. New York: Springer; 2011.
Fox H, Sebire N. Pathology of the placenta, Major problems in pathology series, vol. 7. 3rd ed. Philadelphia: Saunders; 2007.
Fox H, Wells M, editors. Haines and Taylor. Obstetrical and gynaecological pathology. 5th ed. Edinburgh: Churchill Livingstone; 2003.
Kaplan CG. Color atlas of gross placental pathology. 2nd ed. New York: Springer; 2006.
Lage JM. Protocol for the examination of specimens from patients with gestational trophoblastic malignancies. Arch Pathol Lab Med. 1999;123:50–4.
Lage JM, Minamiguchi S, Richardson MS. Gestational trophoblastic diseases: update on new immunohistochemical findings. Curr Diagn Pathol. 2003;9:1–10.
Paradinas FJ. The histological diagnosis of hydatidiform moles. Curr Diagn Pathol. 1994;1:24–31.
Paradinas FJ. The differential diagnosis of choriocarcinoma and placental site tumour. Curr Diagn Pathol. 1998;5:93–101.
Robboy SJ, Bentley RC, Russell R, Anderson MC, Mutter GL, Prat J. Pathology of the female reproductive tract. 2nd ed. London: Churchill Livingstone Elsevier; 2009.
Sebire NJ, Rees H. Diagnosis of gestational trophoblastic disease in early pregnancy. Curr Diagn Pathol. 2002;8:430–40.
Sebire NJ, Rees HC, Peston D, Seckl MJ, Newlands ES, Fisher RA. P57 KIP2 immunohistochemical staining of gestational trophoblastic tumours does not identify the type of the causative pregnancy. Histopathology. 2004;45:135–41.
Silverberg SG, Kurman RJ. Tumors of the uterine corpus and gestational trophoblastic disease. Atlas of tumor pathology. 3rd series. Fascicle 3. Washington: AFIP; 1992.
The Royal College of Pathologists. Tissue Pathway for histopathological examination of the placenta. Accessed at http://www.rcpath.org/index.asp?PageID=1675.
Author information
Authors and Affiliations
Rights and permissions
Copyright information
© 2013 Springer-Verlag London
About this chapter
Cite this chapter
Allen, D.C. (2013). Gestational Trophoblastic Tumours. In: Histopathology Reporting. Springer, London. https://doi.org/10.1007/978-1-4471-5263-7_28
Download citation
DOI: https://doi.org/10.1007/978-1-4471-5263-7_28
Published:
Publisher Name: Springer, London
Print ISBN: 978-1-4471-5262-0
Online ISBN: 978-1-4471-5263-7
eBook Packages: MedicineMedicine (R0)