Skip to main content
SpringerLink
Log in
Book cover

Rickham's Neonatal Surgery pp 1113–1123Cite as

Ovarian and Genital Tract Neoplasms

  • Chapter
  • First Online:

  • 2010 Accesses

Abstract

Neonatal tumors occur every 12,500–27,500 live births and ovarian and female genital tract tumors are reported as rare cases in the literature.

Ovarian tumor is an exceptional condition in neonates and, in contrast to older children, sex-cord-stromal tumors are the most frequently reported symptomatic neoplasms.

Considering gynecological neoplasms, a vaginal bleeding in a female neonate should always alert on the risk of vaginal malignant neoplasm with rhabdomyosarcoma and malignant germ cell tumors as the first tumoral types encountered.

Neonatal tumors occur every 12,500–27,500 live births and ovarian and female genital tract tumors are reported as rare cases in the literature.

Ovarian tumor is an exceptional condition in neonates and, in contrast to older children, sex-cord-stromal tumors are the most frequently reported symptomatic neoplasms.

Considering gynecological neoplasms, a vaginal bleeding in a female neonate should always alert on the risk of vaginal malignant neoplasm with rhabdomyosarcoma and malignant germ cell tumors as the first tumoral types encountered

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   99.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   129.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   199.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

References

  1. Cass DL, Hawkins E, Brandt ML, Chintagumpala M, Bloss RS, Milewicz AL, et al. Surgery for ovarian masses in infants, children, and adolescents: 102 consecutive patients treated in a 15-year period. J Pediatr Surg. 2001;36(5):693–9.

    Article  CAS  PubMed  Google Scholar 

  2. von Allmen D. Malignant lesions of the ovary in childhood. Semin Pediatr Surg. 2005;14(2):100–5.

    Article  Google Scholar 

  3. Schultz KA, Sencer SF, Messinger Y, Neglia JP, Steiner ME. Pediatric ovarian tumors: a review of 67 cases. Pediatr Blood Cancer. 2005;44(2):167–73.

    Article  PubMed  Google Scholar 

  4. De Backer A, Madern GC, Oosterhuis JW, Hakvoort-Cammel FG, Hazebroek FW. Ovarian germ cell tumors in children: a clinical study of 66 patients. Pediatr Blood Cancer. 2006;46(4):459–64.

    Article  PubMed  Google Scholar 

  5. Young RH. Sex cord-stromal tumors of the ovary and testis: their similarities and differences with consideration of selected problems. Mod Pathol. 2005;18(Suppl 2):S81–98.

    Article  PubMed  Google Scholar 

  6. Schneider D, Orbach D, Cecchetto G, Stachowicz-Stencel T, Brummel B, Brecht I, et al. Ovarian sertoli Leydig cell tumours in children and adolescents: an analysis of the European Cooperative Study Group on Pediatric Rare Tumors (EXPeRT). Eur J Cancer. 2015;51(4):543–50.

    Article  PubMed  Google Scholar 

  7. Schneider DT, Calaminus G, Harms D, Gobel U. Ovarian sex cord-stromal tumors in children and adolescents. J Reprod Med. 2005;50(6):439–46.

    PubMed  Google Scholar 

  8. Capito C, Flechtner I, Thibaud E, Emond S, Kalfa N, Jaubert F, et al. Neonatal bilateral ovarian sex cord stromal tumors. Pediatr Blood Cancer. 2009;52(3):401–3.

    Article  PubMed  Google Scholar 

  9. Nitzsche K, Kamin G, Dittert DD, Bier A, Distler W. [Fetal juvenile granulosa cell tumor with hermaphroditism verus—prenatal diagnosis, management and outcome]. Ultraschall Med. 2009;30(4):404–7.

    Google Scholar 

  10. Rauber G, Duprez A, Bardaji O. [Ruptured neonatal ovarian cyst with theca cells]. Arch Anat Pathol (Paris). 1964;12:221–4.

