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Electrophysiological Remodeling in Heart Failure

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Electrical Diseases of the Heart

Abstract

Ion channel remodeling in heart failure modulates key cellular electrophysiological properties, predisposing to arrhythmias and sudden death. Heart failure induced ion channel dysfunction prolongs the action potential, increases spatio-temporal gradients of repolarization, promotes arrhythmogenic triggers and results in conduction abnormalities. Understanding fundamental ionic mechanisms of normal and abnormal electrogenesis is a key requirement for the development of effective and safe therapies. Elucidating the underlying molecular mechanisms and functional consequences of ion channel remodeling at the cellular and organ levels presents a unique opportunity for the development of novel pharmacological, device, gene, and cell based approaches for the treatment of arrhythmias in heart failure.

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Authors and Affiliations

  1. Department of Medicine, Mount Sinai School of Medicine, One Gustave L. Levy Place, Atran 511, 1030, New York, NY, 10029, USA

    Fadi G. Akar PhD, FHRS

  2. Department of Medicine, Cardiovascular Institute, Mount Sinai Medical Center, New York, NY, USA

    Fadi G. Akar PhD, FHRS

  3. Division of Cardiology, Johns Hopkins University, Baltimore, MD, USA

    Gordon F. Tomaselli MD

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  1. Fadi G. Akar PhD, FHRS
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Correspondence to Fadi G. Akar PhD, FHRS .

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  1. , Department of Internal Medicine, UMDNJ-RWJ Medical School, Robert Wood Johnson Pl. 1, New Brunswick, 08903-0019, New Jersey, USA

    Ihor Gussak

  2. , Gordon K. Moe Scholar, Masonic Medical Research Laboratory, Bleecker Street, Utica, 13501-1787, New York, USA

    Charles Antzelevitch

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Akar, F.G., Tomaselli, G.F. (2013). Electrophysiological Remodeling in Heart Failure. In: Gussak, I., Antzelevitch, C. (eds) Electrical Diseases of the Heart. Springer, London. https://doi.org/10.1007/978-1-4471-4881-4_22

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