Tumors of the Head and Neck

  • Tomoaki Taguchi
  • Toshiharu Matsuura
  • Yoshiaki Kinoshita


Tumors of the head and neck in neonate, which pediatric surgeons encounter, are limited. They can be divided into three categories based on clinical manifestations; (1) Frontonasal mass, (2) Tumor in the oral cavity, and (3) cervical mass.


Head and neck tumours Newborn surgery Classification Management 


  1. 1.
    Grzegorczyk V, Brasseur-Daudruy M, Labadie G, Cellier C, Verspyck E. Prenatal diagnosis of a nasal glioma. Pediatr Radiol. 2010;40:1706–9.CrossRefGoogle Scholar
  2. 2.
    Gatillo M. Congenital abnormalities of the nose: CT and MR findings. AJR Am J Roentgenol. 1994;162:1211–7.CrossRefGoogle Scholar
  3. 3.
    Hedlund G. Congenital frontonasal masses: developmental anatomy, malformations, and MR imaging. Pediatr Radiol. 2006;36:647–62.CrossRefGoogle Scholar
  4. 4.
    Eghbalian F, Monsef A. Congenital epuris in the newborn, review of the literature and a case report. J Pediatr Hematol Oncol. 2009;31:198–9.CrossRefGoogle Scholar
  5. 5.
    Kanotra S, Kanotra SP, Paul J. Congenital epuris, review of literature. J Laryngol Otol. 2006;120:148–50.CrossRefGoogle Scholar
  6. 6.
    Tantiwongkosi B, Goske MJ, Steele M. Congenital solid neck mass: a unique presentation of Langerhans cell histiocytosis. Pediatr Radiol. 2008;38:575–8.CrossRefGoogle Scholar
  7. 7.
    Neidich MJ, Prager JD, Clark SL, Elluru RG. Comprehensive airway management of neonatal head and neck teratomas. Otolaryngol Head Neck Surg. 2011;144:257–61.CrossRefGoogle Scholar
  8. 8.
    Schmidt MB. Ueber seltene Spaltbildungen im Bereich des mittleren Stirnfortsatzes. Arch Pathol Anat Physiol Klin Med. 1900;162:340–70.CrossRefGoogle Scholar
  9. 9.
    Rahbar R, Resto VA, Robson CD, Perez-Atayde AR, Goumnerova LC, McGill TJ, Healy GB. Nasal glioma and encephalocele: diagnosis and management. Laryngoscope. 2003;113:2069–77.CrossRefGoogle Scholar
  10. 10.
    Puppala B, Mangurten HH, McFadden J, Lygizos N, Taxy J, Pellettiere E. Nasal glioma presenting as neonatal respiratory distress. Definition of the tumor mass by MRI. Clin Pediatr (Phila). 2009;29:49–52.CrossRefGoogle Scholar
  11. 11.
    Uzunlar AK, Osma U, Yilmaz F, Topeu I. Nasal glioma: report of two cases. Turk J Med Sci. 2001;31:|87–90.Google Scholar
  12. 12.
    Barkovich AJ, Vandermarck P, Edwrds MS, Cogen PH. Congenital nasal mass: CT and MR imaging features in 16 cases. AJNR Am J Neuroradiol. 1991;12:105–16.Google Scholar
  13. 13.
    Ma K, Cheung KL. Nasal glioma. Hong Kong Med J. 2006;12:477–9.Google Scholar
  14. 14.
    Hoeger PH, Schaefer H, Ussmueller J, Helmke K. Nasal glioma presenting as capillary haemangioma. Eur J Pediatr. 2001;160:84–7.CrossRefGoogle Scholar
  15. 15.
    McQuown SA, Smith JD, Gallo AE Jr. Intracranial extension of nasal dermoids. Neurosurgery. 1983;12:531–5.CrossRefGoogle Scholar
  16. 16.
    Hoving EW, Vermeij-Keers C. Frontoethomoidal encephaloceles, a study of their pathogenesis. Pediatr Neurosurg. 1997;27:246–56.CrossRefGoogle Scholar
  17. 17.
    Mulliken JB, Glowacki J. Hemangiomas and vascular malformations in infants and children: a classification based on endothelial characteristics. Plast Reconstr Surg. 1982;69:412–22.CrossRefGoogle Scholar
  18. 18.
    Hideno A, Nakajima S. Earliest features of the strawberry mark in the newborn. Br J Dermatol. 1972;87:138–44.CrossRefGoogle Scholar
  19. 19.
    Boye E, Jinnin M, Olsen BR. Infantile hemangioma: challenges, new insights and therapeutic promise. J Craniofac Surg. 2009;20:678–84.CrossRefGoogle Scholar
  20. 20.
    Léauté-Labrèze C, Dumas de la Roque E, Hubiche T, Boralevi F, Thambo JB, Taïeb A. Propranolol for severe hemangiomas of infancy. N Engl J Med. 2008;358:2649–51.CrossRefGoogle Scholar
  21. 21.
    Jinnin M, Medici D, Park L, Limaye N, Liu Y, Boscolo E, Bischoff J, Vikkula M, Boye E, Olsen BR. Suppressed NFAT-dependent VEGFR1 expression and constitutive VEGFR2 signaling in infantile hemangioma. Nat Med. 2008;14:1236–46.CrossRefGoogle Scholar
  22. 22.
    Glade Bender JL, Adamson PC, Reid JM, Xu L, Baruchel S, Shaked Y, Kerbel RS, Cooney-Qualter EM, Stempak D, Chen HX, Nelson MD, Krailo MD, Ingle AM, Blaney SM, Kandel JJ, Yamashiro DJ; Children’s Oncology Group Study. Phase I trial and pharmacokinetic study of bevacizumab in pediatric patients with refractory solid tumors: a Children’s Oncology Group Study. J Clin Oncol. 2008;26:399–405.CrossRefGoogle Scholar
  23. 23.
    Lobe TE, Wiener ES, Hays DM, Lawrence WH, Andrassy RJ, Johnston J, Wharam M, Webber B, Ragab A. Neonatal rhabdomyosarcoma: the IRS experience. J Pediatr Surg. 1994;29:1167–70.CrossRefGoogle Scholar
  24. 24.
    Dillon PW, Whalen TV, Azizkhan RG, Haase GM, Coran AG, King DR, Smith M. Neonatal soft tissue sarcoma: the influence of pathology on treatment and survival. The Children Cancer Group Surgical Committee. J Pediatr Surg. 1995;30:1038–41.CrossRefGoogle Scholar
  25. 25.
    Chigurupati R, Alfatooni A, Myall RMT, Hawkins D, Oda D. Orofacial rhabdomyosarcoma in neonates and young children: a review of literature and management of four cases. Oral Oncol. 2002;38:508–15.CrossRefGoogle Scholar
  26. 26.
    Stout AP. Juvenile fibromatosis. Cancer. 1954;7:953–78.CrossRefGoogle Scholar
  27. 27.
    Conley J, Healey WV, Stout AP. Fibromatosis of the head and neck. Am J Surg. 1966;112:609–14.CrossRefGoogle Scholar
  28. 28.
    Chung EB, Enzinger FM. Infantile myofibromatosis. Cancer. 1981;48:1807–18.CrossRefGoogle Scholar
  29. 29.
    Fukasawa Y, Ishikura H, Takada A, Yokoyama S, Imamura M, Yoshiki T, Sato H. Massive apoptosis in infantile myofibromatosis: a putative mechanism of tumor regression. Am J Pathol. 1994;144:480–5.PubMedPubMedCentralGoogle Scholar
  30. 30.
    Pham NS, Poirier B, Fuller SC, Dublin AB, Tollefson TT. Pediatric lipoblastoma in the head and neck: A systematic review of 48 reported cases. Int J Pediatr Otorhinolaryngol. 2010;74:723–8.CrossRefGoogle Scholar
  31. 31.
    Dogan R, Kara M, Firat P, Gedikoglu G. An usual tumor of the neck and mediastinum: lipoblastomatosis resulting in paraparesis. Eur J Cardiothorac Surg. 2007;31:325–7.CrossRefGoogle Scholar
  32. 32.
    Kieran SM, Robson CD, Nose V, Rahbar R. Foregut duplication cysts in the head and neck. Presentation, diagnosis, and management. Arch Otolaryngol Head Neck Surg. 2010;136:778–82.CrossRefGoogle Scholar
  33. 33.
    Volchok J, Jaffer A, Cooper T, Al-Sabbagh A, Cavalli G. Adenocarcinoma arising in a lingual foregut duplication cyst. Arch Otolaryngol Head Neck Surg. 2007;133:717–9.CrossRefGoogle Scholar
  34. 34.
    Neumann E. Congenital epuris. Arch Heilk. 1871;12:189–90.Google Scholar
  35. 35.
    Leocata P, Bifaretti G, Saltarelli S, Corbacelli A, Ventura L. Congenital (granular cell) epuris of the newborn: a case report with immunohistochemical study on the histogenesis. Ann Saudi Med. 1999;19:527–9.CrossRefGoogle Scholar
  36. 36.
    Ritwik P, Brannon RB, Musselman RJ. Spontaneous regression of congenital epuris: a case report and review of the literature. J Med Case Reports. 2010;4:331–4.CrossRefGoogle Scholar
  37. 37.
    Isaacs H Jr. Perinatal (fetal and neonatal) germ cell tumors. J Pediatr Surg. 2004;39:1003–13.CrossRefGoogle Scholar
  38. 38.
    Isaacs H Jr. Tumors. In: Gilbert-Barness E, editor. Potter’s pathology of the fetus and infant, vol. 2. St Louis: Mosby; 1997. p. 1242–339.Google Scholar
  39. 39.
    Batra P, Saha A. Images in clinical practice. Congenital cervical teratoma. Indian Pediatr. 2006;43:549.Google Scholar
  40. 40.
    Azizkhan RG, Haase GM, Applebaum H, Dillon PW, Coran AG, King PA, King DR, Hodge DS. Diagnosis, management, and outcome of cervicofacial teratomas in neonates: A Childrens Cancer Group Study. J Pediatr Surg. 1995;30:312–6.CrossRefGoogle Scholar
  41. 41.
    Valente A, Grant C, Orr JD, et al. Neonatal tonsillar teratoma. J Pediatr Surg. 1988;23:364–6.CrossRefGoogle Scholar
  42. 42.
    Smith NM, Chambers SE, Billson VR, Laing I, West CP, Bell JE. Oral teratoma (epignathus) with intracranial extension. A report of two cases. Perinat Diagn. 1993;13:945–52.CrossRefGoogle Scholar
  43. 43.
    Wilson JW, Gehweiler JA. Teratoma of the face associated with a patent canal extending into the cranial cavity (Rathke’s pouch) in a three-week-old child. J Pediatr Surg. 1970;5:349–59.CrossRefGoogle Scholar

Copyright information

© Springer-Verlag London Ltd., part of Springer Nature 2018

Authors and Affiliations

  • Tomoaki Taguchi
    • 1
  • Toshiharu Matsuura
    • 1
  • Yoshiaki Kinoshita
    • 1
  1. 1.Department of Pediatric SurgeryGraduate School of Medical Sciences, Kyushu UniversityFukuokaJapan

Personalised recommendations