    Google Scholar 

  11. Tsakiri SP, Turk CA, Lally KP, Garg K, Morris B. Atypical Meigs’ syndrome in a neonate with ovarian torsion associated with an ovarian dermoid cyst. Pediatr Surg Int. 2005;21(5):407–9.

    Article  PubMed  Google Scholar 

  12. Meizner I, Levy A, Katz M, Maresh AJ, Glezerman M. Fetal ovarian cysts: prenatal ultrasonographic detection and postnatal evaluation and treatment. Am J Obstet Gynecol. 1991;164(3):874–8.

    Article  CAS  PubMed  Google Scholar 

  13. Schneider DT, Janig U, Calaminus G, Gobel U, Harms D. Ovarian sex cord-stromal tumors—a clinicopathological study of 72 cases from the Kiel Pediatric Tumor Registry. Virchows Arch. 2003;443(4):549–60.

    Article  PubMed  Google Scholar 

  14. Bonnevalle M, Mazingue F, Nelken B, Vaast P, Lecomte-Houcke M, Debeugny P. [Precocious pseudo-puberty in granulosa cell tumor in children less than 1 year old. 2 cases]. Chir Pediatr. 1990;31(1):32–4.

    Google Scholar 

  15. Cronje HS, Niemand I, Bam RH, Woodruff JD. Granulosa and theca cell tumors in children: a report of 17 cases and literature review. Obstet Gynecol Surv. 1998;53(4):240–7.

    Article  CAS  PubMed  Google Scholar 

  16. Merras-Salmio L, Vettenranta K, Mottonen M, Heikinheimo M. Ovarian granulosa cell tumors in childhood. Pediatr Hematol Oncol. 2002;19(3):145–56.

    Article  PubMed  Google Scholar 

  17. Zaloudek C, Norris HJ. Granulosa tumors of the ovary in children: a clinical and pathologic study of 32 cases. Am J Surg Pathol. 1982;6(6):503–12.

    Article  CAS  PubMed  Google Scholar 

  18. Plantaz D, Flamant F, Vassal G, Chappuis JP, Baranzelli MC, Bouffet E et al. [Granulosa cell tumors of the ovary in children and adolescents. Multicenter retrospective study in 40 patients aged 7 months to 22 years]. Arch Fr Pediatr. 1992;49(9):793–8.

    Google Scholar 

  19. Truss L, Dobin SM, Rao A, Donner LR. Overexpression of the BCL2 gene in a Sertoli-Leydig cell tumor of the ovary: a pathologic and cytogenetic study. Cancer Genet Cytogenet. 2004;148(2):118–22.

    Article  CAS  PubMed  Google Scholar 

  20. Oliva E, Alvarez T, Young RH. Sertoli cell tumors of the ovary: a clinicopathologic and immunohistochemical study of 54 cases. Am J Surg Pathol. 2005;29(2):143–56.

    Article  PubMed  Google Scholar 

  21. Virgone C, Cecchetto G, Ferrari A, Bisogno G, Donofrio V, Boldrini R, et al. GATA-4 and FOG-2 expression in pediatric ovarian sex cord-stromal tumors replicates embryonal gonadal phenotype: results from the TREP project. PLoS One. 2012;7(9):e45914. https://doi.org/10.1371/journal.pone.0045914. Epub 2012 Sep 24

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  22. Faure A, Atkinson J, Bouty A, O’Brien M, Levard G, Hutson J, et al. DICER1 pleuropulmonary blastoma familial tumour predisposition syndrome: what the paediatric urologist needs to know. J Pediatr Urol. 2016;12(1):5–10.

    Article  PubMed  Google Scholar 

  23. Isaacs H Jr. Perinatal (fetal and neonatal) germ cell tumors. J Pediatr Surg. 2004;39(7):1003–13.

    Article  PubMed  Google Scholar 

  24. Lakhoo K. Neonatal teratomas. Early Hum Dev. 2010;86(10):643–47.

    Article  PubMed  Google Scholar 

  25. Heling KS, Chaoui R, Kirchmair F, Stadie S, Bollmann R. Fetal ovarian cysts: prenatal diagnosis, management and postnatal outcome. Ultrasound Obstet Gynecol. 2002;20(1):47–50.

