Lung Carcinoma: this chapter outlines the incidence, risk factors, clinical presentation, investigations, treatments and prognosis of cancer at this anatomical site. These features are correlated with the core data that are required to make the corresponding histopathology reports of a consistently high quality, available in an appropriate timeframe, and clinically relevant to patient management and prognosis. Summary details of the common cancers given at this site include: gross description, histological types, tumour grade/differentiation, extent of local tumour spread, lymphovascular invasion, lymph node involvement, and the status of excision margins. Current WHO Classifications of Malignant Tumours and TNM7 are referenced. Notes are provided on other associated pathology, contemporary use of immunohistochemistry, updates on the role of evolving molecular tests, and the use of these ancillary techniques as biomarkers in diagnosis, and prediction of prognosis and treatment response. A summary is given of the commoner non-carcinoma malignancies that are encountered at this site in diagnostic practice.
KeywordsLymphoma Adenocarcinoma Sarcoma Bevacizumab Cavitation
- Association of Directors of Anatomic and Surgical Pathology. Recommendations for the reporting of resected primary lung carcinoma. Hum Pathol. 1995;26:937–9.Google Scholar
- Baldwin DR, White B, Schmidt-Hansen M, Champion AR, Melder AM on behalf of the Guideline Development Group. Diagnosis and treatment of lung cancer: summary of updated NICE guidance. BMJ. 2011;343:1019–22.Google Scholar
- Colby TV, Koss MN. Tumors of the lower respiratory tract. Atlas of tumor pathology. 3rd series. Fascicle 13. Washington: AFIP; 1995.Google Scholar
- Corrin B, Nicholson AG. Pathology of the lungs. 3rd ed. London: Churchill Livingstone; 2011.Google Scholar
- McNulty M, Cox G, Au-Yong I. Investigating the solitary pulmonary nodule. BMJ. 2012;344:44–6.Google Scholar
- The Royal College of Pathologists. Lung Cancer Dataset and Tissue Pathways for Pulmonary Pathology and Cardiovascular Pathology. Accessed at http://www.rcpath.org/index.asp?PageID=254.
- Travis WD, Colby TV, Koss MN, Rosado-de-Christenson ML, Muller NL, King TE. Non-neoplastic disorders of the respiratory tract. Atlas of nontumor pathology. Fascicle 2. Washington: AFIP; 2002.Google Scholar
- Travis WD, Brambilla E, Muller-Hermelink HK, Harris CC. WHO classification of tumours, Pathology and genetics. Tumours of the lung, pleura, thymus and heart. Lyon: IARC Press; 2004.Google Scholar