Abstract
Epidemiological data implicate obstructive sleep apnea as an independent contributor to the occurrence of stroke. One of the potential patho-physiological links implicates paradoxical embolism in patients with patent foramen ovale. This chapter discusses the hemodynamics of obstructive sleep apnea relevant to the patients with patent foramen ovale, and their connection to the theory of paradoxical embolism.
Conflicts of Interest
TK and GSR report no conflicts of interest. VKS has served as a consultant for Respicardia, Neu Pro, and Res Med, and works with Mayo Health Solutions and their industry partners on intellectual property related to sleep and cardiovascular disease. Mayo Foundation has received a gift from the Phillips-Respironics Foundation for the study of sleep apnea and cardiovascular disease.
Sources of Funding
Mayo Foundation; National Institutes of Health (R01 HL065176); Grants from European Regional Development Fund (CZ.1.05/1.1.00/02.0123).
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Abbreviations
- OSA:
-
Obstructive sleep apnea
- PFO:
-
Patent foramen ovale
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Konecny, T., Reeder, G.S., Somers, V.K. (2015). Obstructive Sleep Apnea and Patent Foramen Ovale. In: Amin, Z., Tobis, J., Sievert, H., Carroll, J. (eds) Patent Foramen Ovale. Springer, London. https://doi.org/10.1007/978-1-4471-4987-3_14
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DOI: https://doi.org/10.1007/978-1-4471-4987-3_14
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