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Novel Predictors of Sudden Cardiac Death

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Electrical Diseases of the Heart

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Abstract

Despite recent advances in resuscitation science, survival from sudden cardiac arrest (SCA) remains low, and sudden cardiac death (SCD) remains a public health problem of significant proportions. In the United States, estimates of the annual incidence of SCD range from 250,000 to 300,000. Currently, severe left ventricular (LV) dysfunction measured by the LV ejection fraction is the best available predictor of SCD risk and the major indication for primary prevention with the implantable cardioverter-defibrillator (ICD). However, there are major inadequacies associated with using LV ejection fraction for prediction of risk and there is a significant scope for enhancement of risk stratification. This chapter will discuss the utility and limitations of severe LV systolic dysfunction as a risk predictor of SCD, other predictors in the process of being evaluated and finally, the promise that new genomic predictors may also contribute to the process of SCD risk stratification.

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Authors and Affiliations

  1. The Heart Institute, Cedars-Sinai Medical Center, 8700 Beverly Blvd, Saperstein 2S48, Los Angeles, CA, 90048, USA

    Sumeet S. Chugh MD

  2. Cedars-Sinai Heart Institute, 8700 Beverly Blvd. Davis, Suite 1059, Los Angeles, 1059, CA, USA

    Rasmus Havmöller MD, PhD, Carmen Teodorescu MD, PhD, Adriana Huertas-Vazquez PhD, Audrey Uy-Evanado MD & Kyndaron Reinier PhD, MPH

  3. Department of Cardiology, Karolinska University Hospital, Odengatan 37, 11351, Stockholm, Sweden

    Rasmus Havmöller MD, PhD

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  1. Sumeet S. Chugh MD
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  2. Rasmus Havmöller MD, PhD
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  3. Carmen Teodorescu MD, PhD
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  4. Adriana Huertas-Vazquez PhD
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  5. Audrey Uy-Evanado MD
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  6. Kyndaron Reinier PhD, MPH
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Correspondence to Sumeet S. Chugh MD .

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  1. , Department of Internal Medicine, UMDNJ-RWJ Medical School, Robert Wood Johnson Pl. 1, New Brunswick, 08903-0019, New Jersey, USA

    Ihor Gussak

  2. , Gordon K. Moe Scholar, Masonic Medical Research Laboratory, Bleecker Street, Utica, 13501-1787, New York, USA

    Charles Antzelevitch

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Chugh, S.S., Havmöller, R., Teodorescu, C., Huertas-Vazquez, A., Uy-Evanado, A., Reinier, K. (2013). Novel Predictors of Sudden Cardiac Death. In: Gussak, I., Antzelevitch, C. (eds) Electrical Diseases of the Heart. Springer, London. https://doi.org/10.1007/978-1-4471-4978-1_19

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