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The Impact of Endometrioma and Its Surgical Treatment on Ovarian Reserve and Reproductive Performance

  • Chapter
Reproductive Surgery in Assisted Conception

Abstract

Endometriomas, which are commonly encountered in women presenting with subfertility, usually represent a dilemma to the Reproductive Specialist. Surgery remains the only effective treatment for endometriomas larger than three cm in diameter. National and international surveys have revealed that the majority of Gynaecologists and Reproductive specialists offer surgery for endometriomas in subfertile patients before fertility treatment. This is despite evidence that endometrioma surgery does not improve success rates of IVF. Furthermore, increasing evidence suggests that surgery for endometriomas significantly damages ovarian reserve and compromises ovarian responsiveness to COH during IVF. It is therefore reasonable to recommend that endometrioma surgery before IVF should only be considered in patients with marked symptoms or with vary large endometriomas, which could interfere with oocyte retrieval.

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References

  1. Von Rokitansky C. Ueber uterusdrusen-neubuildung in uterus und ovarilsarcomen. Z Ges Aerzte Wein. 1860;37:577.

    Google Scholar 

  2. Sampson JA. Peritoneal endometriosis due to menstrual dissemination of endometrial tissue in to the peritoneal cavity. Am J Obstet Gynecol. 1927;14:422–69.

    Google Scholar 

  3. Cullen TS. The distribution of adenomyomas containing uterine mucosa. Arch Surg. 1920;1:215–83.

    Google Scholar 

  4. Al-Fozan H, Tulandi T. Left lateral predisposition of endometriosis and endometrioma. Obstet Gynecol. 2002;101:164–6.

    Google Scholar 

  5. Nisolle M, Donnez J. Peritoneal endometriosis, ovarian endometriosis, and adenomyotic nodules of the rectovaginal septum are three different entities. Fertil Steril. 1997;68:585–96.

    CAS  PubMed  Google Scholar 

  6. Nezhat F, Nezhat C, Allan CJ, Metzger DA, Sears DL. Clinical and histologic classification of endometriomas. Implications for a mechanism of pathogenesis. J Reprod Med. 1992;37:771–6.

    CAS  PubMed  Google Scholar 

  7. Meyer R. Ueber den Stand der Frage der Adenomyositis und Adenomyome in allgemeinen und insbesondere ueber Adenomyositis seroepithelialis und Adenomyometritis sarcomatosa. Zentralbl Gynaecol. 1919;43:745–50.

    Google Scholar 

  8. Muzii L, Bianchi A, Croce C, Manci N, Panici PB. Laparoscopic excision of ovarian cysts: is the stripping technique a tissue-sparing procedure? Fertil Steril. 2002;77:609–14.

    PubMed  Google Scholar 

  9. Maneschi F, Marasa L, Incandela S, Mazzarese M, Zupi E. Ovarian cortex surrounding benign neoplasms: a histologic study. Am J Obstet Gynecol. 1993;169:388–93.

    CAS  PubMed  Google Scholar 

  10. Sokalska A, Timmerman D, Testa AC, Van Holsbeke C, Lissoni AA, Leone FP, Jurkovic D, Valentin L. Diagnostic accuracy of transvaginal ultrasound examination for assigning a specific diagnosis to adnexal masses. Ultrasound Obstet Gynecol. 2009;34:462–70.

    CAS  PubMed  Google Scholar 

  11. Kinkel K, Frei KA, Balleyguier C, Chapron C. Diagnosis of endometriosis with imaging: a review. Eur Radiol. 2005;16:285–98.

    PubMed  Google Scholar 

  12. Togashi K, Nishimura K, Kimura I, Tsuda Y, Yamashita K, Shibata T, Nakano Y, Konishi J, Konishi I, Mori T. Endometrial cysts: diagnosis with MR imaging. Radiology. 1991;180:73–8.

    CAS  PubMed  Google Scholar 

  13. Royal College of Obstetricians and Gynaecologists. The investigation and management of endometriosis: Green-top Guideline No 24. London: RCOG; 2008.

    Google Scholar 

  14. Vercellini P, Vendola N, Bocciolone L, Rognoni MT, Carinelli SG, Candiani GB. Reliability of the visual diagnosis of ovarian endometriosis. Fertil Steril. 1991;56:1198–200.

