Abstract
Emergent and multidisciplinary research paradigms have fundamentally transformed biomedical science and the delivery of clinical care. This shift has been manifested in a number of ways, including the rapid growth and increasing availability of high-throughput bio-molecular instrumentation and analysis platforms, innovative clinical research programs intended to accelerate the exchange of knowledge between various stakeholders, efforts to deliver precision or personalized healthcare informed by the unique molecular phenotypes of patients, and a growing focus on patient-centered research that occurs at the point-of-care and beyond. A common theme spanning such transformative changes is the use of rigorous and systematic approaches to the collection, management, integration, analysis, and dissemination of large-scale and heterogeneous data sets. Unfortunately, the absence of well-established theoretical and practical frameworks intended to address such needs remains a major impediment to the realization of a translational and knowledge-driven healthcare system, in which the best possible scientific evidence is used to inform the care of every patient. In this vacuum, the development of integrative clinical or translational research paradigms is significantly limited by the propagation of both data and expertise silos. In this and subsequent chapters of this book, we will present a broad framework and specific examples of how the deep integration of biomedical informatics with both biomedical research and clinical care delivery is essential to overcoming such barriers and achieving the benefits of a knowledge-based approach to the delivery of high-performance, quality, safe, and individually tailored healthcare.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Similar content being viewed by others
References
Embi PJ, Payne PR. Clinical research informatics: challenges, opportunities and definition for an emerging domain. J Am Med Inform Assoc. 2009;16(3):316–27. PubMed PMID: 19261934. Epub 2009/03/06.
Embi PJ, Payne PR. The role of biomedical informatics in facilitating outcomes research: current practice and future directions. Circulation. 2009;120:2393–9.
Payne PR, Johnson SB, Starren JB, Tilson HH, Dowdy D. Breaking the translational barriers: the value of integrating biomedical informatics and translational research. J Investig Med. 2005;53(4):192–200. PubMed PMID: 15974245, Epub 2005/06/25.
Payne PR, Embi PJ, Sen CK. Translational informatics: enabling high throughput research paradigms. Physiol Genomics. 2009;39(3):131–40.
Auffray C, Chen Z, Hood L. Systems medicine: the future of medical genomics and healthcare. Genome Med. 2009;1(1):2.1–2.11.
Barabasi AL, Oltvai ZN. Network biology: understanding the cell’s functional organization. Nat Rev Genet. 2004;5:101–13.
Butcher EC, Berg EL, Kunkel EJ. Systems biology in drug discovery. Nat Biotechnol. 2004;22(10):1253–9.
Hood L, Perlmutter RM. The impact of systems approaches on biological problems in drug discovery. Nat Biotechnol. 2004;22(10):1215–7.
Lussier YL, Chen JL. The emergence of genome-based drug repositioning. Sci Transl Med. 2011;3(96):1–3.
Sadimin ET, Foran DJ. Pathology imaging informatics for clinical practice and investigative and translational research. N Am J Med Sci. 2012;5(2):103–9. PubMed PMID: 22855694. Pubmed Central PMCID: 3407842.
Weston AD, Hood L. Systems biology, proteomics, and the future of health care: toward predictive, preventative, and personalized medicine. J Proteome Res. 2004;3(2):179–96.
Ahn AC, Tewari M, Poon CS, Phillips RS. The limits of reductionism in medicine: could systems biology offer an alternative? PLoS Med. 2006;3(6):709–13.
Embi PJ, Payne PR. Evidence generating medicine: redefining the research-practice relationship to complete the evidence cycle. Med Care. 2013;51:S87–91.
Friedman CP, Wong AK, Blumenthal D. Achieving a nationwide learning health system. Sci Transl Med. 2010;2(57):57cm29.
Hood L, Friend SH. Predictive, personalized, preventive, participatory (P4) cancer medicine. Nat Rev Clin Oncol. 2010;8:184–7.
Schadt EE, Bjorkegren JL. Network-enabled wisdom in biology, medicine, and health care. Sci Transl Med. 2012;4(115).
Jacobs A. The pathologies of big data. Commun ACM. 2009;52(8):36–44.