    Article  PubMed  Google Scholar 

  26. Mittermayer C, Blaicher W, Grassauer D, Horcher E, Deutinger J, Bernaschek G, et al. Fetal ovarian cysts: development and neonatal outcome. Ultraschall Med. 2003;24(1):21–6.

    Article  CAS  PubMed  Google Scholar 

  27. Dolgin SE. Ovarian masses in the newborn. Semin Pediatr Surg. 2000;9(3):121–7.

    Article  CAS  PubMed  Google Scholar 

  28. Gittleman AM, Price AP, Coren C, Akhtar M, Donovan V, Katz DS. Juvenile granulosa cell tumor. Clin Imaging. 2003;27(4):221–4.

    Article  PubMed  Google Scholar 

  29. Gui T, Cao D, Shen K, Yang J, Zhang Y, Yu Q, et al. A clinicopathological analysis of 40 cases of ovarian Sertoli-Leydig cell tumors. Gynecol Oncol. 2012;127(2):384–9.

    Article  PubMed  Google Scholar 

  30. Billmire D, Vinocur C, Rescorla F, Cushing B, London W, Schlatter M, et al. Outcome and staging evaluation in malignant germ cell tumors of the ovary in children and adolescents: an intergroup study. J Pediatr Surg. 2004;39(3):424–9.

    Article  CAS  PubMed  Google Scholar 

  31. Fernandez-Pineda I, Spunt SL, Parida L, Krasin MJ, Davidoff AM, Rao BN. Vaginal tumors in childhood: the experience of St. Jude Children’s Research Hospital. J Pediatr Surg. 2011;46(11):2071–5.

    Article  PubMed  PubMed Central  Google Scholar 

  32. Martelli H, Oberlin O, Rey A, Godzinski J, Spicer RD, Bouvet N, et al. Conservative treatment for girls with nonmetastatic rhabdomyosarcoma of the genital tract: a report from the Study Committee of the International Society of Pediatric Oncology. J Clin Oncol. 1999;17(7):2117–22.

    Article  CAS  PubMed  Google Scholar 

  33. Spicer RD. Neonatal sarcoma. Early Hum Dev. 2010;86(10):633–6.

    Article  PubMed  Google Scholar 

  34. Groff DB. Pelvic neoplasms in children. J Surg Oncol. 2001;77(1):65–71.

    Article  CAS  PubMed  Google Scholar 

  35. Magne N, Oberlin O, Martelli H, Gerbaulet A, Chassagne D, Haie-Meder C. Vulval and vaginal rhabdomyosarcoma in children: update and reappraisal of Institut Gustave Roussy brachytherapy experience. Int J Radiat Oncol Biol Phys. 2008;72(3):878–83.

    Article  PubMed  Google Scholar 

  36. Merlino G, Helman LJ. Rhabdomyosarcoma—working out the pathways. Oncogene. 1999;18(38):5340–8.

    Article  CAS  PubMed  Google Scholar 

  37. Alaggio R, Zhang L, Sung Y, Huang S, Chen C, Bisogno G, et al. A molecular study of Pediatric spindle and sclerosing Rhabdomyosarcoma: identification of novel and recurrent VGLL2-related fusions in infantile cases. Am J Surg Pathol. 2016;40(2):224–35.

    PubMed  PubMed Central  Google Scholar 

  38. Linardic CM. PAX3-FOX01 fusion gene in rhabdomyosarcoma. Cancer Lett. 2008;270(1):10–8.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  39. Naini S, Etheridge KT, Adam SJ, Qualman SJ, Bentley RC, Counter CM, et al. Defining the cooperative genetic changes that temporally drive alveolar rhabdomyosarcoma. Cancer Res. 2008;68(23):9583–8.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  40. Arafah M, Zaidi SN. A case of yolk sac tumor of the vagina in an infant. Arch Gynecol Obstet. 2012;285(5):1403–5.