    CAS  PubMed  Google Scholar 

  15. Benaglia L, Somigliana E, Vercellini P, Abbiati A, Ragni G, Fedele L. Endometriotic ovarian cysts negatively affect the rate of spontaneous ovulation. Hum Reprod. 2009;24:2183–6.

    PubMed  Google Scholar 

  16. Rock JA, Guzick DS, Sengos C, Schweditsch M, Sapp KC, Jones Jr HW. The conservative surgical treatment of endometriosis: evaluation of pregnancy success with respect to the extent of disease as categorized using contemporary classification systems. Fertil Steril. 1981;35:131–7.

    CAS  PubMed  Google Scholar 

  17. Raffi F, Amer SA. Long-term reproductive performance after surgery for ovarian endometrioma. European J Obstet & Gynecol Reprod Biol. 2013;172:80–4.

    Google Scholar 

  18. Kitajima M, Defrère S, Dolmans M-M, Colette S, Squifflet J, Van Langendonckt A, Donnez J. Endometriomas as a possible cause of reduced ovarian reserve in women with endometriosis. Fertil Steril. 2011;96:685–91.

    PubMed  Google Scholar 

  19. Schubert B, Canis M, Darcha C, Artonne C, Pouly JL, Dechelotte P, Boucher D, Grizard G. Human ovarian tissue from cortex surrounding benign cysts: a model to study ovarian tissue cryopreservation. Hum Reprod. 2005;20:1786–92.

    PubMed  Google Scholar 

  20. de Ziegler D, Borghese B, Chapron C. Endometriosis and infertility: pathophysiology and management. Lancet. 2010;376:730–8.

    PubMed  Google Scholar 

  21. Almog B, Shehata F, Sheizaf B, Tulandi T. Effect of different types of ovarian cyst on antral follicle count. Fertil Steril. 2010;94:2338–9.

    PubMed  Google Scholar 

  22. Streuli I, de Ziegler D, Gayet V, Santulli P, Bijaoui G, de Mouzon J, Chapron C. In women with endometriosis anti-Mullerian hormone levels are decreased only in those with previous endometrioma surgery. Hum Reprod. 2012;27:3294–303.

    CAS  PubMed  Google Scholar 

  23. Somigliana E, Infantino M, Benedetti F, Arnoldi M, Calanna G, Ragni G. The presence of ovarian endometriomas is associated with a reduced responsiveness to gonadotropins. Fertil Steril. 2006;86:192–6.

    CAS  PubMed  Google Scholar 

  24. Almog B, Shehata F, Sheizaf B, Tan SL, Tulandi T. Effects of ovarian endometrioma on the number of oocytes retrieved for in vitro fertilization. Fertil Steril. 2011;95:525–7.

    PubMed  Google Scholar 

  25. Gelbaya TA, Nardo LG. Evidence-based management of endometrioma. Reprod Biomed Online. 2011;23:15–24.

    PubMed  Google Scholar 

  26. Wong BC, Gillman NC, Oehninger S, Gibbons WE, Stadtmauer LA. Results of in vitro fertilization in patients with enwdometriomas: is surgical removal beneficial? Am J Obstet Gynecol. 2004;191:597–606; discussion 606–7.

    Google Scholar 

  27. Nisolle-Pochet M, Casanas-Roux F, Donnez J. Histologic study of ovarian endometriosis after hormonal therapy. Fertil Steril. 1988;49:423–6.

    CAS  PubMed  Google Scholar 

  28. Jones KD, Fan A, Sutton CJ. The ovarian endometrioma: why is it so poorly managed? Indicators from an anonymous survey. Hum Reprod. 2002;17:845–9.

    CAS  PubMed  Google Scholar 

  29. Rana N, Thomas S, Rotman C, Dmowski WP. Decrease in the size of ovarian endometriomas during ovarian suppression in stage IV endometriosis. Role of preoperative medical treatment. J Reprod Med. 1996;41:384–92.

    CAS  PubMed  Google Scholar 

  30. Farquhar C, Sutton C. The evidence for the management of endometriosis. Curr Opin Obstet Gynecol. 1998;10:321–32.

    CAS  PubMed  Google Scholar 

  31. Muzii L, Marana R, Caruana P, Mancuso S. The impact of preoperative gonadotropin-releasing hormone agonist treatment on laparoscopic excision of ovarian endometriotic cysts. Fertil Steril. 1996;65:1235–7.

