Mechano-Electric Interactions and Their Role in Electrical Function of the Heart

Chapter

Abstract

The heart is an electrically controlled and chemically powered mechanical pump. There are complex interactions between cardiac structure and function, including electrophysiology, metabolism, and mechanics. These are based on a multitude of interdigitating regulatory loops with different inherent time-scales. This chapter will focus on the acute cross-talk between electrical and mechanical activity of the heart, and in particular its relevance for normal and abnormal heart rhythms.

Keywords

Excitation-contraction coupling Mechano-electric coupling/mechano-electric feedback Heart Cardiomyocyte Calcium handling Stretch Stretch-activated channel 

Abbreviations

AP

Action potential

AT-II

Angiotensin II

ATP

Adenosine tri-phosphate

[Ca2+]i

Free cytosolic Ca2+ concentration

Ca2+

Calcium

ECC

Excitation-contraction coupling

ET-1

Endothelin-1

ILCOR

International Liaison Committee on Resuscitation

LCC

L-type Ca2+ channel

MEC

Mechano-electric coupling

NCX

Na+/Ca2+ exchanger

NHX

Na+/H+ exchanger

PT

Precordial thump

RyR

Ryanodine receptor

SAC, SACNS, SACK

Stretch activated channels of various ion selectivity

SERCA

Sarcoplamsic/endoplasmic reticulum Ca2+-ATPase

SL

Sarcomere length

SR

Sarcoplasmic reticulum

TnC, TnI, TnT

Troponin C, Troponin I, Troponin T

VF

Ventricular fibrillation

VT

Ventricular tachycardia

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Copyright information

© Springer-Verlag London 2013

Authors and Affiliations

  1. 1.Functional Genomics and Systems BiologyIBM T.J. Watson Research CenterYorktown HeightsUSA
  2. 2.Department of Biomedical EngineeringThe Johns Hopkins UniversityBaltimoreUSA
  3. 3.Department of Cell and Molecular BiologyLoyola UniversityChicagoUSA
  4. 4.Cardiac Biophysics and Systems BiologyNational Heart and Lung Institute, Imperial College of Science, Engineering and Medicine, The Heart Science CentreHarefield, LondonUK
  5. 5.Department of Computer ScienceUniversity of OxfordOxfordUK

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