Abstract
Diabetes mellitus is a significant burden to patients in the United States, with an estimated 10–15 % of the population affected. It remains a major cause of death within the United States. As described by the Diabetes Control and Complications Trial, intensive insulin-based therapy delays the onset and slows the progression of secondary complications of diabetes. These complications include retinopathy, neuropathy, and nephropathy. Although the insulin treatment regimens and modalities have advanced considerably over the past several decades, no patient can truly achieve euglycemia. Patients who are able to maintain very low serum blood sugars have a significantly increased incidence of hypoglycemic incidents, leading to morbidity, decreased quality of life, and mortality.
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Boggi U, Vistoli F, Signori S, Del Chiaro M, Campatelli A, Amorese G, et al. A technique for retroperitoneal pancreas transplantation with portal-enteric drainage. Transplantation. 2005;79:1137–42.
Diabetes Control and Complications Trial Research Group. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N Engl J Med. 1993;329:977–86.
Farney AC, Rogers J, Stratta RJ. Pancreas graft thrombosis: causes, prevention, diagnosis, and intervention. Curr Opin Organ Transplant. 2012;17:87–92.
Gaber AO, Shokouh-Amiri H, Grewal HP, Britt LG. A technique for portal pancreatic transplantation with enteric drainage. Surg Gynecol Obstet. 1993;177:417–9.
Gaber AO, Shokouh-Amiri MH, Hathaway DK, Hammontree L, Kitabchi AE, Gaber LW, et al. Results of pancreas transplantation with portal venous and enteric drainage. Ann Surg. 1995;221:613–22; discussion 622–4.
Gruessner AC. 2011 update on pancreas transplantation: comprehensive trend analysis of 25,000 cases followed up over the course of twenty-four years at the International Pancreas Transplant Registry (IPTR). Rev Diabet Stud. 2011;8:6–16.
Gruessner AC, Gruessner RW. Pancreas transplant outcomes for United States and non United States cases as reported to the United Network for Organ Sharing and the International Pancreas Transplant Registry as of. Clin Transpl. 2011;2012:23–40.
Gruessner RW, Gruessner AC. The current state of pancreas transplantation. Nat Rev Endocrinol. 2013;9:555–62.
Gruessner RW, Sutherland DE. Simultaneous kidney and segmental pancreas transplants from living related donors – the first two successful cases. Transplantation. 1996;61:1265–8.
Gruessner RW, Kendall DM, Drangstveit MB, Gruessner AC, Sutherland DE. Simultaneous pancreas-kidney transplantation from live donors. Ann Surg. 1997;226:471–80; discussion 480–2.
Gruessner RW, Kandaswamy R, Denny R. Laparoscopic simultaneous nephrectomy and distal pancreatectomy from a live donor. J Am Coll Surg. 2001a;193:333–7.
Gruessner RW, Sutherland DE, Drangstveit MB, Bland BJ, Gruessner AC. Pancreas transplants from living donors: short- and long-term outcome. Transplant Proc. 2001b;33:819–20.
Gruessner AC, Sutherland DE, Gruessner RW. Pancreas transplantation in the United States: a review. Curr Opin Organ Transplant. 2010;15:93–101.
Gruessner AC, Sutherland DE, Gruessner RW. Long-term outcome after pancreas transplantation. Curr Opin Organ Transplant. 2012;17:100–6.
Kandaswamy R, Stillman AE, Granger DK, Sutherland DE, Gruessner RW. MRI is superior to angiography for evaluation of living-related simultaneous pancreas and kidney donors. Transplant Proc. 1999;31:604–6.
Kandaswamy R, Stock PG, Skeans MA, Gustafson SK, Sleeman EF, Wainright JL, et al. OPTN/SRTR 2011 annual data report: pancreas. Am J Transplant. 2013;13 Suppl 1:47–72.
Kelly WD, Lillehei RC, Merkel FK, Idezuki Y, Goetz FC. Allotransplantation of the pancreas and duodenum along with the kidney in diabetic nephropathy. Surgery. 1967;61:827–37.
Kercher KW, Heniford BT, Matthews BD, Smith TI, Lincourt AE, Hayes DH, et al. Laparoscopic versus open nephrectomy in 210 consecutive patients: outcomes, cost, and changes in practice patterns. Surg Endosc. 2003;17:1889–96.