    CAS  PubMed  Google Scholar 

  32. Tsujioka H, Inoue Y, Emoto M, Sadamori R, Shirota K, Hachisuga T, Kawarabayashi T. The efficacy of preoperative hormonal therapy before laparoscopic cystectomy of ovarian endometriomas. J Obstet Gynaecol Res. 2009;35:782–6.

    PubMed  Google Scholar 

  33. Jones KD, Sutton C. Patient satisfaction and changes in pain scores after ablative laparoscopic surgery for stage III-IV endometriosis and endometriotic cysts. Fertil Steril. 2003;79:1086–90.

    PubMed  Google Scholar 

  34. Heaps JM, Nieberg RK, Berek JS. Malignant neoplasms arising in endometriosis. Obstet Gynecol. 1990;75:1023–8.

    CAS  PubMed  Google Scholar 

  35. Kobayashi H, Sumimoto K, Kitanaka T, Yamada Y, Sado T, Sakata M, Yoshida S, Kawaguchi R, Kanayama S, Shigetomi H, Haruta S, Tsuji Y, Ueda S, Terao T. Ovarian endometrioma – risks factors of ovarian cancer development. Eur J Obstet Gynecol Reprod Biol. 2008;138:187–93.

    PubMed  Google Scholar 

  36. Busacca M, Marana R, Caruana P, Candiani M, Muzii L, Calia C, Bianchi S. Recurrence of ovarian endometrioma after laparoscopic excision. Am J Obstet Gynecol. 1999;180:519–23.

    CAS  PubMed  Google Scholar 

  37. Fedele L, Bianchi S, Zanconato G, Berlanda N, Raffaelli R, Fontana E. Laparoscopic excision of recurrent endometriomas: long-term outcome and comparison with primary surgery. Fertil Steril. 2006;85:694–9.

    CAS  PubMed  Google Scholar 

  38. Koga K, Takemura Y, Osuga Y, Yoshino O, Hirota Y, Hirata T, Morimoto C, Harada M, Yano T, Taketani Y. Recurrence of ovarian endometrioma after laparoscopic excision. Hum Reprod. 2006;21:2171–4.

    CAS  PubMed  Google Scholar 

  39. Chen MJ, Yang JH, Yang YS, Ho HN. Increased occurrence of tubo-ovarian abscesses in women with stage III and IV endometriosis. Fertil Steril. 2004;82:498–9.

    PubMed  Google Scholar 

  40. Yaron Y, Peyser MR, Samuel D, Amit A, Lessing JB. Infected endometriotic cysts secondary to oocyte aspiration for in-vitro fertilization. Hum Reprod. 1994;9:1759–60.

    CAS  PubMed  Google Scholar 

  41. Padilla SL. Ovarian abscess following puncture of an endometrioma during ultrasound-guided oocyte retrieval. Hum Reprod. 1993;8:1282–3.

    CAS  PubMed  Google Scholar 

  42. Younis JS, Ezra Y, Laufer N, Ohel G. Late manifestation of pelvic abscess following oocyte retrieval, for in vitro fertilization, in patients with severe endometriosis and ovarian endometriomata. J Assist Reprod Genet. 1997;14:343–6.

    PubMed Central  CAS  PubMed  Google Scholar 

  43. den Boon J, Kimmel CE, Nagel HT, van Roosmalen J. Pelvic abscess in the second half of pregnancy after oocyte retrieval for in-vitro fertilization: case report. Hum Reprod. 1999;14:2402–3.

    Google Scholar 

  44. Matsunaga Y, Fukushima K, Nozaki M, Nakanami N, Kawano Y, Shigematsu T, Satoh S, Nakano H. A case of pregnancy complicated by the development of a tubo-ovarian abscess following in vitro fertilization and embryo transfer. Am J Perinatol. 2003;20:277–82.

    PubMed  Google Scholar 

  45. Sharpe K, Karovitch AJ, Claman P, Suh KN. Transvaginal oocyte retrieval for in vitro fertilization complicated by ovarian abscess during pregnancy. Fertil Steril. 2006;86(219):e11–3.

    PubMed  Google Scholar 

  46. Benaglia L, Somigliana E, Iemmello R, Colpi E, Nicolosi AE, Ragni G. Endometrioma and oocyte retrieval-induced pelvic abscess: a clinical concern or an exceptional complication? Fertil Steril. 2008;89:1263–6.

