Neonatal Brain Tumours

  • Chris Barton
  • Jothy Kandasamy
  • Benedetta Pettorini
  • Conor L. Mallucci
  • Barry Pizer


Neonatal brain tumours (NBT) are a rare but important group of neoplasms within the field of paediatric neuro-oncology as they present particular technical and physiological challenges to the neuro-surgical team. Contemporary management requires the application of appropriate multimodal individualised therapeutic approaches.

Neonatal brain tumours (NBT) are a rare but important group of neoplasms within the field of paediatric neuro-oncology as they present particular technical and physiological challenges to the neuro-surgical team. Contemporary management requires the application of appropriate multimodal individualised therapeutic approaches.


CNS tumours Newborn brain tumours Management outcome 


  1. 1.
    Massimi L, Pettorini B, Tamburrini G, Caldarelli M, Di Rocco C. Advances in the management of brain tumours in infants. Curr Cancer Ther Rev. 2011;7(3):184–200.CrossRefGoogle Scholar
  2. 2.
    Manoranjan B, Provias JP. Congenital brain tumours: diagnostic pitfalls and therapeutic interventions. J Child Neurol. 2010;26(5):599–614.CrossRefGoogle Scholar
  3. 3.
    Isaacs H Jr. I. Perinatal brain tumours: a review of 250 cases. Pediatr Neurol. 2002;27(4):249–61.CrossRefGoogle Scholar
  4. 4.
    Moore SW, Satge D, Sasco AJ, Zimmerman A, Plaschkes J. The epidemiology of neonatal tumours. Report of an international working group. Pediatr Surg Int. 2003;19(7):509–19.CrossRefGoogle Scholar
  5. 5.
    Cordier S, Monfort C, Filipinni G, Preston-Martin S, Lubin F, Mueller BA, Holly EA, Peris-Bonet R, McRedie M, Choi W, Little J, Arslan A. Parental exposure to polycyclic aromatic hydrocarbons and the risk of childhood brain tumours: the SEARCH international childhood brain tumours study. Am J Epidemiol. 2004;159(12):1109–16.CrossRefGoogle Scholar
  6. 6.
    Magdum SA. Neonatal brain tumours - a review. Early Hum Dev. 2010;86(10):627–31.CrossRefGoogle Scholar
  7. 7.
    Shamji MF, Vassilyadi M, Lam CH, Montes JL, Farmer JP. Congenital tumours of the central nervous system: the MCH experience. Pediatr Neurosurg. 2009;45(5):368–74.CrossRefGoogle Scholar
  8. 8.
    Serowka K, Chiu Y, Gonzalez I, Gilles F, McComb G, Krieger M, Dhall G, Britt LJ, Sposto R, Finlay JL. Central nervous system (CNS) tumours in the first six months of life: the Children’s Hospital Los Angeles Experience, 1979-2005. Paediatr Haematol Oncol. 2010;27(2):90–102.CrossRefGoogle Scholar
  9. 9.
    Young HK, Johnston H. Intracranial tumours in infants. J Child Neurol. 2004;19(6):424–30.CrossRefGoogle Scholar
  10. 10.
    Saunders DE, Thompson C, Gunny R, Jones R, Cox T, Chong WK. Magnetic resonance imaging protocols for paediatric neurology. Pediatr Radiol. 2007;37:789–97.CrossRefGoogle Scholar
  11. 11.
    Piastra M, Di Rocco C, Caresta E, Zorzi G, De Luca D, Caldarelli M, La Torre G, Conti G, Antonelli M, Eaton S, Pietrini D. Blood loss and short-term outcome of infants undergoing brain tumour removal. J Neurooncol. 2008;90(2):191–200.CrossRefGoogle Scholar
  12. 12.
