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Abstract

Submucous fibroids present one of the most challenging pathologies in reproductive surgery. Concomitant use of 2D/3D US and hysteroscopy provides the most efficient and fast information for the size, localization and penetrance of the submucous myoma in relation to the endometrial cavity and myometrium. MRI provides the highest accuracy and reproducibility concerning fibroids, however, due its cost is used only for difficult and complicated cases. Small fibroids upto 1.5 cm can be operated by mechanical hysteroscopy, however in larger ones bipolar resectoscopy is preferable. Preoperative GnRHa are indicated for myomas >4 cm for 1–2 months, in order to reduce myoma volume and ease surgery, treat menorrhagia, thin the endometrium and elevate Hb. New technological advances such as hysteroscopic morcelators and shavers with automatic chip aspiration seem to be efficient, safe and faster, however large and RCTs are not still available.

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References

  1. Bettocchi S, Achilarre MT, Ceci O, Luigi S. Fertility-enhancing hysteroscopic surgery. Semin Reprod Med. 2011;29(2):75–82.

    Article  PubMed  Google Scholar 

  2. Pritts EA, Parker WH, Olive DL. Fibroids and infertility: an updated systematic review of the evidence. Fertil Steril. 2009;91:1215–23.

    Article  PubMed  Google Scholar 

  3. Szamatowicz J, Laudanski T, Bulkszas B, Akerlund A. Fibromas and uterine contractions. Acta Obstet Gynecol Scand. 1997;76:973–6.

    Article  CAS  PubMed  Google Scholar 

  4. Yoshino O, Nishii O, Osuga Y, Asada H, Okuda S, Orisaka M, Hori M, Fujiwara T, Hayashi T. Myomectomy decreases abnormal uterine peristalsis and increases pregnancy rate. J Minim Invasive Gynecol. 2012;19:63–7.

    Article  PubMed  Google Scholar 

  5. Rackow BW, Taylor HS. Submucosal uterine leiomyomas have a global effect on molecular determinants of endometrial receptivity. Fertil Steril. 2010;93(6):2027–34.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  6. Taylor E, Gomel V. The uterus and fertility. Fertil Steril. 2008;89(1):1–16.

    Article  PubMed  Google Scholar 

  7. Gianaroli L, Gordts S, D’Angelo A, Magli MC, Brosens I, Cetera C, Campo R, Ferraretti AP. Effect of inner myometrium fibroid on reproductive outcome after IVF. Reprod Biomed Online. 2005;10:473–7.

    Article  PubMed  Google Scholar 

  8. Surrey ES, Minjarez DA, Stevens JM, Schoolcraft WB. Effect of myomectomy on the outcome of assisted reproductive technologies. Fertil Steril. 2005;83:1473–9.

    Article  PubMed  Google Scholar 

  9. Jun SH, Ginsburg ES, Racowsky C, Wise LA, Hornstein MD. Uterine leiomyomas and their effect on in vitro fertilization outcome: a retrospective study. J Assist Reprod Genet. 2001;18(3):139–43.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  10. Yoshino O, Hayashi T, Osuga Y, Orisaka M, Asada H, Okuda S, Hori M, Furuya M, Onuki H, Sadoshima Y, Hiroi H, Fujiwara T, Kotsuji F, Yoshimura Y, Nishii O, Taketani Y. Decreased pregnancy rate is linked to abnormal uterine peristalsis caused by intramural fibroids. Hum Reprod. 2010;25(10):2475–9.

    Article  CAS  PubMed  Google Scholar 

  11. Dueholm M, Lundorf E, Hansen ES, Ledertoug S, Olesen F. Accuracy of magnetic resonance imaging and transvaginal ultrasonography in the diagnosis, mapping, and measurement of uterine myomas. Am J Obstet Gynecol. 2002;186:409–15.

    Article  PubMed  Google Scholar 

  12. Wamsteker K, Emanuel MH, de Kruif JH. Trancervical hysteroscopic resection of submucous fibroids for abnormal uterine bleeding: results regarding the degree of intramural extension. Obstet Gynecol. 1993;82(5):736–40.