    Article  PubMed  Google Scholar 

  41. Watanabe N, Okita H, Matsuoka K, Kiyotani C, Fujii E, Kumagai M, et al. Vaginal yolk sac (endodermal sinus) tumors in infancy presenting persistent vaginal bleeding. J Obstet Gynaecol Res. 2010;36(1):213–6.

    Article  PubMed  Google Scholar 

  42. Kalfa N, Paris F, Soyer-Gobillard M, Daures J, Sultan C. Prevalence of hypospadias in grandsons of women exposed to diethylstilbestrol during pregnancy: a multigenerational national cohort study. Fertil Steril. 2011;95(8):2574–7.

    Article  CAS  PubMed  Google Scholar 

  43. Dillon PW, Whalen TV, Azizkhan RG, Haase GM, Coran AG, King DR, et al. Neonatal soft tissue sarcomas: the influence of pathology on treatment and survival. Children’s Cancer Group Surgical Committee. J Pediatr Surg. 1995;30(7):1038–41.

    Article  CAS  PubMed  Google Scholar 

  44. Grosfeld JL, Weber TR, Weetman RM, Baehner RL. Rhabdomyosarcoma in childhood: analysis of survival in 98 cases. J Pediatr Surg. 1983;18(2):141–6.

    Article  CAS  PubMed  Google Scholar 

  45. Crist WM, Anderson JR, Meza JL, Fryer C, Raney RB, Ruymann FB, et al. Intergroup rhabdomyosarcoma study-IV: results for patients with nonmetastatic disease. J Clin Oncol. 2001;19(12):3091–102.

    Article  CAS  PubMed  Google Scholar 

  46. Minard-Colin V, Orbach D, Martelli H, Bodemer C, Oberlin O. [Soft tissue tumors in neonates]. Arch Pediatr. 2009;16(7):1039–48.

    Google Scholar 

  47. Lacy J, Capra M, Allen L. Endodermal sinus tumor of the infant vagina treated exclusively with chemotherapy. J Pediatr Hematol Oncol. 2006;28(11):768–71.

    Article  PubMed  Google Scholar 

  48. Mauz-Korholz C, Harms D, Calaminus G, Gobel U. Primary chemotherapy and conservative surgery for vaginal yolk-sac tumour. Maligne Keimzelltumoren Study Group. Lancet. 2000;355(9204):625.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pediatric Surgery, AP-HP, Hôpital Necker Enfants-Malades, Université Paris Descartes, 149 Rue de Sèvres, 75015, Paris, France

    Carmen Capito MD & Sabine Sarnacki MD, PhD

  2. Department of Pediatric, Adolescent, Young Adult, Institut Curie, Paris, France

    Daniel Orbach MD

Authors
  1. Carmen Capito MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Daniel Orbach MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Sabine Sarnacki MD, PhD
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Sabine Sarnacki MD, PhD .

Editor information

Editors and Affiliations

  1. Division of Child Health, Alder Hey Children’s NHS Foundation Trust, Liverpool, United Kingdom

    Paul D. Losty

  2. University of Pennsylvania , Philadelphia, Pennsylvania, USA

    Alan W. Flake

  3. Childrens Hospital, University of Helsinki, Helsinki, Finland

    Risto J. Rintala

  4. Royal Children’s Hospital, University of Melbourne, Parkville, Victoria, Australia

    John M. Hutson

  5. Department of Surgery, Meiji University of Integrative Medicine, Kyoto, Japan

    Naomi lwai

Rights and permissions

Reprints and permissions

Copyright information

© 2018 Springer-Verlag London Ltd., part of Springer Nature

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Capito, C., Orbach, D., Sarnacki, S. (2018). Ovarian and Genital Tract Neoplasms. In: Losty, P., Flake, A., Rintala, R., Hutson, J., lwai, N. (eds) Rickham's Neonatal Surgery. Springer, London. https://doi.org/10.1007/978-1-4471-4721-3_60

Download citation

  • DOI: https://doi.org/10.1007/978-1-4471-4721-3_60

  • Published:

  • Publisher Name: Springer, London

  • Print ISBN: 978-1-4471-4720-6

  • Online ISBN: 978-1-4471-4721-3

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation