Abstract
Prostate-specific antigen (PSA) may be raised as a result of prostate cancer, benign prostatic hyperplasia (BPH), or prostatic infection. The European randomized study of PSA screening confirmed that prostate cancer mortality could be reduced by the measurement of PSA. A raised PSA usually prompts a transrectal ultrasound (TRUS)-guided biopsy. If this is positive, other staging investigations are indicated, including magnetic resonance imaging (MRI) and a bone scan. With all of this information to hand, an informed decision has to be made about which treatment option is best for that individual.
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Bibliography
Schroder FH, Hugosson J, Roobol MJ, et al. Prostate-cancer mortality at 11 years of follow-up. N Engl J Med. 2012;366:981–90.
Catalona WJ, Smith DS, Ornstein DK. Prostate cancer detection in men with serum PSA concentrations of 2.6 to 4.0 ng/mL and benign prostate examination. Enhancement of specificity with free PSA measurements. JAMA. 1997;277:1452–5.
De Bono JS, Oudard S, Ozguroglu M, et al. Cabazitaxel or mitoxantrone with prednisone in patients with metastatic castration-resistant prostate cancer (mCRPC) previously treated with docetaxel: final results of a multinational phase III trial (TROPIC). J Clin Oncol. 2010;28(suppl):4508.
de Bono JS, Oudard S, Ozguroglu M, et al. Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial. Lancet. 2010;376(9747):1147–54.
de Bono JS, Logothetis CJ, Molina J. Abiraterone and increased survival in metastatic prostate cancer. N Engl J Med. 2011;364:1995–2005.
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© 2013 Springer-Verlag London
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Kirby, R.S. (2013). Raised Prostate-Specific Antigen. In: Gontero, P., Kirby, R., Carson III, C. (eds) Problem Based Urology. Springer, London. https://doi.org/10.1007/978-1-4471-4634-6_24
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DOI: https://doi.org/10.1007/978-1-4471-4634-6_24
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