    Kane PJ, Phipps KP, Harkness WF, Hayward RD. Intracranial neoplasms in the first year of life: results of a second cohort of patients from a single institution. Br J Neurosurg. 1999;13(3):294–8.CrossRefGoogle Scholar
  13. 13.
    Rutka JT, Kuo JS. Pediatric surgical neuro-oncology: current best care practices and strategies. J Neurooncol. 2004;69(1-3):139–50.CrossRefGoogle Scholar
  14. 14.
    Di Rocco C, Iannelli A, Ceddia A. Intracranial tumors of the first year of life. Childs Nerv Syst. 1991;7:150–3.CrossRefGoogle Scholar
  15. 15.
    Murto KTT, Splinter WM. Perioperative autologous blood donation in children. Transfus Sci. 1999;21(1):41–62.CrossRefGoogle Scholar
  16. 16.
    Otten ML, Riina HA, Gobin YP, Souweidane MM. Preoperative embolization in the treatment of choroid plexus papilloma in an infant. Case report. J Neurosurg. 2006;104(6 Suppl):419–21.Google Scholar
  17. 17.
    Stummer W, Pichlmeier U, Meinel T, Wiestler OD, Zanella F, Reulen HJ, ALA-Glioma Study Group. Fluorescence-guided surgery with 5-aminolevulinic acid for resection of malignant glioma: a randomised controlled multicentre phase III trial. Lancet Oncol. 2006;7(5):392–401.CrossRefGoogle Scholar
  18. 18.
    Dhall G. Medulloblastoma. J Child Neurol. 2009;24(11):1418–30.CrossRefGoogle Scholar
  19. 19.
    Duffner PK, Horowitz ME, Krischer JP, Burger PC, Cohen ME, Sanford RA, Friedman HS, Kun LE. The treatment of malignant brain tumors in infants and very young children: an update of the Pediatric oncology group experience. Neuro Oncol. 1999;1(2):152–61.CrossRefGoogle Scholar
  20. 20.
    Grundy RG, Wilne SH, Robinson KJ, Ironside JW, Cox T, Chong WK, Michalski A, Campbell RH, Bailey CC, Thorp N, Pizer B, Punt J, Walker DA, Ellison DW. Machin D; Children's cancer and leukaemia group (formerly UKCCSG) brain tumour committee. Primary postoperative chemotherapy without radiotherapy for treatment of brain tumours other than ependymoma in children under 3 years: results of the first UKCCSG/SIOP CNS 9204 trial. Eur J Cancer. 2010;46(1):120–33.CrossRefGoogle Scholar
  21. 21.
    Grill J, Sainte-Rose C, Jouvet A, Gentet JC, Lejars O, Frappaz D, Doz F, Rialland X, Pichon F, Bertozzi AI, Chastagner P, Couanet D, Habrand JL, Raquin MA, Le Deley MC, Kalifa C. Treatment of medulloblastoma with postoperative chemotherapy alone: an SFOP prospective trial. Lancet Oncol. 2005;6(8):573–80.CrossRefGoogle Scholar
  22. 22.
    Vasilatou-Kosmidis H. Cancer in neonates and infants. Med Pediatr Oncol. 2003;41(1):7–9.CrossRefGoogle Scholar
  23. 23.
    Bleyer WA. Clinical pharmacology of intrathecal methotrexate. II. An improved dosage regimen derived from age related pharmacokinetics. Cancer Treat Rep. 1977;61:1419–25.Google Scholar
  24. 24.
    Taylor MD, Northcott PA, Korshunov A, Remke M, Cho YJ, Clifford SC, Eberhart CG, Parsons DW, Rutkowski S, Gajjar A, Ellison DW, Lichter P, Gilbertson RJ, Pomeroy SL, Kool M, Pfister SM. Molecular subgroups of medulloblastoma: the current consensus. Acta Neuropathol. 2012;123(4):465–72.CrossRefGoogle Scholar
  25. 25.
