Oesophageal Carcinoma: this chapter outlines the incidence, risk factors, clinical presentation, investigations, treatments and prognosis of cancer at this anatomical site. These features are correlated with the core data that are required to make the corresponding histopathology reports of a consistently high quality, available in an appropriate timeframe, and clinically relevant to patient management and prognosis. Summary details of the common cancers given at this site include: gross description, histological types, tumour grade/differentiation, extent of local tumour spread, lymphovascular invasion, lymph node involvement, and the status of excision margins. Current WHO Classifications of Malignant Tumours and TNM7 are referenced. Notes are provided on other associated pathology, contemporary use of immunohistochemistry, updates on the role of evolving molecular tests, and the use of these ancillary techniques as biomarkers in diagnosis, and prediction of prognosis and treatment response. A summary is given of the commoner non-carcinoma malignancies that are encountered at this site in diagnostic practice.
KeywordsObesity Formalin Lymphoma Adenocarcinoma Acidity
- Allen DC. Histopathology reporting: guidelines for surgical cancer. 2nd ed. London: Springer; 2006.Google Scholar
- Allum WH, Blazeby JM, Griffin SM, Cunningham D, Jankowski JA, Wong R, On behalf of the Association of Upper Gastrointestinal Surgeons of Great Britain and Northern Ireland, the British Society of Gastroenterology and the British Association of Surgical Oncology. Guidelines for the management of oesophageal and gastric cancer. Gut. 2011;60:1449–72.PubMedCrossRefGoogle Scholar
- Bosman FT, Carneiro F. WHO classification of tumours of the digestive system. 4th ed. Lyon: IARC press; 2010.Google Scholar
- Cotton P, Williams C. Practical gastrointestinal endoscopy. 4th ed. London: Blackwell Science; 1996.Google Scholar
- Galmiche JP, Pallone F. Barrett’s oesophagus and oesophageal adenocarcinoma. Gut. 2005;54(S1):i1–42.Google Scholar
- Lewin KJ, Appelman HD. Tumors of the esophagus and stomach. Atlas of tumor pathology. 3rd series. Fascicle 18. Washington: AFIP; 1996.Google Scholar
- Logan RPH, Harris A, Misciewicz JJ, Baron JH, editors. ABC of the upper gastrointestinal tract. London: BMJ Books; 2002.Google Scholar
- Odze RD, Goldblum JR. Surgical pathology of the GI tract, liver, biliary tract and pancreas. 2nd ed. Philadelphia: Saunders Elsevier; 2009.Google Scholar
- The Royal College of Pathologists: Cancer Datasets (Oesophageal Carcinoma, Gastric Carcinoma, Carcinomas of the Pancreas, ampulla of Vater and Common Bile Duct, Colorectal Cancer, Gastrointestinal Stromal Tumours (GISTs), Liver Resection Specimens and Liver Biopsies for Primary and Metastatic Carcinoma, Endocrine Tumours of the Gastrointestinal Tract including Pancreas) and Tissue Pathways (Gastrointestinal and Pancreatobiliary Pathology, Liver Biopsies for the Investigation of Medical Disease and for Focal Liver Lesions). Accessed at http://www.rcpath.org/index.asp?PageID=254.