    CAS  PubMed  Google Scholar 

  13. Lasmar RB, Barrozo PRM, Dias R, Oiveira MAP. Submucous myomas: a new presurgical classification to evaluate the viability of hysteroscopic surgical treatment.-preliminary report. J Minim Invasive Gynecol. 2005;12:308–11.

    Article  PubMed  Google Scholar 

  14. Muzii L, Boni T, Bellati F, Marana R, Ruggiero A, Zullo MA, Angioli R, Panici PB. GnRH analogue treatment before hysteroscopic resection of submucous myomas: a prospective, randomized, multicenter study. Fertil Steril. 2010;94(4):1496–9.

    Article  CAS  PubMed  Google Scholar 

  15. Gurates B, Parmaksiz C, Kilic G, Celik H, Kumru S, Simsek M. Treatment of symptomatic uterine leiomyoma with letrozole. Reprod Biomed Online. 2008;17(4):569–74.

    Article  CAS  PubMed  Google Scholar 

  16. Levy BS. Modern management of uterine fibroids. Acta Obstet Gynecol Scand. 2008;87(8):812–23.

    Article  PubMed  Google Scholar 

  17. Fedele L, Vercellini P, Bianchi S, Brioschi D, Dorta M. Treatment with GnRH agonists before myomectomy and the risk of short-term fibroid recurrence. Br J Obstet Gynaecol. 1990;97:393–6.

    Article  CAS  PubMed  Google Scholar 

  18. Bradley LD. Complications in hysteroscopy: prevention, treatment and legal risk. Curr Opin Obstet Gynecol. 2002;14:409–15.

    Article  PubMed  Google Scholar 

  19. Lin B, Akiba Y, Iwata Y. One-step hysteroscopic removal of sinking submucous fibroid in two infertile patients. Fertil Steril. 2000;74:1035–8.

    Article  CAS  PubMed  Google Scholar 

  20. Thurkow AL, Admiraal CF, Emanuel MH, Van Kesteren PJM, Veersema S. Submucous myomas: diagnosis and therapy. Gynaecol Surg. 2008;5:93–102.

    Article  Google Scholar 

  21. Bettocchi S, Siristatidis C, Pontrelli G, et al. The destiny of myomas: should we treat small submucous myomas in women of reproductive age? Fertil Steril. 2008;90(4):905–10.

    Article  PubMed  Google Scholar 

  22. Shokeir T, El-shafie M, Yousef H, Allam A, Sadek E. Submucous myomas and their implications in the pregnancy rates of patients with otherwise unexplained primary infertility undergoing hysteroscopic myomectomy: a randomized matched control study. Fertil Steril. 2009;92:S44–S4.

    Article  Google Scholar 

  23. Donnez J, Polet R, Smets M, Bassil S, Nisolle M. Hysteroscopic myomectomy. Curr Opin Obstet Gynecol. 1995;7:311–6.

    Article  CAS  PubMed  Google Scholar 

  24. Darwish A. Modified hysteroscopic myomectomy of large submucous fibroids. Gynecol Obstet Invest. 2003;56(4):192–6. Epub 2003 Oct 23.

    Article  PubMed  Google Scholar 

  25. Hamou J. Electroresection of fibroids. In: Sutton C, Diamond MP, editors. Endoscopic surgery for gynecologists. London: WB Saunders; 1993. p. 327–30.

    Google Scholar 

  26. Murakami T, Tachibana M, Hoshiai T, Ozawa Y, Terada Y, Okamura K. Successful strategy for the hysteroscopic myomectomy of a submucous fibroid arising from the uterine fundus. Fertil Steril. 2006;86:1513.e19–22.

    Google Scholar 

  27. Indman PD. Use of carboprost to facilitate hysteroscopic resection of submucous fibroids. J Am Assoc Gynecol Laparosc. 2004;11:68–72.

