Abstract
Arterial stiffening, especially of the large elastic arteries, is a fundamental vascular aging trait, which is, however, accelerated in the presence of genetic and environmental factors. It is an early marker of subclinical arterial disease but also a well-established biomarker of clinical cardiovascular disease events and cardiovascular disease mortality. Preventive strategies calcium channel blockade and allopurinol, a careful individualized de-stiffening strategy on the basis of sodium balance, in combination with the renin–angiotensin system blockade, appears to be the currently available optimal strategy.
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Protogerou, A.D., Safar, M.E., Plante, G.E., Blacher, J. (2014). De-stiffening Strategy, Sodium Balance, and Blockade of the Renin–Angiotensin System. In: Safar, M., O'Rourke, M., Frohlich, E. (eds) Blood Pressure and Arterial Wall Mechanics in Cardiovascular Diseases. Springer, London. https://doi.org/10.1007/978-1-4471-5198-2_43
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