    PubMed  Google Scholar 

  47. Gelbaya TA, Gordts S, D’Hooghe TM, Gergolet M, Nardo LG. Management of endometrioma prior to IVF: compliance with ESHRE guidelines. Reprod Biomed Online. 2010;21:325–30.

    PubMed  Google Scholar 

  48. Raffi F, Shaw RW, Amer S. National survey of the current management of endometriomas in women undergoing assisted reproductive treatment. Hum Reprod. 2012;27:2712–9.

    CAS  PubMed  Google Scholar 

  49. Bateman BG, Kolp LA, Mills S. Endoscopic versus laparotomy management of endometriomas. Fertil Steril. 1994;62:690–5.

    CAS  PubMed  Google Scholar 

  50. Crosignani PG, Vercellini P, Biffignandi F, Costantini W, Cortesi I, Imparato E. Laparoscopy versus laparotomy in conservative surgical treatment for severe endometriosis. Fertil Steril. 1996;66:706–11.

    CAS  PubMed  Google Scholar 

  51. Milingos S, Loutradis D, Kallipolitis G, Liapi A, Drakakis P, Antsaklis A, Michalas S. Comparison of laparoscopy with laparotomy for the treatment of extensive endometriosis with large endometriomata. J Gynecol Surg. 1999;15:131–6.

    Google Scholar 

  52. Reich H, McGlynn F. Treatment of ovarian endometriomas using laparoscopic surgical techniques. J Reprod Med. 1986;31:577–84.

    CAS  PubMed  Google Scholar 

  53. Sutton CJ, Ewen SP, Jacobs SA, Whitelaw NL. Laser laparoscopic surgery in the treatment of ovarian endometriomas. J Am Assoc Gynecol Laparosc. 1997;4:319–23.

    CAS  PubMed  Google Scholar 

  54. Vercellini P, Vendola N, Bocciolone L, Colombo A, Rognoni MT, Bolis G. Laparoscopic aspiration of ovarian endometriomas. Effect with postoperative gonadotropin releasing hormone agonist treatment. J Reprod Med. 1992;37:577–80.

    CAS  PubMed  Google Scholar 

  55. Donnez J, Nisolle M, Gillerot S, Anaf V, Clerckx-Braun F, Casanas-Roux F. Ovarian endometrial cysts: the role of gonadotropin-releasing hormone agonist and/or drainage. Fertil Steril. 1994;62:63–6.

    CAS  PubMed  Google Scholar 

  56. Troiano RN, Taylor KJ. Sonographically guided therapeutic aspiration of benign-appearing ovarian cysts and endometriomas. AJR Am J Roentgenol. 1998;171:1601–5.

    CAS  PubMed  Google Scholar 

  57. Montanino G, Porpora MG, Montanino Oliva M, Gulemi L, Boninfante M, Cosmi EV. Laparoscopic treatment of ovarian endometrioma. One year follow-up. Clin Exp Obstet Gynecol. 1996;23:70–2.

    CAS  PubMed  Google Scholar 

  58. Canis M, Mage G, Wattiez A, Chapron C, Pouly JL, Bassil S. Second-look laparoscopy after laparoscopic cystectomy of large ovarian endometriomas. Fertil Steril. 1992;58:617–9.

    CAS  PubMed  Google Scholar 

  59. Jones KD, Sutton CJ. Laparoscopic management of ovarian endometriomas: a critical review of current practice. Curr Opin Obstet Gynecol. 2000;12:309–15.

    CAS  PubMed  Google Scholar 

  60. Porpora MG, Pallante D, Ferro A, Crisafi B, Bellati F, Benedetti Panici P. Pain and ovarian endometrioma recurrence after laparoscopic treatment of endometriosis: a long-term prospective study. Fertil Steril. 2010;93:716–21. 60. Kikuchi I, Takeuchi H, Kitade M, Shimanuki H, Kumakiri J, Kinoshita K. Recurrence rate of endometriomas following a laparoscopic cystectomy. Acta Obstet Gynecol Scand. 2006;85:1120–24.