Kuo PC, Johnson LB, Schweitzer EJ, Bartlett ST. Simultaneous pancreas/kidney transplantation – a comparison of enteric and bladder drainage of exocrine pancreatic secretions. Transplantation. 1997;63:238–43.
Maglione M, Ploeg RJ, Friend PJ. Donor risk factors, retrieval technique, preservation and ischemia/reperfusion injury in pancreas transplantation. Curr Opin Organ Transplant. 2013;18:83–8.
Martin X, Petruzzo P, Dawahra M, Feitosa Tajra LC, Da Silva M, Pibiri L, et al. Effects of portal versus systemic venous drainage in kidney-pancreas recipients. Transpl Int. 2000;13:64–8.
Philosophe B, Farney AC, Schweitzer EJ, Colonna JO, Jarrell BE, Krishnamurthi V, et al. Superiority of portal venous drainage over systemic venous drainage in pancreas transplantation: a retrospective study. Ann Surg. 2001;234:689–96.
Reddy KS, Stratta RJ, Shokouh-Amiri MH, Alloway R, Egidi MF, Gaber AO. Surgical complications after pancreas transplantation with portal-enteric drainage. J Am Coll Surg. 1999;189:305–13.
Reynoso JF, Gruessner CE, Sutherland DE, Gruessner RW. Short- and long-term outcome for living pancreas donors. J Hepatobiliary Pancreat Sci. 2010;17(2):92–6.
Squifflet JP, Gruessner RW, Sutherland DE. The history of pancreas transplantation: past, present and future. Acta Chir Belg. 2008;108:367–78.
Stratta RJ, Gaber AO, Shokouh-Amiri MH, Reddy KS, Egidi MF, Grewal HP, et al. A prospective comparison of systemic-bladder versus portal-enteric drainage in vascularized pancreas transplantation. Surgery. 2000;127:217–26.
Sutherland DE, Najarian JS, Gruessner R. Living versus cadaver donor pancreas transplants. Transplant Proc. 1998;30(5):2264–6.
Sutherland DE, Radosevich D, Gruessner R, Gruessner A, Kandaswamy R. Pushing the envelope: living donor pancreas transplantation. Curr Opin Organ Transplant. 2012;17:106–16.
Tan M, Kandaswamy R, Sutherland DE, Gruessner RW. Laparoscopic donor distal pancreatectomy for living donor pancreas and pancreas-kidney transplantation. Am J Transplant. 2005;5:1966–70.
Thomas F, Bogey W, Castellani W, Khazanie P, Lust R, Viola C, et al. Diagnosis of pancreatic allograft rejection by measurement of urinary radioimmunoreactive insulin. Transplantation. 1988;45:370–6.
Acknowledgments
A. Osama Gaber and Hosein Shoukouh-Amiri acknowledge the expert assistance of Dr. Mohammad Shokouh-Amiri for preparation of the illustrations and Mrs. Shaherah Rankins-Amos for assistance with manuscript preparation for the section “Simultaneous Pancreas Kidney: Portal/Enteric Drainage”.
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6.1 Electronic Supplementary Material
Below is the link to the electronic supplementary material.
Benching the pancreas from a deceased donor (Humar) (WMV 156889 kb)
Pancreas transplant alone: systemic/bladder drainage (Humar) (WMV 110701 kb)
Simultaneous pancreas kidney (SPK) transplant: portal/enteric drainage (Hosein Shokouh-Amiri, Osama Gaber) (WMV 135741 kb)
Laparoscopic nephrectomy and distal pancreatectomy for living donor kidney and pancreas transplant (Miguel Tan, Raja Kandaswamy, Rainer Gruessner) (WMV 151967 kb)
Total pancreatectomy islet auto transplant (Humar, Wijkstrom, Sturdevant) (MOV 642312 kb)
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Tevar, A.D. et al. (2015). Pancreas Transplantation. In: Humar, A., Sturdevant, M. (eds) Atlas of Organ Transplantation. Springer, London. https://doi.org/10.1007/978-1-4471-4775-6_6
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DOI: https://doi.org/10.1007/978-1-4471-4775-6_6
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