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Decreasing Arterial Stiffness and/or Wave Reflections Independently of Mean Arterial Pressure: Effect of Non-antihypertensive Drugs (Part 2)

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Blood Pressure and Arterial Wall Mechanics in Cardiovascular Diseases

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Abstract

Change in arterial stiffness with drugs is a major endpoint in clinical trials, although evidence for arterial stiffness as a therapeutic target still needs to be confirmed. Although antihypertensive drugs have been the most studied (as developed in Chap. 39), other drug classes have also been assessed, including hormone replacement therapy, lipid-lowering drugs, some antidiabetic agents, and anti-inflammatory drugs. For these drugs which do not directly affect blood pressure, the mechanism by necessity includes direct effect on the arterial wall and the extracellular matrix. We also present some recent evidence of completely different pathways such as interaction with the lamin A pathway which have demonstrated true “destiffening” properties.

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Authors and Affiliations

  1. Clinical Research Unit and Pharmacy, Fondation Hôpital Saint Joseph, Paris, France

    Héléne Beaussier

  2. Hopital Europeen Georges Pompidou, Assistance Publique Hôpitaux de Paris, Université Paris Descartes, Paris, France

    Héléne Beaussier

  3. Department of Pharmacology and Institut National de la Santé et de la Recherche Médicale U970(Eq7)-PARCC, Hôpital Européen Georges Pompidou, Assistance Publique-Hôpitaux de Paris, Université Paris-Descartes, 20, rue Leblanc, 75015, Paris, France

    Stéphane Laurent & Pierre Boutouyrie

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  1. Héléne Beaussier
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  2. Stéphane Laurent
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  3. Pierre Boutouyrie
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Correspondence to Pierre Boutouyrie .

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Editors and Affiliations

  1. Hôtel-Dieu Hospital Diagnosis and Therapeutics Center, Paris Descartes University, Paris, Paris, France

    Michel E. Safar

  2. St Vincent Clinic and Hospital, University of New South Wales, Victor Chang Cardiac Research Institute, Darlinghurst, Sydney, New South Wales, Australia

    Michael F. O'Rourke

  3. Department of Cardiology, Ochsner Clinic Foundation, New Orleans, Louisiana, USA

    Edward D. Frohlich

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Beaussier, H., Laurent, S., Boutouyrie, P. (2014). Decreasing Arterial Stiffness and/or Wave Reflections Independently of Mean Arterial Pressure: Effect of Non-antihypertensive Drugs (Part 2). In: Safar, M., O'Rourke, M., Frohlich, E. (eds) Blood Pressure and Arterial Wall Mechanics in Cardiovascular Diseases. Springer, London. https://doi.org/10.1007/978-1-4471-5198-2_40

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  • DOI: https://doi.org/10.1007/978-1-4471-5198-2_40

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