    Google Scholar 

  61. Seracchioli R, Mabrouk M, Frasca C, Manuzzi L, Montanari G, Keramyda A, Venturoli S. Long-term cyclic and continuous oral contraceptive therapy and endometrioma recurrence: a randomized controlled trial. Fertil Steril. 2010;93:52–6.

    PubMed  Google Scholar 

  62. Hart RJ, Hickey M, Maouris P, Buckett W. Excisional surgery versus ablative surgery for ovarian endometriomata. Cochrane Database Syst Rev. 2008;16(2):CD004992.

    Google Scholar 

  63. Beretta P, Franchi M, Ghezzi F, Busacca M, Zupi E, Bolis P. Randomized clinical trial of two laparoscopic treatments of endometriomas: cystectomy versus drainage and coagulation. Fertil Steril. 1998;70:1176–80.

    CAS  PubMed  Google Scholar 

  64. Alborzi S, Momtahan M, Parsanezhad ME, Dehbashi S, Zolghadri J. A prospective, randomized study comparing laparoscopic ovarian cystectomy versus fenestration and coagulation in patients with endometriomas. Fertil Steril. 2004;82:1633–7.

    PubMed  Google Scholar 

  65. Carmona F, Martinez-Zamora MA, Rabanal A, Martinez-Roman S, Balasch J. Ovarian cystectomy versus laser vaporization in the treatment of ovarian endometriomas: a randomized clinical trial with a five-year follow-up. Fertil Steril. 2011;96:251–4.

    PubMed  Google Scholar 

  66. Vercellini P, Chapron C, De Giorgi O, Consonni D, Frontino G, Crosignani PG. Coagulation or excision of ovarian endometriomas? Am J Obstet Gynecol. 2003;188:606–10.

    PubMed  Google Scholar 

  67. Hachisuga T, Kawarabayashi T. Histopathological analysis of laparoscopically treated ovarian endometriotic cysts with special reference to loss of follicles. Hum Reprod. 2002;17:432–5.

    PubMed  Google Scholar 

  68. Fedele L, Bianchi S, Zanconato G, Bergamini V, Berlanda N. Bipolar electrocoagulation versus suture of solitary ovary after laparoscopic excision of ovarian endometriomas. J Am Assoc Gynecol Laparosc. 2004;11:344–7.

    PubMed  Google Scholar 

  69. Li CZ, Liu B, Wen ZQ, Sun Q. The impact of electrocoagulation on ovarian reserve after laparoscopic excision of ovarian cysts: a prospective clinical study of 191 patients. Fertil Steril. 2009;92: 1428–35.

    PubMed  Google Scholar 

  70. Chang HJ, Han SH, Lee JR, Jee BC, Lee BI, Suh CS, Kim SH. Impact of laparoscopic cystectomy on ovarian reserve: serial changes of serum anti-Mullerian hormone levels. Fertil Steril. 2010;94:343–9.

    CAS  PubMed  Google Scholar 

  71. Kitajima M, Khan KN, Hiraki K, Inoue T, Fujishita A, Masuzaki H. Changes in serum anti-Mullerian hormone levels may predict damage to residual normal ovarian tissue after laparoscopic surgery for women with ovarian endometrioma. Fertil Steril. 2011;95:2589–91.

    CAS  PubMed  Google Scholar 

  72. Raffi F, Metwyally M, Amer S. The impact of excision of ovarian endometriomas on ovarian reserve: a systematic review and meta-analysis. JCEM. 2012;97:3146–54.

    CAS  PubMed  Google Scholar 

  73. Ercan CM, Duru NK, Karasahin KE, Coksuer H, Dede M, Baser I. Ultrasonographic evaluation and anti-mullerian hormone levels after laparoscopic stripping of unilateral endometriomas. Eur J Obstet Gynecol Reprod Biol. 2011;158:280–4.

    CAS  PubMed  Google Scholar 

  74. Mokdad C, Auber M, Vassilieff M, Diguet A, Bourdel N, Marpeau L, Roman H. Assessment of ovarian volume reduction with three-dimensional ultrasonography after cystectomy for endometrioma. Gynecol Obstet Fertil. 2012;40:4–9.

    CAS  PubMed  Google Scholar 

  75. Auber M, Bourdel N, Mokdad C, Martin C, Diguet A, Marpeau L, Roman H. Ultrasound ovarian assessments after endometrioma ablation using plasma energy. Fertil Steril. 2011;95:2621–4.

