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Congenital Lung Malformations

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Abstract

The development of the foregut, including the division of the esophagus from the tracheobronchial tree and the patterning and differentiation of the pulmonary anlage remains incompletely understood. Nonetheless, the last decade has made remarkable progress toward developing a more sophisticated model of the dynamic interactions of endoderm and mesoderm that give rise to the tracheobronchial tree, lung, and esophagus. Congenital cystic lesions such as congenital pulmonary airway malformation (alternatively congenital pulmonary adenomatoid malformation) (CPAM), bronchopulmonary sequestration (BPS), bronchogenic cysts, foregut duplications, and congenital lobar emphysema (CLE) arise from discrete perturbations within this interaction.

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Authors and Affiliations

  1. Department of Surgery, Yale School of Medicine, New Haven, CT, USA

    Emily R. Christison-Lagay MD

  2. Department of General and Thoracic Surgery, Children’s National Hospital, Washington, DC, USA

    Peter C. Kim MD, PhD

Authors
  1. Emily R. Christison-Lagay MD
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  2. Peter C. Kim MD, PhD
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Correspondence to Emily R. Christison-Lagay MD .

Editor information

Editors and Affiliations

  1. Division of Child Health, Alder Hey Children’s NHS Foundation Trust, Liverpool, United Kingdom

    Paul D. Losty

  2. University of Pennsylvania , Philadelphia, Pennsylvania, USA

    Alan W. Flake

  3. Childrens Hospital, University of Helsinki, Helsinki, Finland

    Risto J. Rintala

  4. Royal Children’s Hospital, University of Melbourne, Parkville, Victoria, Australia

    John M. Hutson

  5. Department of Surgery, Meiji University of Integrative Medicine, Kyoto, Japan

    Naomi lwai

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Christison-Lagay, E.R., Kim, P.C. (2018). Congenital Lung Malformations. In: Losty, P., Flake, A., Rintala, R., Hutson, J., lwai, N. (eds) Rickham's Neonatal Surgery. Springer, London. https://doi.org/10.1007/978-1-4471-4721-3_22

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  • DOI: https://doi.org/10.1007/978-1-4471-4721-3_22

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