    Mack SC, Witt H, Piro RM, Gu L, Zuyderduyn S, Stütz AM, Wang X, Gallo M, Garzia L, Zayne K, Zhang X, Ramaswamy V, Jäger N, Jones DT, Sill M, Pugh TJ, Ryzhova M, Wani KM, Shih DJ, Head R, Remke M, Bailey SD, Zichner T, Faria CC, Barszczyk M, Stark S, Seker-Cin H, Hutter S, Johann P, Bender S, Hovestadt V, Tzaridis T, Dubuc AM, Northcott PA, Peacock J, Bertrand KC, Agnihotri S, Cavalli FM, Clarke I, Nethery-Brokx K, Creasy CL, Verma SK, Koster J, Wu X, Yao Y, Milde T, Sin-Chan P, Zuccaro J, Lau L, Pereira S, Castelo-Branco P, Hirst M, Marra MA, Roberts SS, Fults D, Massimi L, Cho YJ, Van Meter T, Grajkowska W, Lach B, Kulozik AE, von Deimling A, Witt O, Scherer SW, Fan X, Muraszko KM, Kool M, Pomeroy SL, Gupta N, Phillips J, Huang A, Tabori U, Hawkins C, Malkin D, Kongkham PN, Weiss WA, Jabado N, Rutka JT, Bouffet E, Korbel JO, Lupien M, Aldape KD, Bader GD, Eils R, Lichter P, Dirks PB, Pfister SM, Korshunov A, Taylor MD. Epigenomic alterations define lethal CIMP-positive ependymomas of infancy. Nature. 2014;506(7489):445–50.CrossRefGoogle Scholar
  26. 26.
    Larouche V, Huang A, Bartels U, Bouffet E. Tumours of the central nervous system in the first year of life. Pediatr Blood Cancer. 2007;49(7):1074–82.CrossRefGoogle Scholar
  27. 27.
    Qaddoumi I, Sultan I, Gajjar A. Outcome and prognostic features in Pediatric Gliomas. Cancer. 2009;115(24):5761–70.CrossRefGoogle Scholar
  28. 28.
    Duffner PK, Krischer JP, Burger PC, Cohen ME, Backstrom JW, Horowitz ME, Sanford RA, Friedman HS, Kun LE. Treatment of infants with malignant gliomas: the paediatric oncology group experience. J Neurooncol. 1996;28(2-3):245–56.CrossRefGoogle Scholar
  29. 29.
    Rorke LB, Hart MN, McLendon RE. 2000. Supratentorial primitive neuroectodermal tumour (PNET). In: Kleihues P, Cavenee WK Pathology and genetics of tumours of the nervous system. Lyon: International Agency for Research on Cancer. 141-144.Google Scholar
  30. 30.
    Reddy TR. Atypical teratoid/rhabdoid tumours of the central nervous system. J Neurooncol. 2005;75:309–13.CrossRefGoogle Scholar
  31. 31.
    Lafay-Cousin L, Keene D, Carret AS, Fryer C, Brossard J, Crooks B, Eisenstat D, Johnston D, Larouche V, Silva M, Wilson B, Zelcer S, Bartels U, Bouffet E. Choroid plexus tumors in children less than 36 months: the Canadian Pediatric brain tumor consortium (CPBTC) experience. Childs Nerv Syst. 2011;27(2):259–64.CrossRefGoogle Scholar
  32. 32.
    Mallucci C, Lellouch-Tubiana A, Salazar C, Cinalli G, Renier D, Sainte-Rose C, Pierre-Kahn A, Zerah M. The management of desmoplastic neuroepithelial tumours in childhood. Childs Nerv Syst. 2000;16(1):8–14.CrossRefGoogle Scholar

Copyright information

© Springer-Verlag London Ltd., part of Springer Nature 2018

Authors and Affiliations

  • Chris Barton
    • 1
  • Jothy Kandasamy
    • 2
  • Benedetta Pettorini
    • 3
  • Conor L. Mallucci
    • 4
  • Barry Pizer
    • 1
  1. 1.Department of OncologyAlder Hey Children’s HospitalLiverpoolUK
  2. 2.Department of NeurosurgeryRoyal Hospital for Sick ChildrenEdinburghUK
  3. 3.Department of NeurosurgeryAlder Key Children’s HospitalMerseysideUK
  4. 4.Department of NeurosurgeryAlder Hey Children’s NHS Foundation TrustLiverpoolUK

Personalised recommendations