    PubMed  Google Scholar 

  76. Roman H, Auber M, Mokdad C, Martin C, Diguet A, Marpeau L, Bourdel N. Ovarian endometrioma ablation using plasma energy versus cystectomy: a step toward better preservation of the ovarian parenchyma in women wishing to conceive. Fertil Steril. 2011;96:1396–400.

    PubMed  Google Scholar 

  77. Donnez J, Lousse JC, Jadoul P, Donnez O, Squifflet J. Laparoscopic management of endometriomas using a combined technique of excisional (cystectomy) and ablative surgery. Fertil Steril. 2010;94:28–32.

    PubMed  Google Scholar 

  78. Celik HG, Dogan E, Okyay E, Ulukus C, Saatli B, Uysal S, Koyuncuoglu M. Effect of laparoscopic excision of endometriomas on ovarian reserve: serial changes in the serum antimüllerian hormone levels. Fertil Steril. 2012;97:1472–8.

    CAS  PubMed  Google Scholar 

  79. Ledger WL. Clinical utility of measurement of anti-mullerian hormone in reproductive endocrinology. J Clin Endocrinol Metab. 2010;95:5144–54.

    CAS  PubMed  Google Scholar 

  80. Suganuma N, Wakahara Y, Ishida D, Asano M, Kitagawa T, Katsumata Y, Moriwaki T, Furuhashi M. Pretreatment for ovarian endometrial cyst before in vitro fertilization. Gynecol Obstet Invest. 2002;54 Suppl 1:36–40; discussion 41–2.

    PubMed  Google Scholar 

  81. Demirol A, Guven S, Baykal C, Gurgan T. Effect of endometrioma cystectomy on IVF outcome: a prospective randomized study. Reprod Biomed Online. 2006;12:639–43.

    PubMed  Google Scholar 

  82. Pabuccu R, Onalan G, Goktolga U, Kucuk T, Orhon E, Ceyhan T. Aspiration of ovarian endometriomas before intracytoplasmic sperm injection. Fertil Steril. 2004;82:705–11.

    PubMed  Google Scholar 

  83. Tsoumpou I, Kyrgiou M, Gelbaya TA, Nardo LG. The effect of surgical treatment for endometrioma on in vitro fertilization outcomes: a systematic review and meta-analysis. Fertil Steril. 2009;92:75–87.

    PubMed  Google Scholar 

  84. Almog B, Sheizaf B, Shalom-Paz E, Shehata F, Al-Talib A, Tulandi T. Effects of excision of ovarian endometrioma on the antral follicle count and collected oocytes for in vitro fertilization. Fertil Steril. 2010;94:2340–2.

    PubMed  Google Scholar 

  85. Somigliana E, Ragni G, Benedetti F, Borroni R, Vegetti W, Crosignani PG. Does laparoscopic excision of endometriotic ovarian cysts significantly affect ovarian reserve? Insights from IVF cycles. Hum Reprod. 2003;18:2450–3.

    CAS  PubMed  Google Scholar 

  86. Ho HY, Lee RK, Hwu YM, Lin MH, Su JT, Tsai YC. Poor response of ovaries with endometrioma previously treated with cystectomy to controlled ovarian hyperstimulation. J Assist Reprod Genet. 2002;19:507–11.

    PubMed Central  PubMed  Google Scholar 

  87. Benaglia L, Somigliana E, Vighi V, Ragni G, Vercellini P, Fedele L. Rate of severe ovarian damage following surgery for endometriomas. Hum Reprod. 2010;25:678–82.

    PubMed  Google Scholar 

  88. Ragni G, Somigliana E, Benedetti F, Paffoni A, Vegetti W, Restelli L, Crosignani PG. Damage to ovarian reserve associated with laparoscopic excision of endometriomas: a quantitative rather than a qualitative injury. Am J Obstet Gynecol. 2005;193:1908–14.

    PubMed  Google Scholar 

  89. Nargund G, Cheng WC, Parsons J. The impact of ovarian cystectomy on ovarian response to stimulation during in-vitro fertilization cycles. Hum Reprod. 1996;11:81–3.

    CAS  PubMed  Google Scholar 

  90. Duru NK, Dede M, Acikel CH, Keskin U, Fidan U, Baser I. Outcome of in vitro fertilization and ovarian response after endometrioma stripping at laparoscopy and laparotomy. J Reprod Med. 2007;52:805–9.