    Article  PubMed  Google Scholar 

  28. Hallez JP. Single-stage total hysteroscopic myomectomies: indications, techniques, and results. Fertil Steril. 1995;63:703–8.

    CAS  PubMed  Google Scholar 

  29. Hallez JP. Myomectomies by endo-uterine resection. Curr Opin Obstet Gynecol. 1996;8:250–6.

    Article  CAS  PubMed  Google Scholar 

  30. Garuti G, Luerti M. Hysteroscopic bipolar surgery: a valuable progress or a technique under investigation? Curr Opin Obstet Gynecol. 2009;21(4):329–34.

    Article  PubMed  Google Scholar 

  31. Emanuel MH, Wamsteker K. The intra uterine morcellator: a new hysteroscopic operating technique to remove intrauterine polyps and fibroids. J Minim Invasive Gynecol. 2005;12:62–6.

    Article  PubMed  Google Scholar 

  32. Gallinat A. The master resectoscope. J Minim Invasive Gynecol. 2005;12:S31–2.

    Article  Google Scholar 

  33. Bigatti G, Ferrario C, Rosales M, Baglioni A, Bianchi S. IBS® Integrated Bigatti Shaver versus conventional bipolar resectoscopy: a randomised comparative study. Gynecol Surg. 2011;9:63–72.

    Article  Google Scholar 

  34. Glasser MH. Endometrial ablation and hysteroscopic myomectomy by electrosurgical vaporization. J Am Assoc Gynecol Laparosc. 1997;4:369–74.

    Article  CAS  PubMed  Google Scholar 

  35. Loffer FD. Preliminary experience with the VersaPoint bipolar resectoscope using a vaporizing electrode in a saline distending medium. J Am Assoc Gynecol Laparosc. 2000;7:498–502.

    Article  CAS  PubMed  Google Scholar 

  36. Munoz JL, Jimenez JS, Hernandez C, Vaquero G, Perez Sagaseta C, Noguero R, Miranda P, Hernandez JM, De la Fuente P. Hysteroscopic myomectomy: our experience and review. JSLS. 2003;7:39–48.

    PubMed Central  CAS  PubMed  Google Scholar 

  37. Murakami T, Tamura M, Ozawa Y, Suzuki H, Terada Y, Okamura K. Safe techniques in surgery for hysteroscopic myomectomy. J Obstet Gynaecol Res. 2005;31:216–23.

    Article  PubMed  Google Scholar 

  38. Touboul C, Fernandez H, Deffieux X, Berry R, Frydman R, Gervaise A. Uterine synechiae after bipolar hysteroscopic resection of submucosal myomas in patients with infertility. Fertil Steril. 2009; 92(5):1690–3.

    Google Scholar 

  39. Bosteels J et al. Anti-adhesion barrier gels following operative hysteroscopy for treating female infertility: a systematic review and meta-analysis. Gynecol Surg. 2014;11:113–27.

    Google Scholar 

  40. Tanos V, Brölmann H, DeWilde RL, O’Donovan P, Campo R. Myoma morcellation and leiomyosarcoma panic J Gynecol Surg. 2015. doi:10.1007/s10397-014-0876-y 40.

    Google Scholar 

  41. Brölmann H, Tanos V, Grimbizis G, Ind I, Philips K, Van den Bosch T, Sawalhe S, Van den Haak L, Jansen FW, Pijnenborg J, Taran FA, Brucker S, Wattiez A, Campo R, O’Donovan P, De Wilde RL. On behalf of the European Society of Gynaecological Endoscopy (ESGE) steering committee on fibroid morcellation J Gynecol Surg. 2015. doi:10.1007/s10397-015-0878-4, open access at Springerlink.com.

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Correspondence to Vasilios Tanos MD, PhD .

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Tanos, V. (2015). Submucous Fibroids and Infertility. In: Metwally, M., Li, TC. (eds) Reproductive Surgery in Assisted Conception. Springer, London. https://doi.org/10.1007/978-1-4471-4953-8_9

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  • DOI: https://doi.org/10.1007/978-1-4471-4953-8_9

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