Abstract
Coronary blood flow is responsible for providing nutrients and oxygen to the heart thus enabling it to pump blood to itself and the rest of the circulatory system. Given this important task, oxygen supply must be matched very closely to the demands of the myocardium. This is accomplished through various regulatory mechanisms that can have deleterious effects if interrupted due to the presence of coronary stenosis or other factors that affect basal and hyperemic blood flow. As such, knowledge of these mechanisms is imperative in understanding the physiological assessment of coronary stenosis and in treating various cardiac conditions.
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References
Hoffman JI, Spaan JA. Pressure-flow relations in coronary circulation. Physiol Rev. 1990;70:331–90.
Mann DL, Zipes DP, Libby P, Bonow RO, Braunwald E. Braunwald’s heart disease: a textbook of cardiovascular medicine. 10th ed. Philadelphia: Elsevier Saunders; 2014.
National Heart, Lung, and Blood Institute: Atherosclerosis. 2014. http://www.nhlbi.nih.gov/health/health-topics/topics/cad. Accessed 13 Dec 2014.
Stouffer GA, Wiley Online Library (Online Service). Cardiovascular hemodynamics for the clinician. Malden: Blackwell Futura; 2008.
Pappano AJ, Wier WG, Levy MN. Cardiovascular physiology. 10th ed. Philadelphia: Elsevier/Mosby; 2013.
Gould KL, Lipscomb K. Effects of coronary stenoses on coronary flow reserve and resistance. Am J Cardiol. 1974;34:48–55.
Sato A, Terata K, Miura H, et al. Mechanism of vasodilation to adenosine in coronary arterioles from patients with heart disease. Am J Physiol Heart Circ Physiol. 2005;288:H1633–40.
Deussen A, Ohanyan V, Jannasch A, Yin L, Chilian W. Mechanisms of metabolic coronary flow regulation. J Mol Cell Cardiol. 2012;52:794–801.
Wexels JC, Myhre ES, Mjos OD. Effects of carbon dioxide and pH on myocardial blood-flow and metabolism in the dog. Clin Physiol (Oxford Engl). 1985;5:575–88.
Vanhoutte PM. Vascular biology. Old-timer makes a comeback. Nature. 1998;396(213):5–6.
Luksha L, Agewall S, Kublickiene K. Endothelium-derived hyperpolarizing factor in vascular physiology and cardiovascular disease. Atherosclerosis. 2009;202:330–44.
Busse R, Forstermann U, Matsuda H, Pohl U. The role of prostaglandins in the endothelium-mediated vasodilatory response to hypoxia. Pflugers Arch Eur J Physiol. 1984;401:77–83.
Kalsner S. The effect of hypoxia on prostaglandin output and on tone in isolated coronary arteries. Can J Physiol Pharmacol. 1977;55:882–7.
Dai XZ, Bache RJ. Effect of indomethacin on coronary blood flow during graded treadmill exercise in the dog. Am J Physiol. 1984;247:H452–8.
Rezkalla SH, Kloner RA. Cocaine-induced acute myocardial infarction. Clin Med Res. 2007;5:172–6.
Wang CH, Kuo LT, Hung MJ, Cherng WJ. Coronary vasospasm as a possible cause of elevated cardiac troponin I in patients with acute coronary syndrome and insignificant coronary artery disease. Am Heart J. 2002;144:275–81.
MacAlpin RN. Cardiac arrest and sudden unexpected death in variant angina: complications of coronary spasm that can occur in the absence of severe organic coronary stenosis. Am Heart J. 1993;125:1011–7.
Zaya M, Mehta PK, Merz CN. Provocative testing for coronary reactivity and spasm. J Am Coll Cardiol. 2014;63:103–9.
Takagi Y, Yasuda S, Takahashi J, et al. Clinical implications of provocation tests for coronary artery spasm: safety, arrhythmic complications, and prognostic impact: multicentre registry study of the Japanese Coronary Spasm Association. Eur Heart J. 2013;34:258–67.
Pepine CJ. Ergonovine echocardiography for coronary spasm: facts and wishful thinking. J Am Coll Cardiol. 1996;27:1162–3.
Camici PG, Olivotto I, Rimoldi OE. The coronary circulation and blood flow in left ventricular hypertrophy. J Mol Cell Cardiol. 2012;52:857–64.
Kern MJ, Lerman A, Bech JW, et al. Physiological assessment of coronary artery disease in the cardiac catheterization laboratory: a scientific statement from the American Heart Association Committee on Diagnostic and Interventional Cardiac Catheterization, Council on Clinical Cardiology. Circulation. 2006;114:1321–41.
Kern MJ, Samady H. Current concepts of integrated coronary physiology in the catheterization laboratory. J Am Coll Cardiol. 2010;55:173–85.
Tonino PA, De Bruyne B, Pijls NH, et al. Fractional flow reserve versus angiography for guiding percutaneous coronary intervention. N Engl J Med. 2009;360:213–24.
McCormack JG, Halestrap AP, Denton RM. Role of calcium ions in regulation of mammalian intramitochondrial metabolism. Physiol Rev. 1990;70(2):391–425.
Berne RM, Sperelakis N. The cardiovascular system. Bethesda: American Physiological Society; 1979.
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Cami, E. (2015). Physiology of Coronary Blood Flow. In: Abbas, A. (eds) Interventional Cardiology Imaging. Springer, London. https://doi.org/10.1007/978-1-4471-5239-2_2
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DOI: https://doi.org/10.1007/978-1-4471-5239-2_2
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