    PubMed  Google Scholar 

  91. Alborzi S, Ravanbakhsh R, Parsanezhad ME, Alborzi M, Dehbashi S. A comparison of follicular response of ovaries to ovulation induction after laparoscopic ovarian cystectomy or fenestration and coagulation versus normal ovaries in patients with endometrioma. Fertil Steril. 2007;88:507–9.

    PubMed  Google Scholar 

  92. Donnez J, Wyns C, Nisolle M. Does ovarian surgery for endometriomas impair the ovarian response to gonadotropin? Fertil Steril. 2001;76:662–5.

    CAS  PubMed  Google Scholar 

  93. Loh FH, Tan AT, Kumar J, Ng SC. Ovarian response after laparoscopic ovarian cystectomy for endometriotic cysts in 132 monitored cycles. Fertil Steril. 1999;72:316–21.

    CAS  PubMed  Google Scholar 

  94. Wu MH, Tsai SJ, Pan HA, Hsiao KY, Chang FM. Three-dimensional power Doppler imaging of ovarian stromal blood flow in women with endometriosis undergoing in vitro fertilization. Ultrasound Obstet Gynecol. 2003;21:480–5.

    PubMed  Google Scholar 

  95. Esinler I, Bozdag G, Aybar F, Bayar U, Yarali H. Outcome of in vitro fertilization/intracytoplasmic sperm injection after laparoscopic cystectomy for endometriomas. Fertil Steril. 2006;85:1730–5.

    PubMed  Google Scholar 

  96. Somigliana E, Arnoldi M, Benaglia L, Iemmello R, Nicolosi AE, Ragni G. IVF-ICSI outcome in women operated on for bilateral endometriomas. Hum Reprod. 2008;23:1526–30.

    PubMed  Google Scholar 

  97. Kahyaoglu S, Ertas E, Kahyaoglu I, Mollamahmutoglu L, Batioglu S. Does laparoscopic cystectomy and cauterization of endometriomas greater than 3 cm diminish ovarian response to controlled ovarian hyperstimulation during IVF-ET? A case-control study. J Obstet Gynaecol Res. 2008;34:1010–3.

    PubMed  Google Scholar 

  98. Loo TC, Lin MY, Chen SH, Chung MT, Tang HH, Lin LY, Tsai YC. Endometrioma undergoing laparoscopic ovarian cystectomy: its influence on the outcome of in vitro fertilization and embryo transfer (IVF-ET). J Assist Reprod Genet. 2005;22:329–33.

    PubMed  Google Scholar 

  99. Matalliotakis IM, Cakmak H, Mahutte N, Fragouli Y, Arici A, Sakkas D. Women with advanced-stage endometriosis and previous surgery respond less well to gonadotropin stimulation, but have similar IVF implantation and delivery rates compared with women with tubal factor infertility. Fertil Steril. 2007;88:1568–72.

    CAS  PubMed  Google Scholar 

  100. Suzuki T, Izumi S, Matsubayashi H, Awaji H, Yoshikata K, Makino T. Impact of ovarian endometrioma on oocytes and pregnancy outcome in in vitro fertilization. Fertil Steril. 2005;83:908–13.

    PubMed  Google Scholar 

  101. Yazbeck C, Madelenat P, Sifer C, Hazout A, Poncelet C. Ovarian endometriomas: effect of laparoscopic cystectomy on ovarian response in IVF-ET cycles. Gynecol Obstet Fertil. 2006;34:808–12.

    CAS  PubMed  Google Scholar 

  102. Wyns C, Donnez J. Laser vaporization of ovarian endometriomas: the impact on the response to gonadotrophin stimulation. Gynecol Obstet Fertil. 2003;31:337–42.

    CAS  PubMed  Google Scholar 

  103. Canis M, Pouly JL, Tamburro S, Mage G, Wattiez A, Bruhat MA. Ovarian response during IVF-embryo transfer cycles after laparoscopic ovarian cystectomy for endometriotic cysts of >3 cm in diameter. Hum Reprod. 2001;16:2583–6.

    CAS  PubMed  Google Scholar 

  104. Marconi G, Vilela M, Quintana R, Sueldo C. Laparoscopic ovarian cystectomy of endometriomas does not affect the ovarian response to gonadotropin stimulation. Fertil Steril. 2002;78:876–8.