Lynch C. Big data: how do your data grow? Nature. 2008;455(7209):28–9.
Damschroder LJ, Aron DC, Keith RE, Kirsh SR, Alexander JA, Lowery JC. Fostering implementation of health services research findings into practice: a consolidated framework for advancing implementation science. Implement Sci. 2009;4(1):50.
Additional Reading
Ahn AC, Tewari M, Poon CS, Phillips RS. The limits of reductionism in medicine: could systems biology offer an alternative? PLoS Med. 2006;3(6):709–13.
Ash JS, Anderson NR, Tarczy-Hornoch P. People and organizational issues in research systems implementation. J Am Med Inform Assoc. 2008. PubMed PMID: 18308986.
Auffray C, Chen Z, Hood L. Systems medicine: the future of medical genomics and healthcare. Genome Med. 2009;1(1):2.1–2.11.
Barabasi AL, Oltvai ZN. Network biology: understanding the cell’s functional organization. Nat Rev Genet. 2004;5:101–13.
Cantor MN. Translational informatics: an industry perspective. J Am Med Inform Assoc. 2012;19(2):153–5. PubMed PMID: 22237867. Pubmed Central PMCID: 3277629.
Embi PJ, Payne PR. Clinical research informatics: challenges, opportunities and definition for an emerging domain. J Am Med Inform Assoc. 2009;16(3):316–27. PubMed PMID: 19261934. Epub 2009/03/06.
Embi PJ, Payne PR. The role of biomedical informatics in facilitating outcomes research: current practice and future directions. Circulation. 2009;120:2393–9.
Hood L, Friend SH. Predictive, personalized, preventive, participatory (P4) cancer medicine. Nat Rev Clin Oncol. 2010;8:184–7.
Kohane IS, Churchill SE, Murphy SN. A translational engine at the national scale: informatics for integrating biology and the bedside. J Am Med Inform Assoc. 2012;19(2):181–5. PubMed PMID: 22081225, Pubmed Central PMCID: 3277623.
Lussier YL, Chen JL. The emergence of genome-based drug repositioning. Sci Transl Med. 2011;3(96):1–3.
Payne PR, Embi PJ, Sen CK. Translational informatics: enabling high throughput research paradigms. Physiol Genomics. 2009;39:131–40.
Payne PR, Johnson SB, Starren JB, Tilson HH, Dowdy D. Breaking the translational barriers: the value of integrating biomedical informatics and translational research. J Investig Med. 2005;53(4):192–200. PubMed PMID: 15974245. Epub 2005/06/25. eng.
Payne PR, Pressler TR, Sarkar IN, Lussier Y. People, organizational, and leadership factors impacting informatics support for clinical and translational research. BMC Med Inform Decis Mak. 2013;13:20. PubMed PMID: 23388243. Pubmed Central PMCID: 3577661.
Searl MM, Borgi L, Chemali Z. It is time to talk about people: a human-centered healthcare system. Health Res Policy Syst. 2010;8(35).
Sittig DF, Singh H. A new socio-technical model for studying health information technology in complex adaptive healthcare systems. Qual Saf Health Care. 2011;19 Suppl 3:i68–74.
Weston AD, Hood L. Systems biology, proteomics, and the future of health care: toward predictive, preventative, and personalized medicine. J Proteome Res. 2004;3(2):179–96.
Yip YL. Unlocking the potential of electronic health records for translational research. Findings from the section on bioinformatics and translational informatics. Yearb Med Informa. 2012;7(1):135–8. PubMed PMID: 22890355.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2015 Springer-Verlag London
About this chapter
Cite this chapter
Payne, P.R.O., Embi, P.J. (2015). An Introduction to Translational Informatics and the Future of Knowledge-Driven Healthcare. In: Payne, P., Embi, P. (eds) Translational Informatics. Health Informatics. Springer, London. https://doi.org/10.1007/978-1-4471-4646-9_1
Download citation
DOI: https://doi.org/10.1007/978-1-4471-4646-9_1
Published:
Publisher Name: Springer, London
Print ISBN: 978-1-4471-4645-2
Online ISBN: 978-1-4471-4646-9
eBook Packages: MedicineMedicine (R0)