Abstract
Intra-arterial chemoembolization allows the administration of embolic agents and/or drugs to treat arterialized liver tumors, thus reducing the systemic side effects and sparing the disease-free liver parenchyma. Various techniques can be performed: transarterial embolization (TAE), transarterial chemo-infusion (TACI) with a high concentration of chemotherapy agents and minimal embolization, transarterial chemoembolization (TACE), and chemoembolization with drug-eluting beads (DEB TACE). Irradiation techniques are also therapeutic alternatives such as radioembolization with yttrium 90 and injection of radioactive Lipiodol (I 131): these highly specialized techniques are at the crossroads of interventional radiology, nuclear medicine, and radiotherapy, thus will not be developed in this chapter.
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Suggested Reading
Basile A, Carrafiello G, Ierardi AM, Tsetis D, Brountzos E. Quality-improvement guidelines for hepatic transarterial chemoembolization. Cardiovasc Intervent Radiol. 2012;35:765–74.
Bruix J, Sherman M. Management of hepatocellular carcinoma: an update – AASLD practice guidelines. Hepatology. 2010;53:1–34.
Cleveland TJ, Kelekis AD, Kopp C, et al. CIRSE take force on clinical pratice: Hepato Cellular Carinoma. In: Clinical practice in interventional radiology CIRSE, Vienna 2007. p. 74–9.
Liapi E, Geschwind JF. Intra-arterial therapies for hepatocellular carcinoma: where do we stand? Ann Surg Oncol. 2010;17:1234–46.
Liapi E, Geschwind JF. Transcatheter arterial chemo embolization for liver cancer: is it time to distinguish conventional from drug eluting chemoembolization? Cardiovasc Intervent Radiol. 2011;34:37–49.
Llovet JM. Updated treatment approach to hepatocellular carcinoma. J Gastroenterol. 2005;40(3):225–35.
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Chabrot, P., Lankoande, A.A., Dumousset, E., Abergel, A., Pezet, D., Boyer, L. (2014). Chemoembolizations and Hepatic Intra-arterial Chemotherapies. In: Chabrot, P., Boyer, L. (eds) Embolization. Springer, London. https://doi.org/10.1007/978-1-4471-5182-1_7
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DOI: https://doi.org/10.1007/978-1-4471-5182-1_7
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