    PubMed  Google Scholar 

  105. Nakagawa K, Ohgi S, Kojima R, Sugawara K, Ito M, Horikawa T, Irahara M, Saito H. Impact of laparoscopic cystectomy on fecundity of infertility patients with ovarian endometrioma. J Obstet Gynaecol Res. 2007;33:671–6.

    PubMed  Google Scholar 

  106. Yanushpolsky EH, Best CL, Jackson KV, Clarke RN, Barbieri RL, Hornstein MD. Effects of endometriomas on ooccyte quality, embryo quality, and pregnancy rates in in vitro fertilization cycles: a prospective, case-controlled study. J Assist Reprod Genet. 1998;15:193–7.

    PubMed Central  CAS  PubMed  Google Scholar 

  107. Coccia ME, Rizzello F, Mariani G, Bulletti C, Palagiano A, Scarselli G. Ovarian surgery for bilateral endometriomas influences age at menopause. Hum Reprod. 2011;26:3000–7.

    PubMed  Google Scholar 

  108. Coulam CB, Adamson SC, Annegers JF. Incidence of premature ovarian failure. Obstet Gynecol. 1986;67:604–6.

    CAS  PubMed  Google Scholar 

  109. Busacca M, Riparini J, Somigliana E, Oggioni G, Izzo S, Vignali M, Candiani M. Postsurgical ovarian failure after laparoscopic excision of bilateral endometriomas. Am J Obstet Gynecol. 2006;195:421–5.

    PubMed  Google Scholar 

  110. Parazzini F, et al. Progetto Menopausa Italia Study Group. Determinants of age at menopause in women attending menopause clinics in Italy. Maturitas. 2007;56:280–7.

    Google Scholar 

  111. Horikawa T, Nakagawa K, Ohgi S, Kojima R, Nakashima A, Ito M, Takahashi Y, Saito H. The frequency of ovulation from the affected ovary decreases following laparoscopic cystectomy in infertile women with unilateral endometrioma during a natural cycle. J Assist Reprod Genet. 2008;25:239–44.

    PubMed Central  PubMed  Google Scholar 

  112. Donnez J, Nisolle M, Gillet N, Smets M, Bassil S, Casanas-Roux F. Large ovarian endometriomas. Hum Reprod. 1996;11:641–6.

    CAS  PubMed  Google Scholar 

  113. Elsheikh A, Milingos S, Loutradis D, Kallipolitis G, Michalas S. Endometriosis and reproductive disorders. Ann N Y Acad Sci. 2003;997:247–54.

    CAS  PubMed  Google Scholar 

  114. Vercellini P, Somigliana E, Vigano P, Abbiati A, Barbara G, Crosignani PG. Surgery for endometriosis-associated infertility: a pragmatic approach. Hum Reprod. 2009;24:254–69.

    PubMed  Google Scholar 

  115. Jones KD, Sutton C. Fertility after laparoscopic surgery for endometriomas. Hum Fertil (Camb). 2002;5:117–22.

    Google Scholar 

  116. Shimizu Y, Takashima A, Takahashi K, Kita N, Fujiwara M, Murakami T. Long-term outcome, including pregnancy rate, recurrence rate and ovarian reserve, after laparoscopic laser ablation surgery in infertile women with endometrioma. J Obstet Gynaecol Res. 2010;36:115–8.

    PubMed  Google Scholar 

  117. Benschop L, Farquhar C, van der Poel N, Heineman MJ. Interventions for women with endometrioma prior to assisted reproductive technology. Cochrane Database Syst Rev.10(11):CD008571.

    Google Scholar 

  118. Gupta S, Agarwal A, Agarwal R, Loret de Mola JR. Impact of ovarian endometrioma on assisted reproduction outcomes. Reprod Biomed Online. 2006;13:349–60.

    PubMed  Google Scholar 

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Correspondence to Saad A. K. Amer FRCOG, MSc, MD .

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Amer, S.A.K. (2015). The Impact of Endometrioma and Its Surgical Treatment on Ovarian Reserve and Reproductive Performance. In: Metwally, M., Li, TC. (eds) Reproductive Surgery in Assisted Conception. Springer, London. https://doi.org/10.1007/978-1-4471-4953-8_5

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