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Heart Failure with Preserved Ejection Fraction

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Blood Pressure and Arterial Wall Mechanics in Cardiovascular Diseases

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Abstract

Of the millions of heart failure heart failure patients worldwide, approximately half present with preserved left ventricular ejection fraction (HFPEF). HFPEF has high rates of morbidity and mortality, yet therapy remains empirical due to incomplete understanding of disease pathophysiology. Systemic hypertension is the most prominent risk factor for HFPEF. Patients often have multiple other comorbid conditions, which may contribute to symptom burden and the HFPEF syndrome itself. The classic paradigm of ventricular diastolic dysfunction has expanded, and vascular dysfunction likely contributes to HFPEF in many patients. Pressure-volume loop analysis identifies three distinct hemodynamic phenotypes for HFPEF, a finding which may have significant implications for clinical trial enrollment and individual patient treatment.

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  1. Division of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA

    Scott L. Hummel

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  1. Hôtel-Dieu Hospital Diagnosis and Therapeutics Center, Paris Descartes University, Paris, Paris, France

    Michel E. Safar

  2. St Vincent Clinic and Hospital, University of New South Wales, Victor Chang Cardiac Research Institute, Darlinghurst, Sydney, New South Wales, Australia

    Michael F. O'Rourke

  3. Department of Cardiology, Ochsner Clinic Foundation, New Orleans, Louisiana, USA

    Edward D. Frohlich

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Hummel, S.L. (2014). Heart Failure with Preserved Ejection Fraction. In: Safar, M., O'Rourke, M., Frohlich, E. (eds) Blood Pressure and Arterial Wall Mechanics in Cardiovascular Diseases. Springer, London. https://doi.org/10.1007/978-1-4471-5198-2_16

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