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Developmental Physiology and Pharmacotherapy in Pediatric Surgical Newborns

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Abstract

Human development consists of a continuum of physiologic events that includes somatic growth, neurobehavioral maturation and eventual reproduction, and is often divided into infancy, childhood, adolescence and early adulthood. Across this period of time organ size and function change as does body composition, protein expression, and cellular function. Some tissues may be more sensitive to effects early in life whereas later in life function may decline. This holds true in particular when organ development has resulted in major congenital anomalies. As these developmental changes in function and form occur, their implications with respect to the clinical pharmacology of drugs and their appropriate place in pediatric therapy must be considered.

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Authors and Affiliations

  1. Erasmus Medical Center, Sophia Children’s Hospital, Rotterdam, The Netherlands

    John N. van den Anker MD, PhD

  2. Department of Intensive Care, Erasmus Medical Center, Sophia Children’s Hospital, Rotterdam, The Netherlands

    Dick Tibboel MD, PhD

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  1. John N. van den Anker MD, PhD
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  2. Dick Tibboel MD, PhD
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Correspondence to Dick Tibboel MD, PhD .

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Editors and Affiliations

  1. Division of Child Health, Alder Hey Children’s NHS Foundation Trust, Liverpool, United Kingdom

    Paul D. Losty

  2. University of Pennsylvania , Philadelphia, Pennsylvania, USA

    Alan W. Flake

  3. Childrens Hospital, University of Helsinki, Helsinki, Finland

    Risto J. Rintala

  4. Royal Children’s Hospital, University of Melbourne, Parkville, Victoria, Australia

    John M. Hutson

  5. Department of Surgery, Meiji University of Integrative Medicine, Kyoto, Japan

    Naomi lwai

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van den Anker, J.N., Tibboel, D. (2018). Developmental Physiology and Pharmacotherapy in Pediatric Surgical Newborns. In: Losty, P., Flake, A., Rintala, R., Hutson, J., lwai, N. (eds) Rickham's Neonatal Surgery. Springer, London. https://doi.org/10.1007/978-1-4471-4721-3_6

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