Newborn Urinary Tract Infections

  • Colin Jones
  • Joshua Kausman


Urinary tract infection (UTI) is among the most common bacterial infections affecting newborns. Urinary tract infection can cause septicaemia or chronic ill health with failure to thrive and is often an indication of an underlying urinary tract malformation.


Urinary tract infection Newborns Management Outcomes 


  1. 1.
    Sastre JB, Aparicio AR, Cotallo GD, Colomer BF, Hernandez MC. Grupo de Hospitales Castrillo 2007 Urinary tract infection in the newborn: clinical and radio imaging studies. Pediatr Nephrol. 22; 1735–41.Google Scholar
  2. 2.
    Craig JC, Irwig LM, Knight JF, Sureshkumar P, Roy P. Symptomatic urinary tract infections in pre-school Australian children. J Paediatr Child Health. 1998;34:154–9.CrossRefGoogle Scholar
  3. 3.
    Hanson S, Jodal U. Urinary tract infection. In: Barratt TM, Avner ED, Marmon WE, editors. Paediatric nephrology. Baltimore: Lippincott Williams & Wilkins; 1999. p. 835–50.Google Scholar
  4. 4.
    Levy I, Comarsca J, Davidovits M, et al. Urinary tract infection in preterm infants: the protective role of breast feeding. Pediatr Nephrol. 2009;24:527–31.CrossRefGoogle Scholar
  5. 5.
    Falcao MC, Leone CR, D’Andrea RAP, Berardi R, Ono NA, Vaz FAC. Urinary tract infections in full-term newborn infants: risk factor analysis. Rev Hosp Clin Fac Med S Paulo. 2000;55:9–16.CrossRefGoogle Scholar
  6. 6.
    Patrick MJ. Influence of maternal renal infection on the fetus and infant. Arch Dis Child. 1967;42:208–11.CrossRefGoogle Scholar
  7. 7.
    Manz F, Kalhoff H, Remar T. Renal acid excretion in early infancy. Pediatr Nephrol. 1997;11:231–43.CrossRefGoogle Scholar
  8. 8.
    Becker AM. Postnatal evaluation of infants with an abnormal antenatal renal sonogram. Curr Opin Pediatr. 2009;21:207–13.CrossRefGoogle Scholar
  9. 9.
    Mallik M, Watson AR. Antenatally detected urinary tract abnormalities: more detection but less action. Pediatr Nephrol. 2008;23:897–900.CrossRefGoogle Scholar
  10. 10.
    Wiswell TE, Smith FR, Bass JW. Decreased incidence of urinary tract infections in circumcised male infants. Pediatrics. 1985;75:901–3.Google Scholar
  11. 11.
    Craig J. Urinary tract infection. In: Isaacs D, Moxon ER, editors. A practical approach to pediatric infections. London: Churchill Livingstone; 1996. p. 235–7.Google Scholar
  12. 12.
    Vickers D, Ahmed T, Coulthard MG. Diagnosis of urinary tract infection in children: fresh urine microscopy or culture? Lancet. 1991;338:767–70.CrossRefGoogle Scholar
  13. 13.
    Williams GJ, Macaskill P, Chan SF, Turner RM, Hodson E, Graig J. Absolute and relative accuracy of rapid urine tests for urinary tract infection in children: a meta-analysis. Lancet Infect Dis. 2010;10:240–50.CrossRefGoogle Scholar
  14. 14.
    Kass EH. Asymptomatic infections of the urinary tract. Transactions of the Association of American Physicians. 1956;69:56–64.PubMedPubMedCentralGoogle Scholar
  15. 15.
    Nelson JD, Peters PC. Suprapubic aspiration of urine in premature and term infants. Pediatrics. 1965;36:132–4.PubMedPubMedCentralGoogle Scholar
  16. 16.
    Newman CG, O'Neill P, Parker A. Pyuria in infancy, and the role of suprapubic aspiration of urine in diagnosis of infection of urinary tract. Br Med J. 1967;2:277–9.CrossRefGoogle Scholar
  17. 17.
    Klein JO, Long SS. Bacterial infections of the urinary tract. In: Remington JS, Klein JO, editors. Infections of the fetus and newborn infant. 3rd ed. Philidelphia: WB Saunders; 1995. p. 925–34.Google Scholar
  18. 18.
    de Man P. Bacterial attachment, inflammation and renal scarring in urinary tract infection. Weiner Medizinische Wochenschrift. 1991;141:537–40.Google Scholar
  19. 19.
    Connell I, Agace W, Klemm P, Schembri M, Marild S, Svanborg C. Type 1 fimbrial expression enhances Escherichia coli virulence for the urinaruy tract. Proc Nat Acad Sciences USA. 1996;93:9827–32.CrossRefGoogle Scholar
  20. 20.
    Birmingham Reflux Study Group. Prospective trial of operative versus non-operative treatment of severe vesicoureteric reflux in children: five years observation. BMJ. 1987;295:237–41.Google Scholar
  21. 21.
    Olbing H, Caesson H, Ebel K, Seppanen U, Smellie J, Tamminem-Mobius T, Wikstad I. Renal scars and parenchymal thinning in children with vesico ureteral reflux: a 5-year report of the International Reflux Study in Children (European Branch). J Urol. 1992;148:1653–6.CrossRefGoogle Scholar
  22. 22.
    Weiss R, Duckett J, Spitzer A. Results of a randomized clinical trial of medical versus surgical management of infants and children with grade III and IV primary vesicoureteral reflux (United States). J Urol. 1992;148:1667–73.CrossRefGoogle Scholar
  23. 23.
    International Reflux Study Committee. Medical versus surgical treatment of primary vesico-uretereral reflux. Pediatrics. 1981;67:392–400.Google Scholar
  24. 24.
    Risdon RA, Yeung CK, Ransley P. reflux nephropathy in children submitted to unilateral nephrectomy: a clinicopathological study. Clin Nephrol. 1993;40:308–14.Google Scholar
  25. 25.
    Song R, Yosypiv IV. Genetics of congenital anomalies of the kidney and urinary tract. Pediatr Nephrol. 2011;26:353–64.CrossRefGoogle Scholar
  26. 26.
    Mei C, Jia J, Lui Y, Dai B. Long term antibiotics for the prevention of recurrent urinary tract infection in children: a systematic review and meta-analysis. Arch Dis Child. 2010;95:499–508.Google Scholar
  27. 27.
    NICE. Urinary tract infection: diagnosis, treatment and long term management of urinary tract infection in children. London: National Institute for Health and Clinical Excellence; 2007.
  28. 28.
    Wheeler D, Vimalochandra D, Hodson EM, Roy LP, Smith G, Craig JC. Antibiotics and surgery for vesicoureteric reflux: A meta-analysis of randomized controlled trials. Arch Dis Child. 2003;88:688–94.CrossRefGoogle Scholar

Copyright information

© Springer-Verlag London Ltd., part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of NephrologyRoyal Children’s HospitalMelbourneAustralia
  2. 2.University of MelbourneParkvilleAustralia
  3. 3.Department of NephrologyMurdoch Childrens Research InstituteParkvilleAustralia

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